Christophe ORVAIN

IE2 INSERM ; Personne Compétente en Radioactivité

ORCID – ResearcherID

(+33) 03 88 27 53 60

 

 

 

Liste des publications :

 

Miller, J. J., Blanchet, A., Orvain, C., Nouchikian, L., Reviriot, Y., Clarke, R. M., Martelino, D., Wilson, D., Gaiddon, C., & Storr, T. (2019). Bifunctional ligand design for modulating mutant p53 aggregation in cancer. Chemical Science, 10(46), 10802–10814. https://doi.org/10.1039/c9sc04151f
Spaety, M.-E., Gries, A., Badie, A., Venkatasamy, A., Romain, B., Orvain, C., Yanagihara, K., Okamoto, K., Jung, A. C., Mellitzer, G., Pfeffer, S., & Gaiddon, C. (2019). HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers, 11(11), 1747. https://doi.org/10.3390/cancers11111747
Miller, J. J., Orvain, C., Jozi, S., Clarke, R. M., Smith, J. R., Blanchet, A., Gaiddon, C., Warren, J. J., & Storr, T. (2018). Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer. Chemistry (Weinheim an Der Bergstrasse, Germany), 24(67), 17734–17742. https://doi.org/10.1002/chem.201802677
Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., Orvain, C., Hejl, M., Hanif, M., Jakupec, M. A., Keppler, B. K., Gaiddon, C., & Hartinger, C. G. (2018). Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry, 57(5), 2851–2864. https://doi.org/10.1021/acs.inorgchem.7b03210
Khalil, G., Orvain, C., Fang, L., Barloy, L., Chaumont, A., Gaiddon, C., Henry, M., Kyritsakas, N., & Mobian, P. (2016). Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities. Dalton Transactions (Cambridge, England: 2003), 45(47), 19072–19085. https://doi.org/10.1039/c6dt03477b
Nivlet, L., Herrmann, J., Martin, D. E., Meunier, A., Orvain, C., & Gradwohl, G. (2016). Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas. Journal of Molecular Endocrinology, 56(2), 77–90. https://doi.org/10.1530/JME-15-0213
Rico Bautista, H., Saavedra Díaz, R. O., Shen, L. Q., Orvain, C., Gaiddon, C., Le Lagadec, R., & Ryabov, A. D. (2016). Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells. Journal of Inorganic Biochemistry, 163, 28–38. https://doi.org/10.1016/j.jinorgbio.2016.07.014
Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M. L., Mellitzer, G., & Gradwohl, G. (2010). Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England), 137(2), 203–212. https://doi.org/10.1242/dev.041673
Orvain, C., Matre, V., & Gabrielsen, O. S. (2008). The transcription factor c-Myb affects pre-mRNA splicing. Biochemical and Biophysical Research Communications, 372(2), 309–313. https://doi.org/10.1016/j.bbrc.2008.05.054
Martin, M., Hauer, V., Messmer, M., Orvain, C., & Gradwohl, G. (2007). Transcription factors in pancreatic development. Animal models. Endocrine Development, 12, 24–32. https://doi.org/10.1159/000109602
Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P. A., Sander, M., & Gradwohl, G. (2004). Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice. Molecular Endocrinology (Baltimore, Md.), 18(11), 2765–2776. https://doi.org/10.1210/me.2004-0243
Delva, L., Gallais, I., Guillouf, C., Denis, N., Orvain, C., & Moreau-Gachelin, F. (2004). Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells. Oncogene, 23(25), 4389–4399. https://doi.org/10.1038/sj.onc.1207578
Matre, V., Høvring, P. I., Fjeldheim, A.-K., Helgeland, L., Orvain, C., Andersson, K. B., Gautvik, K. M., & Gabrielsen, O. S. (2003). The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb. The Biochemical Journal, 372(Pt 3), 851–859. https://doi.org/10.1042/BJ20030057
Orvain, C., & Gabrielsen, O. (2001). Mise en évidence de l’implication du facteur de transcription c-Myb dans l’épissage des ARNs pre-messagers. Bulletin Scientifique de l’Ambassade de France En Norvege.
Lerga, A., Hallier, M., Delva, L., Orvain, C., Gallais, I., Marie, J., & Moreau-Gachelin, F. (2001). Identification of an RNA binding specificity for the potential splicing factor TLS. The Journal of Biological Chemistry, 276(9), 6807–6816. https://doi.org/10.1074/jbc.M008304200
Céraline, J., Deplanque, G., Duclos, B., Limacher, J. M., Hajri, A., Noel, F., Orvain, C., Frébourg, T., Klein-Soyer, C., & Bergerat, J. P. (1998). Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents. International Journal of Cancer, 75(3), 432–438. https://doi.org/10.1002/(sici)1097-0215(19980130)75:3<432::aid-ijc17>3.0.co;2-a
Klein-Soyer, C., Duhamel-Clérin, E., Ravanat, C., Orvain, C., Lanza, F., & Cazenave, J.-P. (1997). PF4 inhibits thrombin-stimulated MMP-1 and MMP-3 metalloproteinase expression in human vascular endothelial cells. Comptes Rendus de l’Académie Des Sciences - Series III - Sciences de La Vie, 320(11), 857–868. https://doi.org/10.1016/S0764-4469(97)80870-0
Duhamel-Clérin, E., Orvain, C., Lanza, F., Cazenave, J.-P., & Klein-Soyer, C. (1997). Thrombin Receptor-Mediated Increase of Two Matrix Metalloproteinases, MMP-1 and MMP-3, in Human Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(10), 1931–1938. https://doi.org/10.1161/01.ATV.17.10.1931
Klein-Soyer, C., Céraline, J., Orvain, C., de la Salle, C., Bergerat, J. P., & Cazenave, J. P. (1997). Angiogenesis inhibitor SR 25989 upregulates thrombospondin-1 expression in human vascular endothelial cells and foreskin fibroblasts. Biology of the Cell, 89(4), 295–307.
Ceraline, J., Limacher, J.-M., Noël, F., Deplanque, G., Duclos, B., Orvain, C., Hajri, A., & Bergerat, J.-P. (n.d.). Effets sur le cycle cellulaire de l’accumulation de p53 dans des fibroblastes humains normaux exposes aux UVc, aux rayons-&ggr; et au cisplatine. Bulletin Du Cancer (French), 83(6), 427–427.