Georg MELLITZER

CR INSERM ; Sauveteur Secouriste du Travail

ORCID – ResearcherID

(+33) 03 88 27 53 67

Liste des publications :

Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., … Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Licona, C., Spaety, M.-E., Capuozzo, A., Ali, M., Santamaria, R., Armant, O., … Gaiddon, C. (2017). A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8(2), 2568–2584. https://doi.org/10.18632/oncotarget.13711
Chow, M. J., Licona, C., Pastorin, G., Mellitzer, G., Ang, W. H., & Gaiddon, C. (2016). Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance. Chemical Science, 7(7), 4117–4124. https://doi.org/10.1039/c6sc00268d
von Grabowiecki, Y., Abreu, P., Blanchard, O., Palamiuc, L., Benosman, S., Mériaux, S., … Gaiddon, C. (2016). Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63. ELife, 5, e10528. https://doi.org/10.7554/eLife.10528
von Grabowiecki, Y., Licona, C., Palamiuc, L., Abreu, P., Vidimar, V., Coowar, D., … Gaiddon, C. (2015). Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy. The Journal of Pharmacology and Experimental Therapeutics, 352(1), 23–32. https://doi.org/10.1124/jpet.114.216879
Klajner, M., Licona, C., Fetzer, L., Hebraud, P., Mellitzer, G., Pfeffer, M., … Gaiddon, C. (2014). Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters. Inorganic Chemistry, 53(10), 5150–5158. https://doi.org/10.1021/ic500250e
Anthwal, N., Pelling, M., Claxton, S., Mellitzer, G., Collin, C., Kessaris, N., … Ang, S.-L. (2013). Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Disease Models & Mechanisms, 6(5), 1133–1145. https://doi.org/10.1242/dmm.011916
Vidimar, V., Meng, X., Klajner, M., Licona, C., Fetzer, L., Harlepp, S., … Gaiddon, C. (2012). Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochemical Pharmacology, 84(11), 1428–1436. https://doi.org/10.1016/j.bcp.2012.08.022
Benosman, S., Meng, X., Von Grabowiecki, Y., Palamiuc, L., Hritcu, L., Gross, I., … Gaiddon, C. (2011). Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. The Journal of Biological Chemistry, 286(50), 43013–43025. https://doi.org/10.1074/jbc.M111.261271
Mellitzer, G., & Gradwohl, G. (2011). Enteroendocrine cells and lipid absorption. Current Opinion in Lipidology, 22(3), 171–175. https://doi.org/10.1097/MOL.0b013e32834622a2
Gerbe, F., van Es, J. H., Makrini, L., Brulin, B., Mellitzer, G., Robine, S., … Jay, P. (2011). Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. The Journal of Cell Biology, 192(5), 767–780. https://doi.org/10.1083/jcb.201010127
Mellitzer, G., Beucher, A., Lobstein, V., Michel, P., Robine, S., Kedinger, M., & Gradwohl, G. (2010). Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. The Journal of Clinical Investigation, 120(5), 1708–1721. https://doi.org/10.1172/JCI40794
Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., … Gradwohl, G. (2010). Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England), 137(2), 203–212. https://doi.org/10.1242/dev.041673
Xu, X., D’Hoker, J., Stangé, G., Bonné, S., De Leu, N., Xiao, X., … Heimberg, H. (2008). Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell, 132(2), 197–207. https://doi.org/10.1016/j.cell.2007.12.015
Quayum, N., Kutchma, A., Sarkar, S. A., Juhl, K., Gradwohl, G., Mellitzer, G., … Jensen, J. (2008). GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist. Experimental Diabetes Research, 2008, 312060. https://doi.org/10.1155/2008/312060
Mellitzer, G., Bonné, S., Luco, R. F., Van De Casteele, M., Lenne-Samuel, N., Collombat, P., … Heimberg, H. (2006). IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. The EMBO Journal, 25(6), 1344–1352. https://doi.org/10.1038/sj.emboj.7601011
Heller, R. S., Jenny, M., Collombat, P., Mansouri, A., Tomasetto, C., Madsen, O. D., … Serup, P. (2005). Genetic determinants of pancreatic epsilon-cell development. Developmental Biology, 286(1), 217–224. https://doi.org/10.1016/j.ydbio.2005.06.041
Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P. A., … Gradwohl, G. (2004). Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice. Molecular Endocrinology (Baltimore, Md.), 18(11), 2765–2776. https://doi.org/10.1210/me.2004-0243
Mellitzer, G., Hallonet, M., Chen, L., & Ang, S.-L. (2002). Spatial and temporal “knock down” of gene expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos. Mechanisms of Development, 118(1–2), 57–63.
Xu, Q., Mellitzer, G., & Wilkinson, D. G. (2000). Roles of Eph receptors and ephrins in segmental patterning. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 355(1399), 993–1002. https://doi.org/10.1098/rstb.2000.0635
Mellitzer, G., Xu, Q., & Wilkinson, D. G. (2000). Control of cell behaviour by signalling through Eph receptors and ephrins. Current Opinion in Neurobiology, 10(3), 400–408.
von Lindern, M., Zauner, W., Mellitzer, G., Steinlein, P., Fritsch, G., Huber, K., … Beug, H. (1999). The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood, 94(2), 550–559.
Mellitzer, G., Xu, Q., & Wilkinson, D. G. (1999). Eph receptors and ephrins restrict cell intermingling and communication. Nature, 400(6739), 77–81. https://doi.org/10.1038/21907
Xu, Q., Mellitzer, G., Robinson, V., & Wilkinson, D. G. (1999). In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature, 399(6733), 267–271. https://doi.org/10.1038/20452
Wessely, O., Bauer, A., Quang, C. T., Deiner, E. M., von Lindern, M., Mellitzer, G., … Beug, H. (1999). A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor. Biological Chemistry, 380(2), 187–202. https://doi.org/10.1515/BC.1999.027
Wessely, O., Deiner, E. M., Lim, K. C., Mellitzer, G., Steinlein, P., & Beug, H. (1998). Mammalian granulocyte-macrophage colony-stimulating factor receptor expressed in primary avian hematopoietic progenitors: lineage-specific regulation of proliferation and differentiation. The Journal of Cell Biology, 141(4), 1041–1051.
Woldman, I., Mellitzer, G., Kieslinger, M., Buchhart, D., Meinke, A., Beug, H., & Decker, T. (1997). STAT5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor. Journal of Immunology (Baltimore, Md.: 1950), 159(2), 877–886.
Wessely, O., Mellitzer, G., von Lindern, M., Levitzki, A., Gazit, A., Ischenko, I., … Beug, H. (1997). Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research, 8(5), 481–493.
Beug, H., Bauer, A., Dolznig, H., von Lindern, M., Lobmayer, L., Mellitzer, G., … Mullner, E. (1996). Avian erythropoiesis and erythroleukemia: towards understanding the role of the biomolecules involved. Biochimica Et Biophysica Acta, 1288(3), M35-47.
Mellitzer, G., Wessely, O., Decker, T., Meinke, A., Hayman, M. J., & Beug, H. (1996). Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9600–9605.
Boehmelt, G., Ulrich, E., Kurzbauer, R., Mellitzer, G., Bird, A., & Zenke, M. (1994). Structure and expression of the chicken retinoblastoma gene. Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research, 5(2), 221–230.
Boehmelt, G., Walker, A., Kabrun, N., Mellitzer, G., Beug, H., Zenke, M., & Enrietto, P. J. (1992). Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression. The EMBO Journal, 11(12), 4641–4652.