Dominique GUENOT

Directeur de recherche 2 CNRS

ORCID – Profil LinkedinResearchGateResearcherIDCV

(+33) 03 88 27 53 62

 

 

 

Liste des publications :

 

Fechter, P., Cruz Da Silva, E., Mercier, M.-C., Noulet, F., Etienne-Seloum, N., Guenot, D., … Choulier, L. (2019). RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma. Molecular Therapy. Nucleic Acids, 17, 63–77. https://doi.org/10.1016/j.omtn.2019.05.006
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., … Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Mammadova-Bach, E., Rupp, T., Spenlé, C., Jivkov, I., Shankaranarayanan, P., Klein, A., … Lefebvre, O. (2018). Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biology of the Cell, 110(8), 178–195. https://doi.org/10.1111/boc.201800007
Emprou, C., Le Van Quyen, P., Jégu, J., Prim, N., Weingertner, N., Guérin, E., … Beau-Faller, M. (2018). SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients. Cancer Medicine, 7(7), 3278–3291. https://doi.org/10.1002/cam4.1545
Romain, B., Rohmer, O., Schimchowitsch, S., Hübner, M., Delhorme, J.-B., Brigand, C., … Guenot, D. (2018). Influence of preoperative life satisfaction on recovery and outcomes after colorectal cancer surgery - a prospective pilot study. Health and Quality of Life Outcomes, 16(1), 16. https://doi.org/10.1186/s12955-017-0824-4
Marisa, L., Svrcek, M., Collura, A., Becht, E., Cervera, P., Wanherdrick, K., … Duval, A. (2018). The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors. Journal of the National Cancer Institute, 110(1), 68–77. https://doi.org/10.1093/jnci/djx136
Nguyen, A., Moussallieh, F. M., Mackay, A., Cicek, A. E., Coca, A., Chenard, M. P., … Entz-Werlé, N. (2017). Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition. Oncotarget, 8(42), 71597–71617. https://doi.org/10.18632/oncotarget.16500
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., … Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366. https://doi.org/10.18632/oncotarget.16323
Renaud, S., Schaeffer, M., Falcoz, P.-E., Seitlinger, J., Romain, B., Voegeli, A.-C., … Massard, G. (2017). Perioperative bevacizumab improves survival following lung metastasectomy for colorectal cancer in patients harbouring v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue exon 2 codon 12 mutations†. European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery, 51(2), 255–262. https://doi.org/10.1093/ejcts/ezw304
Farah, I., Nguyen, T. N. Q., Groh, A., Guenot, D., Jeannesson, P., & Gobinet, C. (2016). Development of a memetic clustering algorithm for optimal spectral histology: application to FTIR images of normal human colon. The Analyst, 141(11), 3296–3304. https://doi.org/10.1039/c5an02227d
Nguyen, T. N. Q., Jeannesson, P., Groh, A., Piot, O., Guenot, D., & Gobinet, C. (2016). Fully unsupervised inter-individual IR spectral histology of paraffinized tissue sections of normal colon. Journal of Biophotonics, 9(5), 521–532. https://doi.org/10.1002/jbio.201500285
Renaud, S., Falcoz, P.-E., Romain, B., Olland, A., Santelmo, N., Brigand, C., … Massard, G. (2015). Reply: Comment on “KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colo-rectal cancer.” British Journal of Cancer, 113(11), 1637–1638. https://doi.org/10.1038/bjc.2015.330
Renaud, S., Falcoz, P.-E., Schaëffer, M., Guenot, D., Romain, B., Olland, A., … Massard, G. (2015). Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases. British Journal of Cancer, 113(8), 1206–1215. https://doi.org/10.1038/bjc.2015.327
Weingertner, N., Meyer, N., Voegeli, A.-C., Guenot, D., Renaud, S., Massard, G., … Beau-Faller, M. (2015). Correlation between MET protein expression and MET gene copy number in a Caucasian cohort of non-small cell lung cancers according to the new IASLC/ATS/ERS classification. Pathology, 47(4), 320–328. https://doi.org/10.1097/PAT.0000000000000269
Nguyen, T. N. Q., Jeannesson, P., Groh, A., Guenot, D., & Gobinet, C. (2015). Development of a hierarchical double application of crisp cluster validity indices: a proof-of-concept study for automated FTIR spectral histology. The Analyst, 140(7), 2439–2448. https://doi.org/10.1039/c4an01937g
Renaud, S., Romain, B., Falcoz, P.-E., Olland, A., Santelmo, N., Brigand, C., … Massard, G. (2015). KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. British Journal of Cancer, 112(4), 720–728. https://doi.org/10.1038/bjc.2014.499
Manceau, G., Marisa, L., Boige, V., Duval, A., Gaub, M.-P., Milano, G., … Laurent-Puig, P. (2015). PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer. Cancer Medicine. https://doi.org/10.1002/cam4.370
Spenlé, C., Gasser, I., Saupe, F., Janssen, K.-P., Arnold, C., Klein, A., … Orend, G. (2015). Spatial organization of the tenascin-C microenvironment in experimental and human cancer. Cell Adhesion & Migration, 9(1–2), 4–13. https://doi.org/10.1080/19336918.2015.1005452
Lasthaus, C., Litzler, M., Marcellin, L., Chenard, M.-P., Marec-Bérard, P., Tabone, M.-D., … Entz-Werlé, N. (2015). Molecular Reclassification in Pediatric Osteosarcomas at Surgical Resection is a Potential Helpful Prognostic Marker. Journal of Molecular Biomarkers & Diagnosis, 06(02). https://doi.org/10.4172/2155-9929.1000229
Nguyen, A., Legrain, M., Noel, G., Coca, A., Meyer Ea, N., Schott, R., … Entz-Werle, N. (2015). An Innovative Fluorescent Semi-quantitative Methylation-specific PCR Method for the Determination of MGMT Promoter Methylation is Reflecting Intra-tumor Heterogeneity. Current Cancer Drug Targets, 15(7), 624–640.
Prim, N., Legrain, M., Guerin, E., Mennecier, B., Weingertner, N., Voegeli, A.-C., … Beau-Faller, M. (2014). Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients. European Respiratory Review: An Official Journal of the European Respiratory Society, 23(133), 390–392. https://doi.org/10.1183/09059180.00009313
Romain, B., Meyer, N., Brigand, C., Chenard, M.-P., Schneider, A., & Guenot, D. (2014). Molecular markers for recurrence and sensitivity to preoperative chemoradiotherapy in locally advanced rectal tumours. Digestive Surgery, 31(4–5), 347–353. https://doi.org/10.1159/000368122
Romain, B., Hachet-Haas, M., Rohr, S., Brigand, C., Galzi, J.-L., Gaub, M.-P., … Guenot, D. (2014). Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. Molecular Cancer, 13, 58. https://doi.org/10.1186/1476-4598-13-58
Schmitt, C., Voegelin, M., Marin, A., Schmitt, M., Schegg, F., Hénon, P., … Tarnus, C. (2013). Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorganic & Medicinal Chemistry, 21(7), 2135–2144. https://doi.org/10.1016/j.bmc.2012.12.038
Marisa, L., de Reyniès, A., Duval, A., Selves, J., Gaub, M. P., Vescovo, L., … Boige, V. (2013). Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Medicine, 10(5), e1001453. https://doi.org/10.1371/journal.pmed.1001453
Nguyen, A., Lasthaus, C., Guerin, E., Marcellin, L., Pencreach, E., Gaub, M.-P., … Entz-Werle, N. (2013). Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse. Cancers, 5(2), 662–675. https://doi.org/10.3390/cancers5020662
Cosset, E. C., Godet, J., Entz-Werlé, N., Guérin, E., Guenot, D., Froelich, S., … Martin, S. (2012). Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma. International Journal of Cancer. Journal International Du Cancer, 131(3), 601–611. https://doi.org/10.1002/ijc.26415
Janouskova, H., Maglott, A., Leger, D. Y., Bossert, C., Noulet, F., Guerin, E., … Dontenwill, M. (2012). Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma. Cancer Research, 72(14), 3463–3470. https://doi.org/10.1158/0008-5472.CAN-11-4199
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Guérin, E., Raffelsberger, W., Pencreach, E., Maier, A., Neuville, A., Schneider, A., … Guenot, D. (2012). In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1α target genes and decreases tumor angiogenesis. Molecular Medicine (Cambridge, Mass.), 18, 83–94. https://doi.org/10.2119/molmed.2011.00120
Neuville, A., Nicolet, C., Meyer, N., Schneider, A., Legrain, M., Brigand, C., … Guenot, D. (2011). Histologic characteristics of non-microsatellite-instable colon adenomas correlate with distinct molecular patterns. Human Pathology, 42(2), 244–253. https://doi.org/10.1016/j.humpath.2010.07.003
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., … Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Romain, B., Neuville, A., Meyer, N., Brigand, C., Rohr, S., Schneider, A., … Guenot, D. (2010). Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment. BMC Cancer, 10, 561. https://doi.org/10.1186/1471-2407-10-561
Nicolet, C., Guérin, E., Neuville, A., Kerckaert, J.-P., Wicker, N., Bergmann, E., … Guenot, D. (2009). Evidence for various 20q status using allelotyping, CGH arrays, and quantitative PCR in distal CIN colon cancers. Cancer Letters, 282(2), 195–204. https://doi.org/10.1016/j.canlet.2009.03.012
Pencreach, E., Guérin, E., Nicolet, C., Lelong-Rebel, I., Voegeli, A.-C., Oudet, P., … Guenot, D. (2009). Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 15(4), 1297–1307. https://doi.org/10.1158/1078-0432.CCR-08-0889
Wolthuis, R., Travo, A., Nicolet, C., Neuville, A., Gaub, M.-P., Guenot, D., … Piot, O. (2008). IR spectral imaging for histopathological characterization of xenografted human colon carcinomas. Analytical Chemistry, 80(22), 8461–8469. https://doi.org/10.1021/ac801191x
Weber, J.-C., Meyer, N., Pencreach, E., Schneider, A., Guérin, E., Neuville, A., … Gaub, M.-P. (2007). Allelotyping analyses of synchronous primary and metastasis CIN colon cancers identified different subtypes. International Journal of Cancer. Journal International Du Cancer, 120(3), 524–532. https://doi.org/10.1002/ijc.22343
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., … Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744. https://doi.org/10.2353/ajpath.2007.060696
Guenot, D., Guérin, E., Aguillon-Romain, S., Pencreach, E., Schneider, A., Neuville, A., … Gaub, M.-P. (2006). Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability. The Journal of Pathology, 208(5), 643–652. https://doi.org/10.1002/path.1936
Domon-Dell, C., Schneider, A., Moucadel, V., Guerin, E., Guenot, D., Aguillon, S., … Freund, J.-N. (2003). Cdx1 homeobox gene during human colon cancer progression. Oncogene, 22(39), 7913–7921. https://doi.org/10.1038/sj.onc.1206756