Dominique GUENOT

Research Director 2 CNRS

ORCID – Profil LinkedinResearchGateResearcherIDCV

(+33) 03 88 27 53 62

 

 

 

List of publications :

 

Pensec, C., Gillaizeau, F., Guenot, D., Bessard, A., Carton, T., Leuillet, S., Campone, M., Neunlist, M., Blottière, H. M., & Le Vacon, F. (2020). Impact of pemetrexed chemotherapy on the gut microbiota and intestinal inflammation of patient-lung-derived tumor xenograft (PDX) mouse models. Scientific Reports, 10(1), 9094. https://doi.org/10.1038/s41598-020-65792-6
Blandin, A.-F., Durand, A., Litzler, M., Tripp, A., Guérin, É., Ruhland, E., Obrecht, A., Keime, C., Fuchs, Q., Reita, D., Lhermitte, B., Coca, A., Jones, C., Rebel, I. L., Villa, P., Namer, I. J., Dontenwill, M., Guenot, D., & Entz-Werle, N. (2019). Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity. Cancers, 11(12). https://doi.org/10.3390/cancers11121875
Reita, D., Bour, C., Benbrika, R., Groh, A., Pencreach, E., Guérin, E., & Guenot, D. (2019). Synergistic Anti-Tumor Effect of mTOR Inhibitors with Irinotecan on Colon Cancer Cells. Cancers, 11(10). https://doi.org/10.3390/cancers11101581
Fechter, P., Cruz Da Silva, E., Mercier, M.-C., Noulet, F., Etienne-Seloum, N., Guenot, D., Lehmann, M., Vauchelles, R., Martin, S., Lelong-Rebel, I., Ray, A.-M., Seguin, C., Dontenwill, M., & Choulier, L. (2019). RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma. Molecular Therapy. Nucleic Acids, 17, 63–77. https://doi.org/10.1016/j.omtn.2019.05.006
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Mammadova-Bach, E., Rupp, T., Spenlé, C., Jivkov, I., Shankaranarayanan, P., Klein, A., Pisarsky, L., Méchine-Neuville, A., Cremel, G., Kedinger, M., De Wever, O., Ambartsumian, N., Robine, S., Pencreach, E., Guenot, D., Simon-Assmann, P., Goetz, J. G., Orend, G., & Lefebvre, O. (2018). Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biology of the Cell, 110(8), 178–195. https://doi.org/10.1111/boc.201800007
Emprou, C., Le Van Quyen, P., Jégu, J., Prim, N., Weingertner, N., Guérin, E., Pencreach, E., Legrain, M., Voegeli, A.-C., Leduc, C., Mennecier, B., Falcoz, P.-E., Olland, A., Santelmo, N., Quoix, E., Massard, G., Guenot, D., Chenard, M.-P., & Beau-Faller, M. (2018). SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients. Cancer Medicine, 7(7), 3278–3291. https://doi.org/10.1002/cam4.1545
Romain, B., Rohmer, O., Schimchowitsch, S., Hübner, M., Delhorme, J.-B., Brigand, C., Rohr, S., & Guenot, D. (2018). Influence of preoperative life satisfaction on recovery and outcomes after colorectal cancer surgery - a prospective pilot study. Health and Quality of Life Outcomes, 16(1), 16. https://doi.org/10.1186/s12955-017-0824-4
Marisa, L., Svrcek, M., Collura, A., Becht, E., Cervera, P., Wanherdrick, K., Buhard, O., Goloudina, A., Jonchère, V., Selves, J., Milano, G., Guenot, D., Cohen, R., Colas, C., Laurent-Puig, P., Olschwang, S., Lefèvre, J. H., Parc, Y., Boige, V., … Duval, A. (2018). The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors. Journal of the National Cancer Institute, 110(1), 68–77. https://doi.org/10.1093/jnci/djx136
Nguyen, A., Moussallieh, F. M., Mackay, A., Cicek, A. E., Coca, A., Chenard, M. P., Weingertner, N., Lhermitte, B., Letouzé, E., Guérin, E., Pencreach, E., Jannier, S., Guenot, D., Namer, I. J., Jones, C., & Entz-Werlé, N. (2017). Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition. Oncotarget, 8(42), 71597–71617. https://doi.org/10.18632/oncotarget.16500
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., Poidevin, L., Bour, C., Freund, J.-N., Duluc, I., Guenot, D., & Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366. https://doi.org/10.18632/oncotarget.16323
Renaud, S., Schaeffer, M., Falcoz, P.-E., Seitlinger, J., Romain, B., Voegeli, A.-C., Legrain, M., Reeb, J., Santelmo, N., Rohr, S., Brigand, C., Olland, A., Guenot, D., & Massard, G. (2017). Perioperative bevacizumab improves survival following lung metastasectomy for colorectal cancer in patients harbouring v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue exon 2 codon 12 mutations†. European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery, 51(2), 255–262. https://doi.org/10.1093/ejcts/ezw304
Farah, I., Nguyen, T. N. Q., Groh, A., Guenot, D., Jeannesson, P., & Gobinet, C. (2016). Development of a memetic clustering algorithm for optimal spectral histology: application to FTIR images of normal human colon. The Analyst, 141(11), 3296–3304. https://doi.org/10.1039/c5an02227d
Nguyen, T. N. Q., Jeannesson, P., Groh, A., Piot, O., Guenot, D., & Gobinet, C. (2016). Fully unsupervised inter-individual IR spectral histology of paraffinized tissue sections of normal colon. Journal of Biophotonics, 9(5), 521–532. https://doi.org/10.1002/jbio.201500285
Renaud, S., Falcoz, P.-E., Romain, B., Olland, A., Santelmo, N., Brigand, C., Rohr, S., Guenot, D., & Massard, G. (2015). Reply: Comment on “KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colo-rectal cancer.” British Journal of Cancer, 113(11), 1637–1638. https://doi.org/10.1038/bjc.2015.330
Renaud, S., Falcoz, P.-E., Schaëffer, M., Guenot, D., Romain, B., Olland, A., Reeb, J., Santelmo, N., Chenard, M.-P., Legrain, M., Voegeli, A.-C., Beau-Faller, M., & Massard, G. (2015). Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases. British Journal of Cancer, 113(8), 1206–1215. https://doi.org/10.1038/bjc.2015.327
Weingertner, N., Meyer, N., Voegeli, A.-C., Guenot, D., Renaud, S., Massard, G., Falcoz, P.-E., Olland, A., Mennecier, B., Gaub, M.-P., Lindner, V., Ghnassia, J.-P., Quoix, E., Chenard, M.-P., & Beau-Faller, M. (2015). Correlation between MET protein expression and MET gene copy number in a Caucasian cohort of non-small cell lung cancers according to the new IASLC/ATS/ERS classification. Pathology, 47(4), 320–328. https://doi.org/10.1097/PAT.0000000000000269
Nguyen, T. N. Q., Jeannesson, P., Groh, A., Guenot, D., & Gobinet, C. (2015). Development of a hierarchical double application of crisp cluster validity indices: a proof-of-concept study for automated FTIR spectral histology. The Analyst, 140(7), 2439–2448. https://doi.org/10.1039/c4an01937g
Renaud, S., Romain, B., Falcoz, P.-E., Olland, A., Santelmo, N., Brigand, C., Rohr, S., Guenot, D., & Massard, G. (2015). KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. British Journal of Cancer, 112(4), 720–728. https://doi.org/10.1038/bjc.2014.499
Manceau, G., Marisa, L., Boige, V., Duval, A., Gaub, M.-P., Milano, G., Selves, J., Olschwang, S., Jooste, V., le Legrain, M., Lecorre, D., Guenot, D., Etienne-Grimaldi, M.-C., Kirzin, S., Martin, L., Lepage, C., Bouvier, A.-M., & Laurent-Puig, P. (2015). PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer. Cancer Medicine. https://doi.org/10.1002/cam4.370
Spenlé, C., Gasser, I., Saupe, F., Janssen, K.-P., Arnold, C., Klein, A., van der Heyden, M., Mutterer, J., Neuville-Méchine, A., Chenard, M.-P., Guenot, D., Esposito, I., Slotta-Huspenina, J., Ambartsumian, N., Simon-Assmann, P., & Orend, G. (2015). Spatial organization of the tenascin-C microenvironment in experimental and human cancer. Cell Adhesion & Migration, 9(1–2), 4–13. https://doi.org/10.1080/19336918.2015.1005452
Lasthaus, C., Litzler, M., Marcellin, L., Chenard, M.-P., Marec-Bérard, P., Tabone, M.-D., Pacquement, H., Brugieres, L., Guenot, D., & Entz-Werlé, N. (2015). Molecular Reclassification in Pediatric Osteosarcomas at Surgical Resection is a Potential Helpful Prognostic Marker. Journal of Molecular Biomarkers & Diagnosis, 06(02). https://doi.org/10.4172/2155-9929.1000229
Nguyen, A., Legrain, M., Noel, G., Coca, A., Meyer Ea, N., Schott, R., Lasthaus, C., Chenard, M. P., Gaub, M. P., Lessinger, J. M., Guenot, D., & Entz-Werle, N. (2015). An Innovative Fluorescent Semi-quantitative Methylation-specific PCR Method for the Determination of MGMT Promoter Methylation is Reflecting Intra-tumor Heterogeneity. Current Cancer Drug Targets, 15(7), 624–640.
Prim, N., Legrain, M., Guerin, E., Mennecier, B., Weingertner, N., Voegeli, A.-C., Guenot, D., Maugard, C. M., Quoix, A.-E., & Beau-Faller, M. (2014). Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients. European Respiratory Review: An Official Journal of the European Respiratory Society, 23(133), 390–392. https://doi.org/10.1183/09059180.00009313
Romain, B., Meyer, N., Brigand, C., Chenard, M.-P., Schneider, A., & Guenot, D. (2014). Molecular markers for recurrence and sensitivity to preoperative chemoradiotherapy in locally advanced rectal tumours. Digestive Surgery, 31(4–5), 347–353. https://doi.org/10.1159/000368122
Romain, B., Hachet-Haas, M., Rohr, S., Brigand, C., Galzi, J.-L., Gaub, M.-P., Pencreach, E., & Guenot, D. (2014). Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. Molecular Cancer, 13, 58. https://doi.org/10.1186/1476-4598-13-58
Schmitt, C., Voegelin, M., Marin, A., Schmitt, M., Schegg, F., Hénon, P., Guenot, D., & Tarnus, C. (2013). Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorganic & Medicinal Chemistry, 21(7), 2135–2144. https://doi.org/10.1016/j.bmc.2012.12.038
Marisa, L., de Reyniès, A., Duval, A., Selves, J., Gaub, M. P., Vescovo, L., Etienne-Grimaldi, M.-C., Schiappa, R., Guenot, D., Ayadi, M., Kirzin, S., Chazal, M., Fléjou, J.-F., Benchimol, D., Berger, A., Lagarde, A., Pencreach, E., Piard, F., Elias, D., … Boige, V. (2013). Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Medicine, 10(5), e1001453. https://doi.org/10.1371/journal.pmed.1001453
Nguyen, A., Lasthaus, C., Guerin, E., Marcellin, L., Pencreach, E., Gaub, M.-P., Guenot, D., & Entz-Werle, N. (2013). Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse. Cancers, 5(2), 662–675. https://doi.org/10.3390/cancers5020662
Cosset, E. C., Godet, J., Entz-Werlé, N., Guérin, E., Guenot, D., Froelich, S., Bonnet, D., Pinel, S., Plenat, F., Chastagner, P., Dontenwill, M., & Martin, S. (2012). Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma. International Journal of Cancer. Journal International Du Cancer, 131(3), 601–611. https://doi.org/10.1002/ijc.26415
Janouskova, H., Maglott, A., Leger, D. Y., Bossert, C., Noulet, F., Guerin, E., Guenot, D., Pinel, S., Chastagner, P., Plenat, F., Entz-Werle, N., Lehmann-Che, J., Godet, J., Martin, S., Teisinger, J., & Dontenwill, M. (2012). Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma. Cancer Research, 72(14), 3463–3470. https://doi.org/10.1158/0008-5472.CAN-11-4199
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Guérin, E., Raffelsberger, W., Pencreach, E., Maier, A., Neuville, A., Schneider, A., Bachellier, P., Rohr, S., Petitprez, A., Poch, O., Moras, D., Oudet, P., Larsen, A. K., Gaub, M.-P., & Guenot, D. (2012). In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1α target genes and decreases tumor angiogenesis. Molecular Medicine (Cambridge, Mass.), 18, 83–94. https://doi.org/10.2119/molmed.2011.00120
Neuville, A., Nicolet, C., Meyer, N., Schneider, A., Legrain, M., Brigand, C., Duclos, B., Bachellier, P., Oudet, P., Bellocq, J.-P., Kedinger, M., Gaub, M.-P., & Guenot, D. (2011). Histologic characteristics of non-microsatellite-instable colon adenomas correlate with distinct molecular patterns. Human Pathology, 42(2), 244–253. https://doi.org/10.1016/j.humpath.2010.07.003
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., Simo-Noumbissie, P., Guérin, E., Gaub, M.-P., Freund, J.-N., Boehm, N., Constantinesco, A., Lutz, P., Guenot, D., & Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Romain, B., Neuville, A., Meyer, N., Brigand, C., Rohr, S., Schneider, A., Gaub, M.-P., & Guenot, D. (2010). Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment. BMC Cancer, 10, 561. https://doi.org/10.1186/1471-2407-10-561
Nicolet, C., Guérin, E., Neuville, A., Kerckaert, J.-P., Wicker, N., Bergmann, E., Brigand, C., Kedinger, M., Gaub, M.-P., & Guenot, D. (2009). Evidence for various 20q status using allelotyping, CGH arrays, and quantitative PCR in distal CIN colon cancers. Cancer Letters, 282(2), 195–204. https://doi.org/10.1016/j.canlet.2009.03.012
Pencreach, E., Guérin, E., Nicolet, C., Lelong-Rebel, I., Voegeli, A.-C., Oudet, P., Larsen, A. K., Gaub, M.-P., & Guenot, D. (2009). Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 15(4), 1297–1307. https://doi.org/10.1158/1078-0432.CCR-08-0889
Wolthuis, R., Travo, A., Nicolet, C., Neuville, A., Gaub, M.-P., Guenot, D., Ly, E., Manfait, M., Jeannesson, P., & Piot, O. (2008). IR spectral imaging for histopathological characterization of xenografted human colon carcinomas. Analytical Chemistry, 80(22), 8461–8469. https://doi.org/10.1021/ac801191x
Weber, J.-C., Meyer, N., Pencreach, E., Schneider, A., Guérin, E., Neuville, A., Stemmer, C., Brigand, C., Bachellier, P., Rohr, S., Kedinger, M., Meyer, C., Guenot, D., Oudet, P., Jaeck, D., & Gaub, M.-P. (2007). Allelotyping analyses of synchronous primary and metastasis CIN colon cancers identified different subtypes. International Journal of Cancer. Journal International Du Cancer, 120(3), 524–532. https://doi.org/10.1002/ijc.22343
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., Brabletz, T., Kedinger, M., Freund, J.-N., & Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744. https://doi.org/10.2353/ajpath.2007.060696
Guenot, D., Guérin, E., Aguillon-Romain, S., Pencreach, E., Schneider, A., Neuville, A., Chenard, M.-P., Duluc, I., Du Manoir, S., Brigand, C., Oudet, P., Kedinger, M., & Gaub, M.-P. (2006). Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability. The Journal of Pathology, 208(5), 643–652. https://doi.org/10.1002/path.1936
Domon-Dell, C., Schneider, A., Moucadel, V., Guerin, E., Guenot, D., Aguillon, S., Duluc, I., Martin, E., Iovanna, J., Launay, J.-F., Duclos, B., Chenard, M.-P., Meyer, C., Oudet, P., Kedinger, M., Gaub, M.-P., & Freund, J.-N. (2003). Cdx1 homeobox gene during human colon cancer progression. Oncogene, 22(39), 7913–7921. https://doi.org/10.1038/sj.onc.1206756