Alain JUNG

Senior Scientist CLCC CPS

ORCID – ResearcherID

(+33) 03 88 27 53 67

List of publications :

De Azevedo, J., Mourtada, J., Bour, C., Devignot, V., Schultz, P., Borel, C., Pencreach, E., Mellitzer, G., Gaiddon, C., & Jung, A. C. (2022). The EXTREME Regimen Associating Cetuximab and Cisplatin Favors Head and Neck Cancer Cell Death and Immunogenicity with the Induction of an Anti-Cancer Immune Response. Cells, 11(18), 2866. https://doi.org/10.3390/cells11182866
Spaety, M.-E., Gries, A., Badie, A., Venkatasamy, A., Romain, B., Orvain, C., Yanagihara, K., Okamoto, K., Jung, A. C., Mellitzer, G., Pfeffer, S., & Gaiddon, C. (2019). HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers, 11(11), 1747. https://doi.org/10.3390/cancers11111747
Coliat, P., Ramolu, L., Jégu, J., Gaiddon, C., Jung, A. C., & Pencreach, E. (2019). Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC. Cancers, 11(10). https://doi.org/10.3390/cancers11101607
Job, S., Reyniès, A. de, Heller, B., Weiss, A., Guérin, E., Macabre, C., Ledrappier, S., Bour, C., Wasylyk, C., Etienne-Selloum, N., Brino, L., Gaiddon, C., Wasylyk, B., & Jung, A. C. (2019). Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction. Cancers, 11(6). https://doi.org/10.3390/cancers11060795
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Borel, C., Regnier-Gavier, O., Carinato, H., Guihard, S., Antoni, D., Demarchi, M., Sirlin, F., Exinger, D., Petit-Jean, E., Thiery, A., Bronner, G., Schultz, P., Flesch, H., Frasie, V., Prébay, D., Petit, T., Jung, A. C., Burgy, M., & Coliat, P. (2018). Interest to consider re-challenging by cetuximab and platinum containing regimen in recurrent Head and Neck Cancer. Oncotarget, 9(101), 37581–37588. https://doi.org/10.18632/oncotarget.26506
Mirghani, H., Jung, A. C., & Fakhry, C. (2017). Primary, secondary and tertiary prevention of human papillomavirus-driven head and neck cancers. European Journal of Cancer (Oxford, England: 1990), 78, 105–115. https://doi.org/10.1016/j.ejca.2017.03.021
Bonnin, N., Armandy, E., Carras, J., Ferrandon, S., Battiston-Montagne, P., Aubry, M., Guihard, S., Meyronet, D., Foy, J.-P., Saintigny, P., Ledrappier, S., Jung, A. C., Rimokh, R., Rodriguez-Lafrasse, C., & Poncet, D. (2016). MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma. Oncotarget, 7(28), 44023–44038. https://doi.org/10.18632/oncotarget.9829
Jung, A. C., Ray, A.-M., Ramolu, L., Macabre, C., Simon, F., Noulet, F., Blandin, A.-F., Renner, G., Lehmann, M., Choulier, L., Kessler, H., Abecassis, J., Dontenwill, M., & Martin, S. (2015). Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget, 6(39), 41884–41901. https://doi.org/10.18632/oncotarget.6099
Hanns, E., Job, S., Coliat, P., Wasylyk, C., Ramolu, L., Pencreach, E., Suarez-Carmona, M., Herfs, M., Ledrappier, S., Macabre, C., Abecassis, J., Wasylyk, B., & Jung, A. C. (2015). Human Papillomavirus-related tumours of the oropharynx display a lower tumour hypoxia signature. Oral Oncology, 51(9), 848–856. https://doi.org/10.1016/j.oraloncology.2015.06.003
Chamard-Jovenin, C., Jung, A. C., Chesnel, A., Abecassis, J., Flament, S., Ledrappier, S., Macabre, C., Boukhobza, T., & Dumond, H. (2015). From ERα66 to ERα36: a generic method for validating a prognosis marker of breast tumor progression. BMC Systems Biology, 9, 28. https://doi.org/10.1186/s12918-015-0178-7
Robertson, E. D., Wasylyk, C., Ye, T., Jung, A. C., & Wasylyk, B. (2014). The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PloS One, 9(11), e113050. https://doi.org/10.1371/journal.pone.0113050
Wasylyk, B., Abecassis, J., & Jung, A. C. (2013). Identification of clinically relevant HPV-related HNSCC: in p16 should we trust? Oral Oncology, 49(10), e33-37. https://doi.org/10.1016/j.oraloncology.2013.07.014
Ennen, M., Klotz, R., Touche, N., Pinel, S., Barbieux, C., Besancenot, V., Brunner, E., Thiebaut, D., Jung, A. C., Ledrappier, S., Domenjoud, L., Abecassis, J., Plénat, F., Grandemange, S., & Becuwe, P. (2013). DDB2: a novel regulator of NF-κB and breast tumor invasion. Cancer Research, 73(16), 5040–5052. https://doi.org/10.1158/0008-5472.CAN-12-3655
Jung, A. C., Job, S., Ledrappier, S., Macabre, C., Abecassis, J., de Reyniès, A., & Wasylyk, B. (2013). A poor prognosis subtype of HNSCC is consistently observed across methylome, transcriptome, and miRNome analysis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 19(15), 4174–4184. https://doi.org/10.1158/1078-0432.CCR-12-3690
Jung, A. C. (2013). Can liberating p53 from E6 free patients from HPV-related head and neck tumors? Cell Cycle (Georgetown, Tex.), 12(6), 868. https://doi.org/10.4161/cc.24101
Jung, A. C., Guihard, S., Krugell, S., Ledrappier, S., Brochot, A., Dalstein, V., Job, S., de Reynies, A., Noël, G., Wasylyk, B., Clavel, C., & Abecassis, J. (2013). CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis. International Journal of Cancer, 132(2), E26-36. https://doi.org/10.1002/ijc.27776
Guihard, S., Ramolu, L., Macabre, C., Wasylyk, B., Noël, G., Abecassis, J., & Jung, A. C. (2012). The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation. International Journal of Oncology, 41(4), 1531–1540. https://doi.org/10.3892/ijo.2012.1584
Guihard, S., Jung, A. C., & Noël, G. (2012). [High-risk human papilloma virus associated oropharynx squamous cell carcinomas: clinical, biological implications and therapeutical perspectives]. Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique, 16(1), 34–43. https://doi.org/10.1016/j.canrad.2011.11.001
Chanut-Delalande, H., Jung, A. C., Baer, M. M., Lin, L., Payre, F., & Affolter, M. (2010). The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development. PloS One, 5(4), e10245. https://doi.org/10.1371/journal.pone.0010245
Jung, A. C., Briolat, J., Millon, R., Reyniès, A. de, Rickman, D., Thomas, E., Abecassis, J., Clavel, C., & Wasylyk, B. (2010). Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. International Journal of Cancer, 126(8), 1882–1894. https://doi.org/10.1002/ijc.24911
Altmeyer, A., Jung, A. C., Ignat, M., Benzina, S., Denis, J.-M., Gueulette, J., Noël, G., Mutter, D., & Bischoff, P. (2010). Pharmacological enhancement of autophagy induced in a hepatocellular carcinoma cell line by high-LET radiation. Anticancer Research, 30(2), 303–310.
Chanut-Delalande, H., Jung, A. C., Lin, L., Baer, M. M., Bilstein, A., Cabernard, C., Leptin, M., & Affolter, M. (2007). A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Genetics, 176(4), 2177–2187. https://doi.org/10.1534/genetics.107.073890
Jung, A. C., Ribeiro, C., Michaut, L., Certa, U., & Affolter, M. (2006). Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. Current Biology: CB, 16(12), 1224–1231. https://doi.org/10.1016/j.cub.2006.04.048
Jung, A. C., Denholm, B., Skaer, H., & Affolter, M. (2005). Renal tubule development in Drosophila: a closer look at the cellular level. Journal of the American Society of Nephrology: JASN, 16(2), 322–328. https://doi.org/10.1681/ASN.2004090729
Jung, A. C., Criqui, M. C., Rutschmann, S., Hoffmann, J. A., & Ferrandon, D. (2001). Microfluorometer assay to measure the expression of beta-galactosidase and green fluorescent protein reporter genes in single Drosophila flies. BioTechniques, 30(3), 594–598, 600–601. https://doi.org/10.2144/01303rr04
Rutschmann, S., Jung, A. C., Zhou, R., Silverman, N., Hoffmann, J. A., & Ferrandon, D. (2000). Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Nature Immunology, 1(4), 342–347. https://doi.org/10.1038/79801
Rutschmann, S., Jung, A. C., Hetru, C., Reichhart, J. M., Hoffmann, J. A., & Ferrandon, D. (2000). The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity, 12(5), 569–580.
Ferrandon, D., Jung, A. C., Criqui, M., Lemaitre, B., Uttenweiler-Joseph, S., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1998). A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. The EMBO Journal, 17(5), 1217–1227. https://doi.org/10.1093/emboj/17.5.1217