This translational study shows that the transcription factor CDX2, which plays an essential role in the identity of intestinal cells, decreases the sensitivity to chemotherapy of patients with colorectal cancer by promoting the expression of genes involved in the elimination of cytotoxic molecules. It therefore opens the way to the development of new, more effective…Continue reading 03/2022 : New publication (Jean-Baptiste DELHORME / Isabelle GROSS)

This study unravels the mechanisms of regulation of the atypical cadherin MUCDHL, namely by mesalazine which is used to treat chronic inflammatory diseases. The results obtained highlight the importance of the cellular and molecular context in the activity of mesalazine and suggest that its chemopreventive activity against colorectal cancer depends on the genetic alterations of…Continue reading 02/2022 : New publication (Emilie BERSUDER / Isabelle GROSS)

December 2021 : Sirakov M, Claret L, Plateroti M. Thyroid Hormone Nuclear Receptor TRα1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer. Front Endocrinol (Lausanne). 2021 Dec 10;12:725708. doi: 10.3389/fendo.2021.725708. eCollection 2021. PMID: 34956074 January 2022 : Sirakov M and Plateroti M. Thyroid Hormone Signaling and Function: News from Classical and Emerging Models. Cells 2022, 11(3),…Continue reading 01/2022: 2 new publications for Michelina PLATEROTI’s team

12/17/2021: Thesis defense by Ava Galland: Function and regulation of the homeotic Cdx2 gene in acute leukemia

17/12/2021: Seminar of Professor Eric Solary, Institut Gustave Roussy, Villejuif: Chronic myelomonocytic leukemia: should we target mature cells of the clone?

12/06/2021: Thesis defense by Susanna Borreill: The Basic Transcriptional Machinery in Intestinal Homeostasis

09/11/2021: 21st Regional Scientific Day of the League against Cancer. Scientific program established by JN Freund

09/24/2021: 1st ITI Innovec Summer School: Understanding stem cells and their environments for efficient targeting. Scientific program established by JN Freund

Inserm magazine N 50 pg. 10. The publication in Cancer Research (Frau et al, 2021) is summarized in the “It’s our health” section, Colorectal cancer: MSI1, a marker of interest in chemoresistance.

Interview with Michelina PLATEROTI published in the weekly newsletter of INSERM EST on May 21, 2021, about the arrival of her team in unit 1113 and the publication of her work in the journal Cancer Research. To read here: http://www.est.inserm.fr/actualites/cancers-colorectaux-pourquoi-les-cellules-souches-cancereuses-echappent-a-la-chimiotherapie