Publications Jean-Noël FREUND before 2013

Freund, J.-N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Annales De Pathologie, 32(5 Suppl), S24-27. https://doi.org/10.1016/j.annpat.2012.08.005
Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in Molecular Medicine, 18(9), 555–563. https://doi.org/10.1016/j.molmed.2012.07.006
Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A., & Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. Journal of Biological Regulators and Homeostatic Agents, 26(3), 515–526.
Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., … De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341. https://doi.org/10.1083/jcb.201204086
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., … Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469. https://doi.org/10.1093/nar/gkr1242
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., … Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474. https://doi.org/10.1242/dev.070722
Kocgozlu, L., Rabineau, M., Koenig, G., Haikel, Y., Schaaf, P., Freund, J.-N., … Vautier, D. (2012). The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity. Biomaterials, 33(3), 798–809. https://doi.org/10.1016/j.biomaterials.2011.10.024
Reimund, J.-M., Tavernier, M., Viennot, S., Hussein, I. A. H., Dupont, B., Justum, A.-M., … Lechevrel, M. (2012). Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives. https://doi.org/10.5772/25577
van de Ven, C., Bialecka, M., Neijts, R., Young, T., Rowland, J. E., Stringer, E. J., … Deschamps, J. (2011). Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development (Cambridge, England), 138(16), 3451–3462. https://doi.org/10.1242/dev.066118
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298. https://doi.org/10.1136/gut.2010.222323
Laurent, C., Svrcek, M., Flejou, J.-F., Chenard, M.-P., Duclos, B., Freund, J.-N., & Reimund, J.-M. (2011). Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. Inflammatory Bowel Diseases, 17(1), 232–240. https://doi.org/10.1002/ibd.21451
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., … Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., … Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727. https://doi.org/10.1542/peds.2009-3512
Coant, N., Ben Mkaddem, S., Pedruzzi, E., Guichard, C., Tréton, X., Ducroc, R., … Ogier-Denis, E. (2010). NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Molecular and Cellular Biology, 30(11), 2636–2650. https://doi.org/10.1128/MCB.01194-09
Barros, R., Camilo, V., Pereira, B., Freund, J.-N., David, L., & Almeida, R. (2010). Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochemical Society Transactions, 38(2), 358–363. https://doi.org/10.1042/BST0380358
Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., … Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell, 17(4), 516–526. https://doi.org/10.1016/j.devcel.2009.08.010
Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M.-T., Valanzano, R., … Moschetta, A. (2009). Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut, 58(9), 1250–1259. https://doi.org/10.1136/gut.2008.158386
Pons, L., Battaglia-Hsu, S.-F., Orozco-Barrios, C. E., Ortiou, S., Chery, C., Alberto, J.-M., … Gueant, J.-L. (2009). Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. PloS One, 4(7), e6325. https://doi.org/10.1371/journal.pone.0006325
Salehi, S., Eckley, L., Sawyer, G. J., Zhang, X., Dong, X., Freund, J.-N., & Fabre, J. W. (2009). Intestinal lactase as an autologous beta-galactosidase reporter gene for in vivo gene expression studies. Human Gene Therapy, 20(1), 21–30. https://doi.org/10.1089/hum.2008.101
Benahmed, F., Gross, I., Gaunt, S. J., Beck, F., Jehan, F., Domon-Dell, C., … Duluc, I. (2008). Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology, 135(4), 1238–1247, 1247.e1-3. https://doi.org/10.1053/j.gastro.2008.06.045
Barros, R., Pereira, B., Duluc, I., Azevedo, M., Mendes, N., Camilo, V., … Almeida, R. (2008). Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. The Journal of Pathology, 215(4), 411–420. https://doi.org/10.1002/path.2369
Bonhomme, C., Calon, A., Martin, E., Robine, S., Neuville, A., Kedinger, M., … Freund, J.-N. (2008). Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene, 27(32), 4497–4502. https://doi.org/10.1038/onc.2008.78
Hajj Hussein, I.-A., Tohme, R., Barada, K., Mostafa, M. H., Freund, J.-N., Jurjus, R. A., … Jurjus, A. (2008). Inflammatory bowel disease in rats: bacterial and chemical interaction. World Journal of Gastroenterology, 14(25), 4028–4039.
Lu, X., Freund, J.-N., Muller, M., Ravey, J., Nicolas, J.-P., Gueant, J.-L., & Namour, F. (2008). Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. Biochimie, 90(5), 697–704. https://doi.org/10.1016/j.biochi.2007.12.002
Gross, I., Duluc, I., Benameur, T., Calon, A., Martin, E., Brabletz, T., … Freund, J.-N. (2008). The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene, 27(1), 107–115. https://doi.org/10.1038/sj.onc.1210601
Reimund, J.-M., & Freund, J.-N. (2008). Inflammatory Bowel Disease-associated Cancer. In M. Schwab (Ed.), Encyclopedia of Cancer (pp. 1525–1528). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_3046
Calon, A., Gross, I., Lhermitte, B., Martin, E., Beck, F., Duclos, B., … Freund, J.-N. (2007). Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut, 56(12), 1688–1695. https://doi.org/10.1136/gut.2007.125542
Choquet, P., Calon, A., Breton, E., Beck, F., Domon-Dell, C., Freund, J.-N., & Constantinesco, A. (2007). Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. Comptes Rendus Biologies, 330(11), 821–827. https://doi.org/10.1016/j.crvi.2007.08.002
Gross, I., Armant, O., Benosman, S., de Aguilar, J. L. G., Freund, J.-N., Kedinger, M., … Loeffler, J.-P. (2007). Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell Death and Differentiation, 14(10), 1802–1812. https://doi.org/10.1038/sj.cdd.4402188
Jonckheere, N., Vincent, A., Perrais, M., Ducourouble, M.-P., Male, A. K., Aubert, J.-P., … Van Seuningen, I. (2007). The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. The Journal of Biological Chemistry, 282(31), 22638–22650. https://doi.org/10.1074/jbc.M700905200
Coste, I., Freund, J.-N., Spaderna, S., Brabletz, T., & Renno, T. (2007). Precancerous lesions upon sporadic activation of beta-catenin in mice. Gastroenterology, 132(4), 1299–1308. https://doi.org/10.1053/j.gastro.2007.01.029
Subtil, C., Guérin, E., Schneider, A., Chenard, M.-P., Martin, E., Domon-Dell, C., … Freund, J.-N. (2007). Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Letters, 247(2), 197–203. https://doi.org/10.1016/j.canlet.2006.04.004
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., … Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744. https://doi.org/10.2353/ajpath.2007.060696
Calon, A., Gross, I., Davidson, I., Kedinger, M., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2007). Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Research, 35(1), 175–185. https://doi.org/10.1093/nar/gkl1034
Buchet-Poyau, K., Courchet, J., Le Hir, H., Séraphin, B., Scoazec, J.-Y., Duret, L., … Billaud, M. (2007). Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Research, 35(4), 1289–1300. https://doi.org/10.1093/nar/gkm016
Debruyne, P. R., Witek, M., Gong, L., Birbe, R., Chervoneva, I., Jin, T., … Waldman, S. A. (2006). Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology, 130(4), 1191–1206. https://doi.org/10.1053/j.gastro.2005.12.032
Kim, H.-S., Lee, J.-S., Freund, J.-N., Min, K.-W., Lee, J.-S., Kim, W., … Park, C.-S. (2006). CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions. Journal of Gastroenterology and Hepatology, 21(2), 438–442. https://doi.org/10.1111/j.1440-1746.2005.03933.x
Gross, I., Lhermitte, B., Domon-Dell, C., Duluc, I., Martin, E., Gaiddon, C., … Freund, J.-N. (2005). Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene, 24(54), 7955–7963. https://doi.org/10.1038/sj.onc.1208945
Turck, N., Gross, I., Gendry, P., Stutzmann, J., Freund, J.-N., Kedinger, M., … Launay, J.-F. (2005). Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Experimental Cell Research, 303(2), 494–503. https://doi.org/10.1016/j.yexcr.2004.10.025
Kedinger, M., & Freund, J.-N. (2005). Gut Epithelium. In Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (pp. 736–739). Springer Berlin Heidelberg. https://doi.org/10.1007/3-540-29623-9_3310
Wang, L., Klopot, A., Freund, J.-N., Dowling, L. N., Krasinski, S. D., & Fleet, J. C. (2004). Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. American Journal of Physiology. Gastrointestinal and Liver Physiology, 287(5), G943-953. https://doi.org/10.1152/ajpgi.00121.2004
Brabletz, T., Spaderna, S., Kolb, J., Hlubek, F., Faller, G., Bruns, C. J., … Freund, J.-N. (2004). Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Research, 64(19), 6973–6977. https://doi.org/10.1158/0008-5472.CAN-04-1132
Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., … Jay, P. (2004). SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology, 166(1), 37–47. https://doi.org/10.1083/jcb.200311021
Tohyama, O., Imura, A., Iwano, A., Freund, J.-N., Henrissat, B., Fujimori, T., & Nabeshima, Y. (2004). Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. The Journal of Biological Chemistry, 279(11), 9777–9784. https://doi.org/10.1074/jbc.M312392200
Kim, S.-P., Park, J.-W., Lee, S.-H., Lim, J. H., Jang, B.-C., Lee, S.-H., … Kwon, T. K. (2004). Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. Biochemical and Biophysical Research Communications, 315(1), 93–99. https://doi.org/10.1016/j.bbrc.2004.01.020
Kim, S., Domon-Dell, C., Kang, J., Chung, D. H., Freund, J.-N., & Evers, B. M. (2004). Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. The Journal of Biological Chemistry, 279(6), 4285–4291. https://doi.org/10.1074/jbc.M308383200
Reimund, Jean-Marie, Laurent, Camille, Chenard, M.-P., Bellocq, Jean-Pierre, Freund, J.-N., Kedinger, Michèle, … Baumann René. (2003). Cancer colorectal au cours de la rectocolite hémorragique. Hépato-Gastro, 6(10), 415–423.
Bonhomme, C., Duluc, I., Martin, E., Chawengsaksophak, K., Chenard, M.-P., Kedinger, M., … Domon-Dell, C. (2003). The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut, 52(10), 1465–1471.
Gautier-Stein, A., Domon-Dell, C., Calon, A., Bady, I., Freund, J.-N., Mithieux, G., & Rajas, F. (2003). Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2. Nucleic Acids Research, 31(18), 5238–5246.