Laurent VALLAT

Assistant Professor / MD

ORCID – ResearcherID





List of publications :


El Omar, R., Julien, E., Biasch, K., Guffroy, B., Lioure, B., Vallat, L., Gross, I., Domon-Dell, C., Lanza, F., Gachet, C., Negroni, M., Freund, J.-N., & Tavian, M. (2021). CDX2 regulates ACE expression in blood development and leukemia cells. Blood Advances, 5(7), 2012–2016.
Bertrand, F., Aouadi, I., Jung, N., Carapito, R., Vallat, L., Bahram, S., & Maumy-Bertrand, M. (2020, October 5). SelectBoost: a general algorithm to enhance the performance of variable selection methods. Bioinformatics (Oxford, England).
Fornecker, L.-M., Muller, L., Bertrand, F., Paul, N., Pichot, A., Herbrecht, R., Chenard, M.-P., Mauvieux, L., Vallat, L., Bahram, S., Cianférani, S., Carapito, R., & Carapito, C. (2019). Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma. Scientific Reports, 9(1), 895.
Schleiss, C., Ilias, W., Tahar, O., Güler, Y., Miguet, L., Mayeur-Rousse, C., Mauvieux, L., Fornecker, L.-M., Toussaint, E., Herbrecht, R., Bertrand, F., Maumy-Bertrand, M., Martin, T., Fournel, S., Georgel, P., Bahram, S., & Vallat, L. (2019). BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo. Scientific Reports, 9(1), 701.
Alsaleh, G., Nehmar, R., Blüml, S., Schleiss, C., Ostermann, E., Dillenseger, J.-P., Sayeh, A., Choquet, P., Dembele, D., Francois, A., Salmon, J.-H., Paul, N., Schabbauer, G., Bierry, G., Meyer, A., Gottenberg, J.-E., Haas, G., Pfeffer, S., Vallat, L., … Georgel, P. (2016). Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli. Arthritis & Rheumatology (Hoboken, N.J.), 68(8), 1839–1848.
Reix, N., Agin, A., Bahram, S., Dali-Youcef, N., Grucker, D., Jaulhac, B., Lepiller, Q., Lessinger, J.-M., Mauvieux, L., Monier, L., Schramm, F., Stoll-Keller, F., Vallat, L., Ludes, B., Candolfi, E., & Filisetti, D. (2015). [Clinical laboratory medicine: continuous amelioration with a book of objectives and satisfaction survey]. Annales De Biologie Clinique, 73(3), 359–368.
Le Loarer, F., Barete, S., Vallat, L., Carre, D., El Amarti, R., Torres-Cabala, C., Cacoub, P., Sene, D., Courville, P., & Bravard, P. (2014). Primary cutaneous CD8+ T-cell lymphoma masquerading as acral vascular syndrome. Acta Dermato-Venereologica, 94(3), 317–319.
Jung, N., Bertrand, F., Bahram, S., Vallat, L., & Maumy-Bertrand, M. (2014). Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network. Bioinformatics (Oxford, England), 30(4), 571–573.
Vallat, L., Kemper, C. A., Jung, N., Maumy-Bertrand, M., Bertrand, F., Meyer, N., Pocheville, A., Fisher, J. W., Gribben, J. G., & Bahram, S. (2013). Reverse-engineering the genetic circuitry of a cancer cell with predicted intervention in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110(2), 459–464.
Perrot, A., Pionneau, C., Azar, N., Baillou, C., Lemoine, F. M., Leblond, V., Merle-Béral, H., Béné, M.-C., Herbrecht, R., Bahram, S., & Vallat, L. (2012). Waldenström’s macroglobulinemia harbors a unique proteome where Ku70 is severely underexpressed as compared with other B-lymphoproliferative disorders. Blood Cancer Journal, 2, e88.
Perrot, A., Pionneau, C., Nadaud, S., Davi, F., Leblond, V., Jacob, F., Merle-Béral, H., Herbrecht, R., Béné, M.-C., Gribben, J. G., Bahram, S., & Vallat, L. (2011). A unique proteomic profile on surface IgM ligation in unmutated chronic lymphocytic leukemia. Blood, 118(4), e1-15.
Grassin-Delyle, S., Buenestado, A., Vallat, L., Naline, E., Marx, S., Decocq, J., Debré, P., Bernard, O. A., Advenier, C., Devillier, P., & Merle-Béral, H. (2011). Expression and proliferative effect of hemokinin-1 in human B-cells. Peptides, 32(5), 1027–1034.
Marteau, J.-B., Rigaud, O., Brugat, T., Gault, N., Vallat, L., Kruhoffer, M., Orntoft, T. F., Nguyen-Khac, F., Chevillard, S., Merle-Beral, H., & Delic, J. (2010). Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males. BMC Medical Genomics, 3, 53.
Buchner, M., Fuchs, S., Prinz, G., Pfeifer, D., Bartholomé, K., Burger, M., Chevalier, N., Vallat, L., Timmer, J., Gribben, J. G., Jumaa, H., Veelken, H., Dierks, C., & Zirlik, K. (2009). Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Research, 69(13), 5424–5432.
Praz, F., Le Page, F., Vallat, L., Davi, F., Nguyen-Khac, F., Maloum, K., Delic, J., & Merle-Béral, H. (2008). Absence of microsatellite instability in human chronic lymphocytic leukaemia B cells. Leukemia, 22(1), 186–189.
Vallat, L. D., Park, Y., Li, C., & Gribben, J. G. (2007). Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells. Blood, 109(9), 3989–3997.
Vasconcelos, Y., De Vos, J., Vallat, L., Rème, T., Lalanne, A. I., Wanherdrick, K., Michel, A., Nguyen-Khac, F., Oppezzo, P., Magnac, C., Maloum, K., Ajchenbaum-Cymbalista, F., Troussard, X., Leporrier, M., Klein, B., Dighiero, G., Davi, F., & French Cooperative Group on CLL. (2005). Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genes. Leukemia, 19(11), 2002–2005.
Rigolet, A., Cacoub, P., Schnuriger, A., Vallat, L., Cahour, A., Ghillani, P., Davi, F., Benhamou, Y., Piette, J.-C., & Thibault, V. (2005). Genetic heterogeneity of the hypervariable region I of Hepatitis C virus and lymphoproliferative disorders. Leukemia, 19(6), 1070–1076.
Vallat, L., Benhamou, Y., Gutierrez, M., Ghillani, P., Hercher, C., Thibault, V., Charlotte, F., Piette, J.-C., Poynard, T., Merle-Béral, H., Davi, F., & Cacoub, P. (2004). Clonal B cell populations in the blood and liver of patients with chronic hepatitis C virus infection. Arthritis and Rheumatism, 50(11), 3668–3678.
Guipaud, O., Deriano, L., Salin, H., Vallat, L., Sabatier, L., Merle-Béral, H., & Delic, J. (2003). B-cell chronic lymphocytic leukaemia: a polymorphic family unified by genomic features. The Lancet. Oncology, 4(8), 505–514.
Vallat, L., Magdelénat, H., Merle-Béral, H., Masdehors, P., Potocki de Montalk, G., Davi, F., Kruhoffer, M., Sabatier, L., Orntoft, T. F., & Delic, J. (2003). The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays. Blood, 101(11), 4598–4606.