Dominique GUENOT

Directeur de recherche 2 CNRS

ORCID – Profil LinkedinResearchGateResearcherIDCV

(+33) 03 88 27 53 62




Liste des publications :


Pensec, C., Gillaizeau, F., Guenot, D., Bessard, A., Carton, T., Leuillet, S., Campone, M., Neunlist, M., Blottière, H. M., & Le Vacon, F. (2020). Impact of pemetrexed chemotherapy on the gut microbiota and intestinal inflammation of patient-lung-derived tumor xenograft (PDX) mouse models. Scientific Reports, 10(1), 9094.
Blandin, A.-F., Durand, A., Litzler, M., Tripp, A., Guérin, É., Ruhland, E., Obrecht, A., Keime, C., Fuchs, Q., Reita, D., Lhermitte, B., Coca, A., Jones, C., Rebel, I. L., Villa, P., Namer, I. J., Dontenwill, M., Guenot, D., & Entz-Werle, N. (2019). Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity. Cancers, 11(12).
Reita, D., Bour, C., Benbrika, R., Groh, A., Pencreach, E., Guérin, E., & Guenot, D. (2019). Synergistic Anti-Tumor Effect of mTOR Inhibitors with Irinotecan on Colon Cancer Cells. Cancers, 11(10).
Fechter, P., Cruz Da Silva, E., Mercier, M.-C., Noulet, F., Etienne-Seloum, N., Guenot, D., Lehmann, M., Vauchelles, R., Martin, S., Lelong-Rebel, I., Ray, A.-M., Seguin, C., Dontenwill, M., & Choulier, L. (2019). RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma. Molecular Therapy. Nucleic Acids, 17, 63–77.
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155.
Mammadova-Bach, E., Rupp, T., Spenlé, C., Jivkov, I., Shankaranarayanan, P., Klein, A., Pisarsky, L., Méchine-Neuville, A., Cremel, G., Kedinger, M., De Wever, O., Ambartsumian, N., Robine, S., Pencreach, E., Guenot, D., Simon-Assmann, P., Goetz, J. G., Orend, G., & Lefebvre, O. (2018). Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biology of the Cell, 110(8), 178–195.
Emprou, C., Le Van Quyen, P., Jégu, J., Prim, N., Weingertner, N., Guérin, E., Pencreach, E., Legrain, M., Voegeli, A.-C., Leduc, C., Mennecier, B., Falcoz, P.-E., Olland, A., Santelmo, N., Quoix, E., Massard, G., Guenot, D., Chenard, M.-P., & Beau-Faller, M. (2018). SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients. Cancer Medicine, 7(7), 3278–3291.
Romain, B., Rohmer, O., Schimchowitsch, S., Hübner, M., Delhorme, J.-B., Brigand, C., Rohr, S., & Guenot, D. (2018). Influence of preoperative life satisfaction on recovery and outcomes after colorectal cancer surgery - a prospective pilot study. Health and Quality of Life Outcomes, 16(1), 16.
Marisa, L., Svrcek, M., Collura, A., Becht, E., Cervera, P., Wanherdrick, K., Buhard, O., Goloudina, A., Jonchère, V., Selves, J., Milano, G., Guenot, D., Cohen, R., Colas, C., Laurent-Puig, P., Olschwang, S., Lefèvre, J. H., Parc, Y., Boige, V., … Duval, A. (2018). The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors. Journal of the National Cancer Institute, 110(1), 68–77.
Nguyen, A., Moussallieh, F. M., Mackay, A., Cicek, A. E., Coca, A., Chenard, M. P., Weingertner, N., Lhermitte, B., Letouzé, E., Guérin, E., Pencreach, E., Jannier, S., Guenot, D., Namer, I. J., Jones, C., & Entz-Werlé, N. (2017). Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition. Oncotarget, 8(42), 71597–71617.
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., Poidevin, L., Bour, C., Freund, J.-N., Duluc, I., Guenot, D., & Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366.
Renaud, S., Schaeffer, M., Falcoz, P.-E., Seitlinger, J., Romain, B., Voegeli, A.-C., Legrain, M., Reeb, J., Santelmo, N., Rohr, S., Brigand, C., Olland, A., Guenot, D., & Massard, G. (2017). Perioperative bevacizumab improves survival following lung metastasectomy for colorectal cancer in patients harbouring v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue exon 2 codon 12 mutations†. European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery, 51(2), 255–262.
Farah, I., Nguyen, T. N. Q., Groh, A., Guenot, D., Jeannesson, P., & Gobinet, C. (2016). Development of a memetic clustering algorithm for optimal spectral histology: application to FTIR images of normal human colon. The Analyst, 141(11), 3296–3304.
Nguyen, T. N. Q., Jeannesson, P., Groh, A., Piot, O., Guenot, D., & Gobinet, C. (2016). Fully unsupervised inter-individual IR spectral histology of paraffinized tissue sections of normal colon. Journal of Biophotonics, 9(5), 521–532.
Renaud, S., Falcoz, P.-E., Romain, B., Olland, A., Santelmo, N., Brigand, C., Rohr, S., Guenot, D., & Massard, G. (2015). Reply: Comment on “KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colo-rectal cancer.” British Journal of Cancer, 113(11), 1637–1638.
Renaud, S., Falcoz, P.-E., Schaëffer, M., Guenot, D., Romain, B., Olland, A., Reeb, J., Santelmo, N., Chenard, M.-P., Legrain, M., Voegeli, A.-C., Beau-Faller, M., & Massard, G. (2015). Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases. British Journal of Cancer, 113(8), 1206–1215.
Weingertner, N., Meyer, N., Voegeli, A.-C., Guenot, D., Renaud, S., Massard, G., Falcoz, P.-E., Olland, A., Mennecier, B., Gaub, M.-P., Lindner, V., Ghnassia, J.-P., Quoix, E., Chenard, M.-P., & Beau-Faller, M. (2015). Correlation between MET protein expression and MET gene copy number in a Caucasian cohort of non-small cell lung cancers according to the new IASLC/ATS/ERS classification. Pathology, 47(4), 320–328.
Nguyen, T. N. Q., Jeannesson, P., Groh, A., Guenot, D., & Gobinet, C. (2015). Development of a hierarchical double application of crisp cluster validity indices: a proof-of-concept study for automated FTIR spectral histology. The Analyst, 140(7), 2439–2448.
Renaud, S., Romain, B., Falcoz, P.-E., Olland, A., Santelmo, N., Brigand, C., Rohr, S., Guenot, D., & Massard, G. (2015). KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. British Journal of Cancer, 112(4), 720–728.
Manceau, G., Marisa, L., Boige, V., Duval, A., Gaub, M.-P., Milano, G., Selves, J., Olschwang, S., Jooste, V., le Legrain, M., Lecorre, D., Guenot, D., Etienne-Grimaldi, M.-C., Kirzin, S., Martin, L., Lepage, C., Bouvier, A.-M., & Laurent-Puig, P. (2015). PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer. Cancer Medicine.
Spenlé, C., Gasser, I., Saupe, F., Janssen, K.-P., Arnold, C., Klein, A., van der Heyden, M., Mutterer, J., Neuville-Méchine, A., Chenard, M.-P., Guenot, D., Esposito, I., Slotta-Huspenina, J., Ambartsumian, N., Simon-Assmann, P., & Orend, G. (2015). Spatial organization of the tenascin-C microenvironment in experimental and human cancer. Cell Adhesion & Migration, 9(1–2), 4–13.
Lasthaus, C., Litzler, M., Marcellin, L., Chenard, M.-P., Marec-Bérard, P., Tabone, M.-D., Pacquement, H., Brugieres, L., Guenot, D., & Entz-Werlé, N. (2015). Molecular Reclassification in Pediatric Osteosarcomas at Surgical Resection is a Potential Helpful Prognostic Marker. Journal of Molecular Biomarkers & Diagnosis, 06(02).
Nguyen, A., Legrain, M., Noel, G., Coca, A., Meyer Ea, N., Schott, R., Lasthaus, C., Chenard, M. P., Gaub, M. P., Lessinger, J. M., Guenot, D., & Entz-Werle, N. (2015). An Innovative Fluorescent Semi-quantitative Methylation-specific PCR Method for the Determination of MGMT Promoter Methylation is Reflecting Intra-tumor Heterogeneity. Current Cancer Drug Targets, 15(7), 624–640.
Prim, N., Legrain, M., Guerin, E., Mennecier, B., Weingertner, N., Voegeli, A.-C., Guenot, D., Maugard, C. M., Quoix, A.-E., & Beau-Faller, M. (2014). Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients. European Respiratory Review: An Official Journal of the European Respiratory Society, 23(133), 390–392.
Romain, B., Meyer, N., Brigand, C., Chenard, M.-P., Schneider, A., & Guenot, D. (2014). Molecular markers for recurrence and sensitivity to preoperative chemoradiotherapy in locally advanced rectal tumours. Digestive Surgery, 31(4–5), 347–353.
Romain, B., Hachet-Haas, M., Rohr, S., Brigand, C., Galzi, J.-L., Gaub, M.-P., Pencreach, E., & Guenot, D. (2014). Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. Molecular Cancer, 13, 58.
Schmitt, C., Voegelin, M., Marin, A., Schmitt, M., Schegg, F., Hénon, P., Guenot, D., & Tarnus, C. (2013). Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorganic & Medicinal Chemistry, 21(7), 2135–2144.
Marisa, L., de Reyniès, A., Duval, A., Selves, J., Gaub, M. P., Vescovo, L., Etienne-Grimaldi, M.-C., Schiappa, R., Guenot, D., Ayadi, M., Kirzin, S., Chazal, M., Fléjou, J.-F., Benchimol, D., Berger, A., Lagarde, A., Pencreach, E., Piard, F., Elias, D., … Boige, V. (2013). Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Medicine, 10(5), e1001453.
Nguyen, A., Lasthaus, C., Guerin, E., Marcellin, L., Pencreach, E., Gaub, M.-P., Guenot, D., & Entz-Werle, N. (2013). Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse. Cancers, 5(2), 662–675.
Cosset, E. C., Godet, J., Entz-Werlé, N., Guérin, E., Guenot, D., Froelich, S., Bonnet, D., Pinel, S., Plenat, F., Chastagner, P., Dontenwill, M., & Martin, S. (2012). Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma. International Journal of Cancer. Journal International Du Cancer, 131(3), 601–611.
Janouskova, H., Maglott, A., Leger, D. Y., Bossert, C., Noulet, F., Guerin, E., Guenot, D., Pinel, S., Chastagner, P., Plenat, F., Entz-Werle, N., Lehmann-Che, J., Godet, J., Martin, S., Teisinger, J., & Dontenwill, M. (2012). Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma. Cancer Research, 72(14), 3463–3470.
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3.
Guérin, E., Raffelsberger, W., Pencreach, E., Maier, A., Neuville, A., Schneider, A., Bachellier, P., Rohr, S., Petitprez, A., Poch, O., Moras, D., Oudet, P., Larsen, A. K., Gaub, M.-P., & Guenot, D. (2012). In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1α target genes and decreases tumor angiogenesis. Molecular Medicine (Cambridge, Mass.), 18, 83–94.
Neuville, A., Nicolet, C., Meyer, N., Schneider, A., Legrain, M., Brigand, C., Duclos, B., Bachellier, P., Oudet, P., Bellocq, J.-P., Kedinger, M., Gaub, M.-P., & Guenot, D. (2011). Histologic characteristics of non-microsatellite-instable colon adenomas correlate with distinct molecular patterns. Human Pathology, 42(2), 244–253.
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., Simo-Noumbissie, P., Guérin, E., Gaub, M.-P., Freund, J.-N., Boehm, N., Constantinesco, A., Lutz, P., Guenot, D., & Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Romain, B., Neuville, A., Meyer, N., Brigand, C., Rohr, S., Schneider, A., Gaub, M.-P., & Guenot, D. (2010). Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment. BMC Cancer, 10, 561.
Nicolet, C., Guérin, E., Neuville, A., Kerckaert, J.-P., Wicker, N., Bergmann, E., Brigand, C., Kedinger, M., Gaub, M.-P., & Guenot, D. (2009). Evidence for various 20q status using allelotyping, CGH arrays, and quantitative PCR in distal CIN colon cancers. Cancer Letters, 282(2), 195–204.
Pencreach, E., Guérin, E., Nicolet, C., Lelong-Rebel, I., Voegeli, A.-C., Oudet, P., Larsen, A. K., Gaub, M.-P., & Guenot, D. (2009). Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 15(4), 1297–1307.
Wolthuis, R., Travo, A., Nicolet, C., Neuville, A., Gaub, M.-P., Guenot, D., Ly, E., Manfait, M., Jeannesson, P., & Piot, O. (2008). IR spectral imaging for histopathological characterization of xenografted human colon carcinomas. Analytical Chemistry, 80(22), 8461–8469.
Weber, J.-C., Meyer, N., Pencreach, E., Schneider, A., Guérin, E., Neuville, A., Stemmer, C., Brigand, C., Bachellier, P., Rohr, S., Kedinger, M., Meyer, C., Guenot, D., Oudet, P., Jaeck, D., & Gaub, M.-P. (2007). Allelotyping analyses of synchronous primary and metastasis CIN colon cancers identified different subtypes. International Journal of Cancer. Journal International Du Cancer, 120(3), 524–532.
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., Brabletz, T., Kedinger, M., Freund, J.-N., & Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744.
Guenot, D., Guérin, E., Aguillon-Romain, S., Pencreach, E., Schneider, A., Neuville, A., Chenard, M.-P., Duluc, I., Du Manoir, S., Brigand, C., Oudet, P., Kedinger, M., & Gaub, M.-P. (2006). Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability. The Journal of Pathology, 208(5), 643–652.
Domon-Dell, C., Schneider, A., Moucadel, V., Guerin, E., Guenot, D., Aguillon, S., Duluc, I., Martin, E., Iovanna, J., Launay, J.-F., Duclos, B., Chenard, M.-P., Meyer, C., Oudet, P., Kedinger, M., Gaub, M.-P., & Freund, J.-N. (2003). Cdx1 homeobox gene during human colon cancer progression. Oncogene, 22(39), 7913–7921.