November, 10th : Seminare of Dr Lucilla Crudele (University of Bari, Italy)

Dr Lucilla Crudele, MD, PhD student in “Metabolism, Aging and Social Medicine” at the University of Bari, Italy, will give a seminar on November-10th at 2 pm in the Bibliothèque of the U1113. The title of the seminar is: Visceral Adiposity and Cancer: prevention and prediction of Hepatocellular Carcinoma and Gender-Specific Cancer

October 7-9, 2022: “Fête de la Science” in Lingolsheim

On the occasion of the last edition of the Fête de la Science (October 7-9, 2022), our doctoral students (Mahassen El-Khoury, Jana Mourtada, Sevda Recberlik, Céline Sieffert, Chloé Thibaudeau, Ourania Vlami, Mathieu Vogt, Mingyi Wu) designed and animated the workshop “From the Molecule to the Patient: Development of Innovative Therapies to Fight Cancer” at the…Continue reading October 7-9, 2022: “Fête de la Science” in Lingolsheim

09/2022: 3 new publications

Giolito MV, La Rosa T, Farhat D, Bodoirat S, Guardia G, Domon-Dell C, Galante P, Freund JN and Plateroti M (2022) Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRa1, in intestinal lesions. Molecular Oncology, doi: 10.1002/1878-0261.13298. In press. Giolito MV and Plateroti M (2022) Thyroid hormone signaling in the intestinal stem…Continue reading 09/2022: 3 new publications

09/16/2022 (10:30 a.m.): Seminar by Eliette Touati (Institut Pasteur Paris)

Eliette Touati, Director of Research at the Institut Pasteur in Paris, will present her work on “Genotoxicity associated with Helicobacter pylori infection and gastric carcinogenesis: impact of the USF1 transcription factor“. The seminar will take place on September 16 at 10:30 a.m. in the library of Inserm unit U1113, 3 Avenue Molière, 67200 STRASBOURG. To…Continue reading 09/16/2022 (10:30 a.m.): Seminar by Eliette Touati (Institut Pasteur Paris)

05/11/2022: Victor GOURAIN seminar (10 a.m.)

Victor GOURAINfrom the CR2TI (Center for Research in Transplantation and Translational Immunology) in NantesTeam: Impact of acute inflammation on host pathogen interactions and lung homeostasiswill give a seminar on Wednesday May 11 at 10 a.m. at the UMR-S1113 library in Hautepierre:““Single cell sequencing assays to investigate immune response during lung infection“”

03/2022 : New publication (blood)

A collaborative study between the Hôpital Saint-Louis, the Team 1 of UMR-S1113 and the IGBMC has identified a new form of high-risk acute B-cell lymphocytic leukemia. This study identified a novel high-risk B-ALL subtype characterized by a monoallelic deletion in 13q12.2 leading to the monoallelic ectopic expression of the homeobox transcription factor CDX2, located 138…Continue reading 03/2022 : New publication (blood)

03/2022 : New publication (Jean-Baptiste DELHORME / Isabelle GROSS)

This translational study shows that the transcription factor CDX2, which plays an essential role in the identity of intestinal cells, decreases the sensitivity to chemotherapy of patients with colorectal cancer by promoting the expression of genes involved in the elimination of cytotoxic molecules. It therefore opens the way to the development of new, more effective…Continue reading 03/2022 : New publication (Jean-Baptiste DELHORME / Isabelle GROSS)

02/2022 : New publication (Emilie BERSUDER / Isabelle GROSS)

This study unravels the mechanisms of regulation of the atypical cadherin MUCDHL, namely by mesalazine which is used to treat chronic inflammatory diseases. The results obtained highlight the importance of the cellular and molecular context in the activity of mesalazine and suggest that its chemopreventive activity against colorectal cancer depends on the genetic alterations of…Continue reading 02/2022 : New publication (Emilie BERSUDER / Isabelle GROSS)