Christophe ORVAIN

IE2 INSERM ; Personne Compétente en Radioactivité

ORCID – ResearcherID

(+33) 03 88 27 53 60




Liste des publications :


Miller, J. J., Blanchet, A., Orvain, C., Nouchikian, L., Reviriot, Y., Clarke, R. M., Martelino, D., Wilson, D., Gaiddon, C., & Storr, T. (2019). Bifunctional ligand design for modulating mutant p53 aggregation in cancer. Chemical Science, 10(46), 10802–10814.
Spaety, M.-E., Gries, A., Badie, A., Venkatasamy, A., Romain, B., Orvain, C., Yanagihara, K., Okamoto, K., Jung, A. C., Mellitzer, G., Pfeffer, S., & Gaiddon, C. (2019). HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers, 11(11), 1747.
Miller, J. J., Orvain, C., Jozi, S., Clarke, R. M., Smith, J. R., Blanchet, A., Gaiddon, C., Warren, J. J., & Storr, T. (2018). Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer. Chemistry (Weinheim an Der Bergstrasse, Germany), 24(67), 17734–17742.
Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., Orvain, C., Hejl, M., Hanif, M., Jakupec, M. A., Keppler, B. K., Gaiddon, C., & Hartinger, C. G. (2018). Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry, 57(5), 2851–2864.
Khalil, G., Orvain, C., Fang, L., Barloy, L., Chaumont, A., Gaiddon, C., Henry, M., Kyritsakas, N., & Mobian, P. (2016). Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities. Dalton Transactions (Cambridge, England: 2003), 45(47), 19072–19085.
Nivlet, L., Herrmann, J., Martin, D. E., Meunier, A., Orvain, C., & Gradwohl, G. (2016). Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas. Journal of Molecular Endocrinology, 56(2), 77–90.
Rico Bautista, H., Saavedra Díaz, R. O., Shen, L. Q., Orvain, C., Gaiddon, C., Le Lagadec, R., & Ryabov, A. D. (2016). Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells. Journal of Inorganic Biochemistry, 163, 28–38.
Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M. L., Mellitzer, G., & Gradwohl, G. (2010). Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England), 137(2), 203–212.
Orvain, C., Matre, V., & Gabrielsen, O. S. (2008). The transcription factor c-Myb affects pre-mRNA splicing. Biochemical and Biophysical Research Communications, 372(2), 309–313.
Martin, M., Hauer, V., Messmer, M., Orvain, C., & Gradwohl, G. (2007). Transcription factors in pancreatic development. Animal models. Endocrine Development, 12, 24–32.
Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P. A., Sander, M., & Gradwohl, G. (2004). Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice. Molecular Endocrinology (Baltimore, Md.), 18(11), 2765–2776.
Delva, L., Gallais, I., Guillouf, C., Denis, N., Orvain, C., & Moreau-Gachelin, F. (2004). Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells. Oncogene, 23(25), 4389–4399.
Matre, V., Høvring, P. I., Fjeldheim, A.-K., Helgeland, L., Orvain, C., Andersson, K. B., Gautvik, K. M., & Gabrielsen, O. S. (2003). The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb. The Biochemical Journal, 372(Pt 3), 851–859.
Orvain, C., & Gabrielsen, O. (2001). Mise en évidence de l’implication du facteur de transcription c-Myb dans l’épissage des ARNs pre-messagers. Bulletin Scientifique de l’Ambassade de France En Norvege.
Lerga, A., Hallier, M., Delva, L., Orvain, C., Gallais, I., Marie, J., & Moreau-Gachelin, F. (2001). Identification of an RNA binding specificity for the potential splicing factor TLS. The Journal of Biological Chemistry, 276(9), 6807–6816.
Céraline, J., Deplanque, G., Duclos, B., Limacher, J. M., Hajri, A., Noel, F., Orvain, C., Frébourg, T., Klein-Soyer, C., & Bergerat, J. P. (1998). Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents. International Journal of Cancer, 75(3), 432–438.<432::aid-ijc17>;2-a
Klein-Soyer, C., Duhamel-Clérin, E., Ravanat, C., Orvain, C., Lanza, F., & Cazenave, J.-P. (1997). PF4 inhibits thrombin-stimulated MMP-1 and MMP-3 metalloproteinase expression in human vascular endothelial cells. Comptes Rendus de l’Académie Des Sciences - Series III - Sciences de La Vie, 320(11), 857–868.
Duhamel-Clérin, E., Orvain, C., Lanza, F., Cazenave, J.-P., & Klein-Soyer, C. (1997). Thrombin Receptor-Mediated Increase of Two Matrix Metalloproteinases, MMP-1 and MMP-3, in Human Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(10), 1931–1938.
Klein-Soyer, C., Céraline, J., Orvain, C., de la Salle, C., Bergerat, J. P., & Cazenave, J. P. (1997). Angiogenesis inhibitor SR 25989 upregulates thrombospondin-1 expression in human vascular endothelial cells and foreskin fibroblasts. Biology of the Cell, 89(4), 295–307.
Ceraline, J., Limacher, J.-M., Noël, F., Deplanque, G., Duclos, B., Orvain, C., Hajri, A., & Bergerat, J.-P. (n.d.). Effets sur le cycle cellulaire de l’accumulation de p53 dans des fibroblastes humains normaux exposes aux UVc, aux rayons-&ggr; et au cisplatine. Bulletin Du Cancer (French), 83(6), 427–427.