Manuela TAVIAN

Senior Scientist Inserm


(+33) 03 88 27 53 61




Liste des publications :


Julien, E., Biasch, K., El Omar, R., Freund, J.-N., Gachet, C., Lanza, F., & Tavian, M. (2021). Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells. Stem Cells (Dayton, Ohio), 39(5), 636–649.
El Omar, R., Julien, E., Biasch, K., Guffroy, B., Lioure, B., Vallat, L., Gross, I., Domon-Dell, C., Lanza, F., Gachet, C., Negroni, M., Freund, J.-N., & Tavian, M. (2021). CDX2 regulates ACE expression in blood development and leukemia cells. Blood Advances, 5(7), 2012–2016.
Julien, E., El Omar, R., & Tavian, M. (2016). Origin of the hematopoietic system in the human embryo. FEBS Letters, 590(22), 3987–4001.
Travnickova, J., Tran Chau, V., Julien, E., Mateos-Langerak, J., Gonzalez, C., Lelièvre, E., Lutfalla, G., Tavian, M., & Kissa, K. (2015). Primitive macrophages control HSPC mobilization and definitive haematopoiesis. Nature Communications, 6, 6227.
Sinka, L., Biasch, K., Khazaal, I., Péault, B., & Tavian, M. (2012). Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo. Blood, 119(16), 3712–3723.
Mizuochi, C., Fraser, S. T., Biasch, K., Horio, Y., Kikushige, Y., Tani, K., Akashi, K., Tavian, M., & Sugiyama, D. (2012). Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis. PloS One, 7(4), e35763.
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., Gross, I., Rowland, J., Kim, S., & Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727.
Tavian, M., Biasch, K., Sinka, L., Vallet, J., & Péault, B. (2010). Embryonic origin of human hematopoiesis. The International Journal of Developmental Biology, 54(6–7), 1061–1065.
Pomp, O., Brokhman, I., Ziegler, L., Almog, M., Korngreen, A., Tavian, M., & Goldstein, R. S. (2008). PA6-induced human embryonic stem cell-derived neurospheres: a new source of human peripheral sensory neurons and neural crest cells. Brain Research, 1230, 50–60.
Jokubaitis, V. J., Sinka, L., Driessen, R., Whitty, G., Haylock, D. N., Bertoncello, I., Smith, I., Péault, B., Tavian, M., & Simmons, P. J. (2008). Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Blood, 111(8), 4055–4063.
Zambidis, E. T., Sinka, L., Tavian, M., Jokubaitis, V., Park, T. S., Simmons, P., & Péault, B. (2007). Emergence of human angiohematopoietic cells in normal development and from cultured embryonic stem cells. Annals of the New York Academy of Sciences, 1106, 223–232.
Yokota, T., Huang, J., Tavian, M., Nagai, Y., Hirose, J., Zúñiga-Pflücker, J.-C., Péault, B., & Kincade, P. W. (2006). Tracing the first waves of lymphopoiesis in mice. Development (Cambridge, England), 133(10), 2041–2051.
Zambidis, E. T., Oberlin, E., Tavian, M., & Péault, B. (2006). Blood-forming endothelium in human ontogeny: lessons from in utero development and embryonic stem cell culture. Trends in Cardiovascular Medicine, 16(3), 95–101.
Tavian, M., & Péault, B. (2005). The changing cellular environments of hematopoiesis in human development in utero. Experimental Hematology, 33(9), 1062–1069.
Sabatini, F., Petecchia, L., Tavian, M., Jodon de Villeroché, V., Rossi, G. A., & Brouty-Boyé, D. (2005). Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Laboratory Investigation; a Journal of Technical Methods and Pathology, 85(8), 962–971.
Tavian, M., Zheng, B., Oberlin, E., Crisan, M., Sun, B., Huard, J., & Peault, B. (2005). The vascular wall as a source of stem cells. Annals of the New York Academy of Sciences, 1044, 41–50.
Dando, J. S., Tavian, M., Catelain, C., Poirault, S., Bennaceur-Griscelli, A., Sainteny, F., Vainchenker, W., Péault, B., & Lauret, E. (2005). Notch/Delta4 interaction in human embryonic liver CD34+ CD38- cells: positive influence on BFU-E production and LTC-IC potential maintenance. Stem Cells (Dayton, Ohio), 23(4), 550–560.
Tavian, M., & Péault, B. (2005). Analysis of hematopoietic development during human embryonic ontogenesis. Methods in Molecular Medicine, 105, 413–424.
Tavian, M., & Péault, B. (2005). Embryonic development of the human hematopoietic system. The International Journal of Developmental Biology, 49(2–3), 243–250.
Samson, S. I., Richard, O., Tavian, M., Ranson, T., Vosshenrich, C. A. J., Colucci, F., Buer, J., Grosveld, F., Godin, I., & Di Santo, J. P. (2003). GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NK cells. Immunity, 19(5), 701–711.
Peault, B., & Tavian, M. (2003). Hematopoietic stem cell emergence in the human embryo and fetus. Annals of the New York Academy of Sciences, 996, 132–140.
Péault, B., Oberlin, E., & Tavian, M. (2002). Emergence of hematopoietic stem cells in the human embryo. Comptes Rendus Biologies, 325(10), 1021–1026.
Oberlin, E., Tavian, M., Blazsek, I., & Péault, B. (2002). Blood-forming potential of vascular endothelium in the human embryo. Development (Cambridge, England), 129(17), 4147–4157.
Tavian, M., Robin, C., Coulombel, L., & Péault, B. (2001). The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. Immunity, 15(3), 487–495.
Tavian, M., Cortés, F., Robin, C., Schiavon, V., Hallais, M. F., Coulombel, L., Charbord, P., Labastie, M. C., & Péault, B. (2000). [The hemangioblast, common precursor of endothelial and hematopoietic cells]. Transfusion Clinique Et Biologique: Journal De La Societe Francaise De Transfusion Sanguine, 7(3), 238–241.
Watt, S. M., Butler, L. H., Tavian, M., Bühring, H. J., Rappold, I., Simmons, P. J., Zannettino, A. C., Buck, D., Fuchs, A., Doyonnas, R., Chan, J. Y., Levesque, J. P., Peault, B., & Roxanis, I. (2000). Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues. Blood, 95(10), 3113–3124.
Corbeil, D., Röper, K., Hellwig, A., Tavian, M., Miraglia, S., Watt, S. M., Simmons, P. J., Peault, B., Buck, D. W., & Huttner, W. B. (2000). The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions. The Journal of Biological Chemistry, 275(8), 5512–5520.
Tavian, M., Cortés, F., Charbord, P., Labastie, M. C., & Péault, B. (1999). Emergence of the haematopoietic system in the human embryo and foetus. Haematologica, 84 Suppl EHA-4, 1–3.
Aiuti, A., Tavian, M., Cipponi, A., Ficara, F., Zappone, E., Hoxie, J., Peault, B., & Bordignon, C. (1999). Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. European Journal of Immunology, 29(6), 1823–1831.<1823::AID-IMMU1823>3.0.CO;2-B
Tavian, M., Hallais, M. F., & Péault, B. (1999). Emergence of intraembryonic hematopoietic precursors in the pre-liver human embryo. Development (Cambridge, England), 126(4), 793–803.
Aiuti, A., Tavian, M., Cipponi, A., Ficara, F., Zappone, E., Hoxie, J., Peault, B., & Bordignon, C. (1999). Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. European Journal of Immunology, 29(6), 1823–1831.<1823::AID-IMMU1823>3.0.CO;2-B
Karagogeos, D., Pourquié, C., Kyriakopoulou, K., Tavian, M., Stallcup, W., Péault, B., & Pourquié, O. (1997). Expression of the cell adhesion proteins BEN/SC1/DM-GRASP and TAG-1 defines early steps of axonogenesis in the human spinal cord. The Journal of Comparative Neurology, 379(3), 415–427.
Charbord, P., Tavian, M., Humeau, L., & Péault, B. (1996). Early ontogeny of the human marrow from long bones: an immunohistochemical study of hematopoiesis and its microenvironment. Blood, 87(10), 4109–4119.
Tavian, M., Coulombel, L., Luton, D., Clemente, H. S., Dieterlen-Lièvre, F., & Péault, B. (1996). Aorta-associated CD34+ hematopoietic cells in the early human embryo. Blood, 87(1), 67–72.
Charbord, P., Tavian, M., Coulombel, L., Luton, D., San Clemente, H., Humeau, L., Dieterlen-Lièvre, F., & Péault, B. (1995). [Early ontogeny of the human hematopoietic system]. Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales, 189(4), 601–609.
TAVIAN, M., CHARBORD, P., Humeau, L., Luton, D., Dieterlen-Lièvre, F., & Peault, B. (1995). Embryonic and fetal development of the human hematopoietic system in the yolk sac, dorsal aorta, liver and bone marrow. Aplastic anemia, 37–42.
Boiocchi, M., Franceschi, S., Serraino, D., Guarneri, S., Tavian, M., & Diodato, S. (1993). Persistent lack of human immunodeficiency virus infection in intravenous drug users at very high risk. Journal of Acquired Immune Deficiency Syndromes, 6(6), 633–635.
Boiocchi, M., De Re, V., Dolcetti, R., Volpe, R., Gloghini, A., Tavian, M., Viel, A., Maestro, R., & Carbone, A. (1990). Pathogenesis of malignant lymphomas in intravenous drug-abuser, HIV-infected patients. Cancer Detection and Prevention, 14(6), 661–668.
Carbone, A., De Re, V., Gloghini, A., Volpe, R., Tavian, M., Tirelli, U., Monfardini, S., & Boiocchi, M. (1989). Immunoglobulin and T cell receptor gene rearrangements and in situ immunophenotyping in lymphoproliferative disorders. Virchows Archiv. A, Pathological Anatomy and Histopathology, 414(3), 223–230.
Dolcetti, R., De Re, V., Viel, A., Pistello, M., Tavian, M., & Boiocchi, M. (1988). Nuclear oncogene amplification or rearrangement is not involved in human colorectal malignancies. European Journal of Cancer & Clinical Oncology, 24(8), 1321–1328.