Jean-Noël FREUND

El Omar, R., Abdellaoui, N., Coulibaly, S., Fontenille, L., Lanza, F., Gachet, C., Freund, J.-N., Negroni, M., Kissa, K., & Tavian, M. (2024). Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo. https://u1113-inserm.fr/3-publications-recentes-realisees-par-le-groupe-onco-hematologie-dans-le-cadre-de-lumr-s1113-irfac-de-linserm-universite-de-strasbourg/

Scarfò, R., Randolph, L. N., Abou Alezz, M., El Khoury, M., Gersch, A., Li, Z.-Y., Luff, S. A., Tavosanis, A., Ferrari Ramondo, G., Valsoni, S., Cascione, S., Didelon, E., Passerini, L., Amodio, G., Brandas, C., Villa, A., Gregori, S., Merelli, I., Freund, J.-N., … Ditadi, A. (2024). CD32 captures committed haemogenic endothelial cells during human embryonic development. Nature Cell Biology. https://doi.org/10.1038/s41556-024-01403-0

Gotru, S. K., Mammadova-Bach, E., Sogkas, G., Schuhmann, M. K., Schmitt, K., Kraft, P., Herterich, S., Mamtimin, M., Pinarci, A., Beck, S., Stritt, S., Chao, H., Ren, P., Freund, J.-N., Klemann, C., Ringshausen, F. C., Heemskerk, J. W. M., Dietrich, A., Nieswandt, B., … Braun, A. (2023). MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/ATVBAHA.122.318115

Säisä-Borreill, S., Davidson, G., Kleiber, T., Thevenot, A., Martin, E., Mondot, S., Blottière, H., Helleux, A., Mengus, G., Plateroti, M., Duluc, I., Davidson, I., & Freund, J.-N. (2023). General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions. Cell Death and Differentiation. https://doi.org/10.1038/s41418-022-01109-6

Collard, M. K., Tourneur-Marsille, J., Uzzan, M., Albuquerque, M., Roy, M., Dumay, A., Freund, J.-N., Hugot, J.-P., Guedj, N., Treton, X., Panis, Y., & Ogier-Denis, E. (2022). The appendix orchestrates T-cell mediated immunosurveillance in colitis-associated cancer. Cellular and Molecular Gastroenterology and Hepatology, S2352-345X(22)00230-2. https://doi.org/10.1016/j.jcmgh.2022.10.016

Passet, M., Kim, R., Gachet, S., Sigaux, F., Chaumeil, J., Galland, A., Sexton, T., Quentin, S., Hernandez, L., Larcher, L., Bergugnat, H., Ye, T., Karasu, N., Caye-Eude, A., Heizmann, B., Duluc, I., Chevallier, P., Rousselot, P., Huguet, F., … Clappier, E. (2022). Concurrent CDX2 cis-deregulation and UBTF-ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL. Blood, blood.2021014723. https://doi.org/10.1182/blood.2021014723

Bersuder, E., Terciolo, C., Lechevrel, M., Martin, E., Quesnelle, C., Freund, J.-N., Reimund, J.-M., & Gross, I. (2022). Mesalazine initiates an anti-oncogenic β-catenin / MUCDHL negative feed-back loop in colon cancer cells by cell-specific mechanisms. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 146, 112543. https://doi.org/10.1016/j.biopha.2021.112543

Delhorme, J.-B., Bersuder, E., Terciolo, C., Vlami, O., Chenard, M.-P., Martin, E., Rohr, S., Brigand, C., Duluc, I., Freund, J.-N., & Gross, I. (2022). CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 147, 112630. https://doi.org/10.1016/j.biopha.2022.112630

Priya, S., Kaur, E., Kulshrestha, S., Pandit, A., Gross, I., Kumar, N., Agarwal, H., Khan, A., Shyam, R., Bhagat, P., Prabhu, J. S., Nagarajan, P., Deo, S. V. S., Bajaj, A., Freund, J.-N., Mukhopadhyay, A., & Sengupta, S. (2021). CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors. Journal of Cell Science, 134(15), jcs258601. https://doi.org/10.1242/jcs.258601

Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Nevé, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., de la Fouchardiere, C., & Plateroti, M. (2021). Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy. Cancer Research, 81(10), 2730–2744. https://doi.org/10.1158/0008-5472.CAN-20-2450

Galland, A., Gourain, V., Habbas, K., Güler, Y., Martin, E., Ebel, C., Tavian, M., Vallat, L., Chenard, M.-P., Mauvieux, L., Freund, J.-N., Duluc, I., & Domon-Dell, C. (2021). CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition. Molecular Oncology. https://doi.org/10.1002/1878-0261.12982

Schleiss, C., Carapito, R., Fornecker, L.-M., Muller, L., Paul, N., Tahar, O., Pichot, A., Tavian, M., Nicolae, A., Miguet, L., Mauvieux, L., Herbrecht, R., Cianferani, S., Freund, J.-N., Carapito, C., Maumy-Bertrand, M., Bahram, S., Bertrand, F., & Vallat, L. (2021). Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia. Leukemia, 35(5), 1463–1474. https://doi.org/10.1038/s41375-021-01221-5

Julien, E., Biasch, K., El Omar, R., Freund, J.-N., Gachet, C., Lanza, F., & Tavian, M. (2021). Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells. Stem Cells (Dayton, Ohio), 39(5), 636–649. https://doi.org/10.1002/stem.3339

Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Le Nevé, C., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway. Development (Cambridge, England), 148(8), dev194357. https://doi.org/10.1242/dev.194357

El Omar, R., Julien, E., Biasch, K., Guffroy, B., Lioure, B., Vallat, L., Gross, I., Domon-Dell, C., Lanza, F., Gachet, C., Negroni, M., Freund, J.-N., & Tavian, M. (2021). CDX2 regulates ACE expression in blood development and leukemia cells. Blood Advances, 5(7), 2012–2016. https://doi.org/10.1182/bloodadvances.2020003563

Beck, M., Baranger, M., Moufok-Sadoun, A., Bersuder, E., Hinkel, I., Mellitzer, G., Martin, E., Marisa, L., Duluc, I., de Reynies, A., Gaiddon, C., Freund, J.-N., & Gross, I. (2021). The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Oncogene, 40(3), 522–535. https://doi.org/10.1038/s41388-020-01546-y

Gourain, V., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2021). A Core Response to the CDX2 Homeoprotein During Development and in Pathologies. Frontiers in Genetics, 12, 744165. https://doi.org/10.3389/fgene.2021.744165

Tusamda Wakhloo, N., Anders, S., Badique, F., Eichhorn, M., Brigaud, I., Petithory, T., Vassaux, M., Milan, J.-L., Freund, J.-N., Rühe, J., Davidson, P. M., Pieuchot, L., & Anselme, K. (2020). Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography. Biomaterials, 234, 119746. https://doi.org/10.1016/j.biomaterials.2019.119746

Licona, C., Delhorme, J.-B., Riegel, G., Vidimar, V., Cerón-Camacho, R., Boff, B., Venkatasamy, A., Tomasetto, C., da Silva Figueiredo Celestino Gomes, P., Rognan, D., Freund, J.-N., Le Lagadec, R., Pfeffer, M., Gross, I., Mellitzer, G., & Gaiddon, C. (2020). Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms. Inorganic Chemistry Frontiers, 7(3), 678–688. https://doi.org/10.1039/C9QI01148J

Grall, E., Gourain, V., Naïr, A., Martin, E., Birling, M.-C., Freund, J.-N., & Duluc, I. (2019). Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs. Cell Death & Disease, 10(11), 812. https://doi.org/10.1038/s41419-019-2040-0

Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029

Rabineau, M., Flick, F., Ehlinger, C., Mathieu, E., Duluc, I., Jung, M., Senger, B., Kocgozlu, L., Schaaf, P., Lavalle, P., Freund, J.-N., Haikel, Y., & Vautier, D. (2018). Chromatin de-condensation by switching substrate elasticity. Scientific Reports, 8(1), 12655. https://doi.org/10.1038/s41598-018-31023-2

Balbinot, C., Armant, O., Elarouci, N., Marisa, L., Martin, E., De Clara, E., Onea, A., Deschamps, J., Beck, F., Freund, J.-N., & Duluc, I. (2018). The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. The Journal of Experimental Medicine, 215(3), 911–926. https://doi.org/10.1084/jem.20170934

Balbinot, C., Vanier, M., Armant, O., Nair, A., Penichon, J., Soret, C., Martin, E., Saandi, T., Reimund, J.-M., Deschamps, J., Beck, F., Domon-Dell, C., Gross, I., Duluc, I., & Freund, J.-N. (2017). Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death and Differentiation, 24(12), 2173–2186. https://doi.org/10.1038/cdd.2017.140

Dillenseger, J.-P., Goetz, C., Sayeh, A., Healy, C., Duluc, I., Freund, J.-N., Constantinesco, A., Aubertin-Kirch, G., & Choquet, P. (2017). Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. Journal of Medical Imaging (Bellingham, Wash.), 4(3), 035503. https://doi.org/10.1117/1.JMI.4.3.035503

Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., Poidevin, L., Bour, C., Freund, J.-N., Duluc, I., Guenot, D., & Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366. https://doi.org/10.18632/oncotarget.16323

Platet, N., Hinkel, I., Richert, L., Murdamoothoo, D., Moufok-Sadoun, A., Vanier, M., Lavalle, P., Gaiddon, C., Vautier, D., Freund, J.-N., & Gross, I. (2017). The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Letters, 386, 57–64. https://doi.org/10.1016/j.canlet.2016.10.040

Reimund, J.-M., & Freund, J.-N. (2017). Inflammatory Bowel Disease-associated Cancer. In M. Schwab (Ed.), Encyclopedia of Cancer (pp. 2256–2263). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_3046

Gillard, L., Billiauws, L., Stan-Iuga, B., Ribeiro-Parenti, L., Jarry, A.-C., Cavin, J.-B., Cluzeaud, F., Mayeur, C., Thomas, M., Freund, J.-N., Lacorte, J.-M., Le Gall, M., Bado, A., Joly, F., & Le Beyec, J. (2016). Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome. Scientific Reports, 6, 28345. https://doi.org/10.1038/srep28345

Soret, C., Martin, E., Duluc, I., Dantzer, F., Vanier, M., Gross, I., Freund, J.-N., & Domon-Dell, C. (2016). Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Letters, 374(2), 208–215. https://doi.org/10.1016/j.canlet.2016.02.026

Freund, J.-N., Duluc, I., Reimund, J.-M., Gross, I., & Domon-Dell, C. (2015). Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World Journal of Gastroenterology, 21(5), 1436–1443. https://doi.org/10.3748/wjg.v21.i5.1436

Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.-N., Duluc, I., Gachet, C., Lanza, F., & Léon, C. (2015). Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage. Journal of Thrombosis and Haemostasis: JTH, 13(1), 115–125. https://doi.org/10.1111/jth.12784

Rabineau, M., Flick, F., Mathieu, E., Tu, A., Senger, B., Voegel, J.-C., Lavalle, P., Schaaf, P., Freund, J.-N., Haikel, Y., & Vautier, D. (2015). Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. Biomaterials, 37, 144–155. https://doi.org/10.1016/j.biomaterials.2014.10.023

Modica, S., Cariello, M., Morgano, A., Gross, I., Vegliante, M. C., Murzilli, S., Salvatore, L., Freund, J.-N., Sabbà, C., & Moschetta, A. (2014). Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). The Journal of Biological Chemistry, 289(41), 28421–28432. https://doi.org/10.1074/jbc.M114.571513

Martianov, I., Cler, E., Duluc, I., Vicaire, S., Philipps, M., Freund, J.-N., & Davidson, I. (2014). TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PloS One, 9(2), e87365. https://doi.org/10.1371/journal.pone.0087365

Tréton, X., Pedruzzi, E., Guichard, C., Ladeiro, Y., Sedghi, S., Vallée, M., Fernandez, N., Bruyère, E., Woerther, P.-L., Ducroc, R., Montcuquet, N., Freund, J.-N., Van Seuningen, I., Barreau, F., Marah, A., Hugot, J.-P., Cazals-Hatem, D., Bouhnik, Y., Daniel, F., & Ogier-Denis, E. (2014). Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PloS One, 9(7), e101669. https://doi.org/10.1371/journal.pone.0101669

Bellis, J., Duluc, I., Freund, J.-N., & De Mey, J. R. (2013). Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum. Bio-Protocol, 3(20), e942. www.bio-protocol.org/e942

Derbal-Wolfrom, L., Pencreach, E., Saandi, T., Aprahamian, M., Martin, E., Greferath, R., Tufa, E., Choquet, P., Lehn, J.-M., Nicolau, C., Duluc, I., & Freund, J.-N. (2013). Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. Oncogene, 32(36), 4313–4318. https://doi.org/10.1038/onc.2012.445

Saandi, T., Baraille, F., Derbal-Wolfrom, L., Cattin, A.-L., Benahmed, F., Martin, E., Cardot, P., Duclos, B., Ribeiro, A., Freund, J.-N., & Duluc, I. (2013). Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene, 32(32), 3782–3788. https://doi.org/10.1038/onc.2012.401

Chery, C., Hehn, A., Mrabet, N., Oussalah, A., Jeannesson, E., Besseau, C., Alberto, J.-M., Gross, I., Josse, T., Gérard, P., Guéant-Rodriguez, R. M., Freund, J.-N., Devignes, J., Bourgaud, F., Peyrin-Biroulet, L., Feillet, F., & Guéant, J.-L. (2013). Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. Biochimie, 95(5), 995–1001. https://doi.org/10.1016/j.biochi.2013.01.022

Guéant, J.-L., Caillerez-Fofou, M., Battaglia-Hsu, S., Alberto, J.-M., Freund, J.-N., Duluc, I., Adjalla, C., Maury, F., Merle, C., Nicolas, J.-P., Namour, F., & Daval, J.-L. (2013). Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie, 95(5), 1033–1040. https://doi.org/10.1016/j.biochi.2013.01.020

De Mey, J. R., & Freund, J.-N. (2013). Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers, 1(2), e24965. https://doi.org/10.4161/tisb.24965

Pereira, B., Sousa, S., Barros, R., Carreto, L., Oliveira, P., Oliveira, C., Chartier, N. T., Plateroti, M., Rouault, J.-P., Freund, J.-N., Billaud, M., & Almeida, R. (2013). CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Research, 41(7), 3986–3999. https://doi.org/10.1093/nar/gkt087

Badique, F., Stamov, D. R., Davidson, P. M., Veuillet, M., Reiter, G., Freund, J.-N., Franz, C. M., & Anselme, K. (2013). Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization. Biomaterials, 34(12), 2991–3001. https://doi.org/10.1016/j.biomaterials.2013.01.018

Rabineau, M., Kocgozlu, L., Dujardin, D., Senger, B., Haikel, Y., Voegel, J.-C., Freund, J.-N., Schaaf, P., Lavalle, P., & Vautier, D. (2013). Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division. PloS One, 8(10), e78468. https://doi.org/10.1371/journal.pone.0078468

Freund, J.-N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Annales De Pathologie, 32(5 Suppl), S24-27. https://doi.org/10.1016/j.annpat.2012.08.005

Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in Molecular Medicine, 18(9), 555–563. https://doi.org/10.1016/j.molmed.2012.07.006

Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A., & Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. Journal of Biological Regulators and Homeostatic Agents, 26(3), 515–526.