Michelina PLATEROTI

DR2 Inserm ; Team 3 Leader

ORCID – ResearcherID

(+33) 03 88 27 53 56

List of publications:

Giolito, M. V., Claret, L., Frau, C., & Plateroti, M. (2021). A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells. JoVE (Journal of Visualized Experiments), 167, e61783. https://doi.org/10.3791/61783
Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Neve, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., Fouchardière, C. de la, & Plateroti, M. (2021). Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2450
Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Nevé, C. L., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway. Development. https://doi.org/10.1242/dev.194357
Baroni, M., Yi, C., Choudhary, S., Lei, X., Kosti, A., Grieshober, D., Velasco, M., Qiao, M., Burns, S. S., Araujo, P. R., DeLambre, T., Son, M. Y., Plateroti, M., Ferreira, M. A. R., Hasty, P., & Penalva, L. O. F. (2021). Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes. Cancers, 13(7), 1494. https://doi.org/10.3390/cancers13071494
Ducheix, S., Peres, C., Härdfeldt, J., Frau, C., Mocciaro, G., Piccinin, E., Lobaccaro, J.-M., De Santis, S., Chieppa, M., Bertrand-Michel, J., Plateroti, M., Griffin, J. L., Sabbà, C., Ntambi, J. M., & Moschetta, A. (2018). Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate. Gastroenterology, 155(5), 1524-1538.e9. https://doi.org/10.1053/j.gastro.2018.07.032
Plantamura, E., Dzutsev, A., Chamaillard, M., Djebali, S., Moudombi, L., Boucinha, L., Grau, M., Macari, C., Bauché, D., Dumitrescu, O., Rasigade, J.-P., Lippens, S., Plateroti, M., Kress, E., Cesaro, A., Bondu, C., Rothermel, U., Heikenwälder, M., Lina, G., … Michallet, M.-C. (2018). MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype. Proceedings of the National Academy of Sciences of the United States of America, 115(41), 10404–10409. https://doi.org/10.1073/pnas.1722372115
Uchuya-Castillo, J., Aznar, N., Frau, C., Martinez, P., Le Nevé, C., Marisa, L., Penalva, L. O. F., Laurent-Puig, P., Puisieux, A., Scoazec, J.-Y., Samarut, J., Ansieau, S., & Plateroti, M. (2018). Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity. Oncotarget, 9(57), 30979–30996. https://doi.org/10.18632/oncotarget.25741
Markossian, S., Guyot, R., Richard, S., Teixeira, M., Aguilera, N., Bouchet, M., Plateroti, M., Guan, W., Gauthier, K., Aubert, D., & Flamant, F. (2018). CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone. Thyroid: Official Journal of the American Thyroid Association, 28(1), 139–150. https://doi.org/10.1089/thy.2017.0389
Sirakov, M., & Plateroti, M. (2018). In Vitro Approaches to Identify Thyroid Hormone Receptor-Dependent Transcriptional Response. Methods in Molecular Biology (Clifton, N.J.), 1801, 29–38. https://doi.org/10.1007/978-1-4939-7902-8_4
Samarut, J., & Plateroti, M. (2018). Thyroid Hormone Receptors: Several Players for One Hormone and Multiple Functions. Methods in Molecular Biology (Clifton, N.J.), 1801, 1–8. https://doi.org/10.1007/978-1-4939-7902-8_1
Frau, C., Godart, M., & Plateroti, M. (2017). Thyroid hormone regulation of intestinal epithelial stem cell biology. Molecular and Cellular Endocrinology, 459, 90–97. https://doi.org/10.1016/j.mce.2017.03.002
Skah, S., Uchuya-Castillo, J., Sirakov, M., & Plateroti, M. (2017). The thyroid hormone nuclear receptors and the Wnt/β-catenin pathway: An intriguing liaison. Developmental Biology, 422(2), 71–82. https://doi.org/10.1016/j.ydbio.2017.01.003
Perra, A., Plateroti, M., & Columbano, A. (2016). T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair. Endocrine-Related Cancer, 23(8), R353-369. https://doi.org/10.1530/ERC-16-0152
Cambuli, F. M., Correa, B. R., Rezza, A., Burns, S. C., Qiao, M., Uren, P. J., Kress, E., Boussouar, A., Galante, P. a. F., Penalva, L. O. F., & Plateroti, M. (2015). A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness. Stem Cells (Dayton, Ohio), 33(12), 3621–3634. https://doi.org/10.1002/stem.2202
Sirakov, M., Boussouar, A., Kress, E., Frau, C., Lone, I. N., Nadjar, J., Angelov, D., & Plateroti, M. (2015). The thyroid hormone nuclear receptor TRα1 controls the Notch signaling pathway and cell fate in murine intestine. Development (Cambridge, England), 142(16), 2764–2774. https://doi.org/10.1242/dev.121962
Ozmadenci, D., Féraud, O., Markossian, S., Kress, E., Ducarouge, B., Gibert, B., Ge, J., Durand, I., Gadot, N., Plateroti, M., Bennaceur-Griscelli, A., Scoazec, J.-Y., Gil, J., Deng, H., Bernet, A., Mehlen, P., & Lavial, F. (2015). Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance. Nature Communications, 6, 7398. https://doi.org/10.1038/ncomms8398
Skah, S., Nadjar, J., Sirakov, M., & Plateroti, M. (2015). The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium. Experimental Cell Research, 330(1), 56–65. https://doi.org/10.1016/j.yexcr.2014.10.014
Sirakov, M., Kress, E., Nadjar, J., & Plateroti, M. (2014). Thyroid hormones and their nuclear receptors: new players in intestinal epithelium stem cell biology? Cellular and Molecular Life Sciences: CMLS, 71(15), 2897–2907. https://doi.org/10.1007/s00018-014-1586-3
Lapierre, M., Bonnet, S., Bascoul-Mollevi, C., Ait-Arsa, I., Jalaguier, S., Del Rio, M., Plateroti, M., Roepman, P., Ychou, M., Pannequin, J., Hollande, F., Parker, M., & Cavailles, V. (2014). RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. The Journal of Clinical Investigation, 124(5), 1899–1913. https://doi.org/10.1172/JCI65178
Pastò, A., Serafin, V., Pilotto, G., Lago, C., Bellio, C., Trusolino, L., Bertotti, A., Hoey, T., Plateroti, M., Esposito, G., Pinazza, M., Agostini, M., Nitti, D., Amadori, A., & Indraccolo, S. (2014). NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells. Cancer Research, 74(7), 2106–2118. https://doi.org/10.1158/0008-5472.CAN-13-2022
Berthon, A., Drelon, C., Ragazzon, B., Boulkroun, S., Tissier, F., Amar, L., Samson-Couterie, B., Zennaro, M.-C., Plouin, P.-F., Skah, S., Plateroti, M., Lefèbvre, H., Sahut-Barnola, I., Batisse-Lignier, M., Assié, G., Lefrançois-Martinez, A.-M., Bertherat, J., Martinez, A., & Val, P. (2014). WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production. Human Molecular Genetics, 23(4), 889–905. https://doi.org/10.1093/hmg/ddt484
Maria Cambuli, F., Rezza, A., Nadjar, J., & Plateroti, M. (2013). Brief report: musashi1-eGFP mice, a new tool for differential isolation of the intestinal stem cell populations. Stem Cells (Dayton, Ohio), 31(10), 2273–2278. https://doi.org/10.1002/stem.1428
Sirakov, M., Skah, S., Nadjar, J., & Plateroti, M. (2013). Thyroid hormone’s action on progenitor/stem cell biology: new challenge for a classic hormone? Biochimica Et Biophysica Acta, 1830(7), 3917–3927. https://doi.org/10.1016/j.bbagen.2012.07.014
Sirakov, M., Borra, M., Cambuli, F. M., & Plateroti, M. (2013). Defining suitable reference genes for RT-qPCR analysis on intestinal epithelial cells. Molecular Biotechnology, 54(3), 930–938. https://doi.org/10.1007/s12033-012-9643-3
Pereira, B., Sousa, S., Barros, R., Carreto, L., Oliveira, P., Oliveira, C., Chartier, N. T., Plateroti, M., Rouault, J.-P., Freund, J.-N., Billaud, M., & Almeida, R. (2013). CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Research, 41(7), 3986–3999. https://doi.org/10.1093/nar/gkt087
Diala, I., Wagner, N., Magdinier, F., Shkreli, M., Sirakov, M., Bauwens, S., Schluth-Bolard, C., Simonet, T., Renault, V. M., Ye, J., Djerbi, A., Pineau, P., Choi, J., Artandi, S., Dejean, A., Plateroti, M., & Gilson, E. (2013). Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Reports, 14(4), 356–363. https://doi.org/10.1038/embor.2013.16
Plateroti, M., de Araujo, P. R., da Silva, A. E., & Penalva, L. O. F. (2012). The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development. Current Colorectal Cancer Reports, 8(4), 290–297. https://doi.org/10.1007/s11888-012-0141-6
Sirakov, M., & Plateroti, M. (2011). The thyroid hormones and their nuclear receptors in the gut: from developmental biology to cancer. Biochimica Et Biophysica Acta, 1812(8), 938–946. https://doi.org/10.1016/j.bbadis.2010.12.020
Plateroti, M., Bernal, J., Refetoff, S., & Sachs, L. (2011). Thyroid hormones and their receptors: from development to disease. Journal of Thyroid Research, 2011, 284737. https://doi.org/10.4061/2011/284737
Rezza, A., Skah, S., Roche, C., Nadjar, J., Samarut, J., & Plateroti, M. (2010). The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. Journal of Cell Science, 123(Pt 19), 3256–3265. https://doi.org/10.1242/jcs.065284
Kowalik, M. A., Perra, A., Pibiri, M., Cocco, M. T., Samarut, J., Plateroti, M., Ledda-Columbano, G. M., & Columbano, A. (2010). TRbeta is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells. Journal of Hepatology, 53(4), 686–692. https://doi.org/10.1016/j.jhep.2010.04.028
Kress, E., Skah, S., Sirakov, M., Nadjar, J., Gadot, N., Scoazec, J.-Y., Samarut, J., & Plateroti, M. (2010). Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis. Gastroenterology, 138(5), 1863–1874. https://doi.org/10.1053/j.gastro.2010.01.041
Plateroti, M., Gauthier, K., Domon-Dell, C., Freund, J. N., Samarut, J., & Chassande, O. (2001). Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development. Molecular and Cellular Biology, 21(14), 4761–4772. https://doi.org/10.1128/MCB.21.14.4761-4772.2001
Plateroti, M., Chassande, O., Fraichard, A., Gauthier, K., Freund, J. N., Samarut, J., & Kedinger, M. (1999). Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development. Gastroenterology, 116(6), 1367–1378.
Kedinger, M., Duluc, I., Fritsch, C., Lorentz, O., Plateroti, M., & Freund, J. N. (1998). Intestinal epithelial-mesenchymal cell interactions. Annals of the New York Academy of Sciences, 859, 1–17.
Plateroti, M., Rubin, D. C., Duluc, I., Singh, R., Foltzer-Jourdainne, C., Freund, J. N., & Kedinger, M. (1998). Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics. The American Journal of Physiology, 274(5 Pt 1), G945-954.
Plateroti, M., Freund, J. N., Leberquier, C., & Kedinger, M. (1997). Mesenchyme-mediated effects of retinoic acid during rat intestinal development. Journal of Cell Science, 110 ( Pt 10), 1227–1238.
Kedinger, M., Plateroti, M., Orian-Rousseau, V., Lorentz, O., Fritsch, C., De Arcangelis, A., Evans, G., Duluc, I., Freund, J. N., & Simon-Assmann, P. (1997). Cellular and molecular mechanisms regulating intestinal development (F. Halter, D. Winton, & N. A. Wright, Eds.; Vol. 94). Springer.