CR INSERM ; Sauveteur Secouriste du Travail

ORCID – ResearcherID

(+33) 03 88 27 53 67

Liste des publications :

Beck, M., Baranger, M., Moufok-Sadoun, A., Bersuder, E., Hinkel, I., Mellitzer, G., Martin, E., Marisa, L., Duluc, I., de Reynies, A., Gaiddon, C., Freund, J.-N., & Gross, I. (2020). The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Oncogene.
Licona, C., Delhorme, J.-B., Riegel, G., Vidimar, V., Cerón-Camacho, R., Boff, B., Venkatasamy, A., Tomasetto, C., da Silva Figueiredo Celestino Gomes, P., Rognan, D., Freund, J.-N., Le Lagadec, R., Pfeffer, M., Gross, I., Mellitzer, G., & Gaiddon, C. (2020). Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms. Inorganic Chemistry Frontiers, 7(3), 678–688.
Spaety, M.-E., Gries, A., Badie, A., Venkatasamy, A., Romain, B., Orvain, C., Yanagihara, K., Okamoto, K., Jung, A. C., Mellitzer, G., Pfeffer, S., & Gaiddon, C. (2019). HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers, 11(11), 1747.
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155.
Licona, C., Spaety, M.-E., Capuozzo, A., Ali, M., Santamaria, R., Armant, O., Delalande, F., Van Dorsselaer, A., Cianferani, S., Spencer, J., Pfeffer, M., Mellitzer, G., & Gaiddon, C. (2017). A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8(2), 2568–2584.
Chow, M. J., Licona, C., Pastorin, G., Mellitzer, G., Ang, W. H., & Gaiddon, C. (2016). Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance. Chemical Science, 7(7), 4117–4124.
von Grabowiecki, Y., Abreu, P., Blanchard, O., Palamiuc, L., Benosman, S., Mériaux, S., Devignot, V., Gross, I., Mellitzer, G., Gonzalez de Aguilar, J. L., & Gaiddon, C. (2016). Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63. ELife, 5, e10528.
von Grabowiecki, Y., Licona, C., Palamiuc, L., Abreu, P., Vidimar, V., Coowar, D., Mellitzer, G., & Gaiddon, C. (2015). Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy. The Journal of Pharmacology and Experimental Therapeutics, 352(1), 23–32.
Klajner, M., Licona, C., Fetzer, L., Hebraud, P., Mellitzer, G., Pfeffer, M., Harlepp, S., & Gaiddon, C. (2014). Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters. Inorganic Chemistry, 53(10), 5150–5158.
Anthwal, N., Pelling, M., Claxton, S., Mellitzer, G., Collin, C., Kessaris, N., Richardson, W. D., Gradwohl, G., & Ang, S.-L. (2013). Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Disease Models & Mechanisms, 6(5), 1133–1145.
Vidimar, V., Meng, X., Klajner, M., Licona, C., Fetzer, L., Harlepp, S., Hébraud, P., Sidhoum, M., Sirlin, C., Loeffler, J.-P., Mellitzer, G., Sava, G., Pfeffer, M., & Gaiddon, C. (2012). Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochemical Pharmacology, 84(11), 1428–1436.
Benosman, S., Meng, X., Von Grabowiecki, Y., Palamiuc, L., Hritcu, L., Gross, I., Mellitzer, G., Taya, Y., Loeffler, J.-P., & Gaiddon, C. (2011). Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. The Journal of Biological Chemistry, 286(50), 43013–43025.
Mellitzer, G., & Gradwohl, G. (2011). Enteroendocrine cells and lipid absorption. Current Opinion in Lipidology, 22(3), 171–175.
Gerbe, F., van Es, J. H., Makrini, L., Brulin, B., Mellitzer, G., Robine, S., Romagnolo, B., Shroyer, N. F., Bourgaux, J.-F., Pignodel, C., Clevers, H., & Jay, P. (2011). Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. The Journal of Cell Biology, 192(5), 767–780.
Mellitzer, G., Beucher, A., Lobstein, V., Michel, P., Robine, S., Kedinger, M., & Gradwohl, G. (2010). Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. The Journal of Clinical Investigation, 120(5), 1708–1721.
Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M. L., Mellitzer, G., & Gradwohl, G. (2010). Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England), 137(2), 203–212.
Xu, X., D’Hoker, J., Stangé, G., Bonné, S., De Leu, N., Xiao, X., Van de Casteele, M., Mellitzer, G., Ling, Z., Pipeleers, D., Bouwens, L., Scharfmann, R., Gradwohl, G., & Heimberg, H. (2008). Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell, 132(2), 197–207.
Quayum, N., Kutchma, A., Sarkar, S. A., Juhl, K., Gradwohl, G., Mellitzer, G., Hutton, J. C., & Jensen, J. (2008). GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist. Experimental Diabetes Research, 2008, 312060.
Mellitzer, G., Bonné, S., Luco, R. F., Van De Casteele, M., Lenne-Samuel, N., Collombat, P., Mansouri, A., Lee, J., Lan, M., Pipeleers, D., Nielsen, F. C., Ferrer, J., Gradwohl, G., & Heimberg, H. (2006). IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. The EMBO Journal, 25(6), 1344–1352.
Heller, R. S., Jenny, M., Collombat, P., Mansouri, A., Tomasetto, C., Madsen, O. D., Mellitzer, G., Gradwohl, G., & Serup, P. (2005). Genetic determinants of pancreatic epsilon-cell development. Developmental Biology, 286(1), 217–224.
Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P. A., Sander, M., & Gradwohl, G. (2004). Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice. Molecular Endocrinology (Baltimore, Md.), 18(11), 2765–2776.
Mellitzer, G., Hallonet, M., Chen, L., & Ang, S.-L. (2002). Spatial and temporal “knock down” of gene expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos. Mechanisms of Development, 118(1–2), 57–63.
Xu, Q., Mellitzer, G., & Wilkinson, D. G. (2000). Roles of Eph receptors and ephrins in segmental patterning. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 355(1399), 993–1002.
Mellitzer, G., Xu, Q., & Wilkinson, D. G. (2000). Control of cell behaviour by signalling through Eph receptors and ephrins. Current Opinion in Neurobiology, 10(3), 400–408.
von Lindern, M., Zauner, W., Mellitzer, G., Steinlein, P., Fritsch, G., Huber, K., Löwenberg, B., & Beug, H. (1999). The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood, 94(2), 550–559.
Mellitzer, G., Xu, Q., & Wilkinson, D. G. (1999). Eph receptors and ephrins restrict cell intermingling and communication. Nature, 400(6739), 77–81.
Xu, Q., Mellitzer, G., Robinson, V., & Wilkinson, D. G. (1999). In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature, 399(6733), 267–271.
Wessely, O., Bauer, A., Quang, C. T., Deiner, E. M., von Lindern, M., Mellitzer, G., Steinlein, P., Ghysdael, J., & Beug, H. (1999). A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor. Biological Chemistry, 380(2), 187–202.
Wessely, O., Deiner, E. M., Lim, K. C., Mellitzer, G., Steinlein, P., & Beug, H. (1998). Mammalian granulocyte-macrophage colony-stimulating factor receptor expressed in primary avian hematopoietic progenitors: lineage-specific regulation of proliferation and differentiation. The Journal of Cell Biology, 141(4), 1041–1051.
Woldman, I., Mellitzer, G., Kieslinger, M., Buchhart, D., Meinke, A., Beug, H., & Decker, T. (1997). STAT5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor. Journal of Immunology (Baltimore, Md.: 1950), 159(2), 877–886.
Wessely, O., Mellitzer, G., von Lindern, M., Levitzki, A., Gazit, A., Ischenko, I., Hayman, M. J., & Beug, H. (1997). Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research, 8(5), 481–493.
Beug, H., Bauer, A., Dolznig, H., von Lindern, M., Lobmayer, L., Mellitzer, G., Steinlein, P., Wessely, O., & Mullner, E. (1996). Avian erythropoiesis and erythroleukemia: towards understanding the role of the biomolecules involved. Biochimica Et Biophysica Acta, 1288(3), M35-47.
Mellitzer, G., Wessely, O., Decker, T., Meinke, A., Hayman, M. J., & Beug, H. (1996). Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9600–9605.
Boehmelt, G., Ulrich, E., Kurzbauer, R., Mellitzer, G., Bird, A., & Zenke, M. (1994). Structure and expression of the chicken retinoblastoma gene. Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research, 5(2), 221–230.
Boehmelt, G., Walker, A., Kabrun, N., Mellitzer, G., Beug, H., Zenke, M., & Enrietto, P. J. (1992). Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression. The EMBO Journal, 11(12), 4641–4652.