Isabelle DULUC

CR INSERM ; Responsable déléguée animalerie ; Correspondante formation ; Sauveteuse Secouriste du Travail

ORCIDResearcherID

(+33) 03 88 27 53 65

Liste des publications :

Rabineau, M., Flick, F., Ehlinger, C., Mathieu, E., Duluc, I., Jung, M., … Vautier, D. (2018). Chromatin de-condensation by switching substrate elasticity. Scientific Reports, 8(1), 12655. https://doi.org/10.1038/s41598-018-31023-2
Balbinot, C., Armant, O., Elarouci, N., Marisa, L., Martin, E., De Clara, E., … Duluc, I. (2018). The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. The Journal of Experimental Medicine, 215(3), 911–926. https://doi.org/10.1084/jem.20170934
Balbinot, C., Vanier, M., Armant, O., Nair, A., Penichon, J., Soret, C., … Freund, J.-N. (2017). Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death and Differentiation, 24(12), 2173–2186. https://doi.org/10.1038/cdd.2017.140
Dillenseger, J.-P., Goetz, C., Sayeh, A., Healy, C., Duluc, I., Freund, J.-N., … Choquet, P. (2017). Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. Journal of Medical Imaging (Bellingham, Wash.), 4(3), 035503. https://doi.org/10.1117/1.JMI.4.3.035503
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., … Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366. https://doi.org/10.18632/oncotarget.16323
Soret, C., Martin, E., Duluc, I., Dantzer, F., Vanier, M., Gross, I., … Domon-Dell, C. (2016). Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Letters, 374(2), 208–215. https://doi.org/10.1016/j.canlet.2016.02.026
Freund, J.-N., Duluc, I., Reimund, J.-M., Gross, I., & Domon-Dell, C. (2015). Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World Journal of Gastroenterology, 21(5), 1436–1443. https://doi.org/10.3748/wjg.v21.i5.1436
Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.-N., Duluc, I., … Léon, C. (2015). Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage. Journal of Thrombosis and Haemostasis: JTH, 13(1), 115–125. https://doi.org/10.1111/jth.12784
Martianov, I., Cler, E., Duluc, I., Vicaire, S., Philipps, M., Freund, J.-N., & Davidson, I. (2014). TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PloS One, 9(2), e87365. https://doi.org/10.1371/journal.pone.0087365
Bellis, J., Duluc, I., Freund, J.-N., & De Mey, J. R. (2013). Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum. Bio-Protocol, 3(20), e942. Retrieved from www.bio-protocol.org/e942
Derbal-Wolfrom, L., Pencreach, E., Saandi, T., Aprahamian, M., Martin, E., Greferath, R., … Freund, J.-N. (2013). Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. Oncogene, 32(36), 4313–4318. https://doi.org/10.1038/onc.2012.445
Saandi, T., Baraille, F., Derbal-Wolfrom, L., Cattin, A.-L., Benahmed, F., Martin, E., … Duluc, I. (2013). Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene, 32(32), 3782–3788. https://doi.org/10.1038/onc.2012.401
Guéant, J.-L., Caillerez-Fofou, M., Battaglia-Hsu, S., Alberto, J.-M., Freund, J.-N., Duluc, I., … Daval, J.-L. (2013). Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie, 95(5), 1033–1040. https://doi.org/10.1016/j.biochi.2013.01.020
Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., … De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341. https://doi.org/10.1083/jcb.201204086
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., … Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469. https://doi.org/10.1093/nar/gkr1242
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., … Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474. https://doi.org/10.1242/dev.070722
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298. https://doi.org/10.1136/gut.2010.222323
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., … Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727. https://doi.org/10.1542/peds.2009-3512
Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., … Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell, 17(4), 516–526. https://doi.org/10.1016/j.devcel.2009.08.010
Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M.-T., Valanzano, R., … Moschetta, A. (2009). Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut, 58(9), 1250–1259. https://doi.org/10.1136/gut.2008.158386
Benahmed, F., Gross, I., Gaunt, S. J., Beck, F., Jehan, F., Domon-Dell, C., … Duluc, I. (2008). Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology, 135(4), 1238–1247, 1247.e1-3. https://doi.org/10.1053/j.gastro.2008.06.045
Barros, R., Pereira, B., Duluc, I., Azevedo, M., Mendes, N., Camilo, V., … Almeida, R. (2008). Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. The Journal of Pathology, 215(4), 411–420. https://doi.org/10.1002/path.2369
Bonhomme, C., Calon, A., Martin, E., Robine, S., Neuville, A., Kedinger, M., … Freund, J.-N. (2008). Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene, 27(32), 4497–4502. https://doi.org/10.1038/onc.2008.78
Gross, I., Duluc, I., Benameur, T., Calon, A., Martin, E., Brabletz, T., … Freund, J.-N. (2008). The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene, 27(1), 107–115. https://doi.org/10.1038/sj.onc.1210601
Calon, A., Gross, I., Lhermitte, B., Martin, E., Beck, F., Duclos, B., … Freund, J.-N. (2007). Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut, 56(12), 1688–1695. https://doi.org/10.1136/gut.2007.125542
Subtil, C., Guérin, E., Schneider, A., Chenard, M.-P., Martin, E., Domon-Dell, C., … Freund, J.-N. (2007). Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Letters, 247(2), 197–203. https://doi.org/10.1016/j.canlet.2006.04.004
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., … Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744. https://doi.org/10.2353/ajpath.2007.060696
Calon, A., Gross, I., Davidson, I., Kedinger, M., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2007). Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Research, 35(1), 175–185. https://doi.org/10.1093/nar/gkl1034
Guenot, D., Guérin, E., Aguillon-Romain, S., Pencreach, E., Schneider, A., Neuville, A., … Gaub, M.-P. (2006). Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability. The Journal of Pathology, 208(5), 643–652. https://doi.org/10.1002/path.1936
Gross, I., Lhermitte, B., Domon-Dell, C., Duluc, I., Martin, E., Gaiddon, C., … Freund, J.-N. (2005). Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene, 24(54), 7955–7963. https://doi.org/10.1038/sj.onc.1208945
Brabletz, T., Spaderna, S., Kolb, J., Hlubek, F., Faller, G., Bruns, C. J., … Freund, J.-N. (2004). Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Research, 64(19), 6973–6977. https://doi.org/10.1158/0008-5472.CAN-04-1132
Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., … Jay, P. (2004). SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology, 166(1), 37–47. https://doi.org/10.1083/jcb.200311021
Bonhomme, C., Duluc, I., Martin, E., Chawengsaksophak, K., Chenard, M.-P., Kedinger, M., … Domon-Dell, C. (2003). The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut, 52(10), 1465–1471.
Domon-Dell, C., Schneider, A., Moucadel, V., Guerin, E., Guenot, D., Aguillon, S., … Freund, J.-N. (2003). Cdx1 homeobox gene during human colon cancer progression. Oncogene, 22(39), 7913–7921. https://doi.org/10.1038/sj.onc.1206756
Ratineau, C., Duluc, I., Pourreyron, C., Kedinger, M., Freund, J.-N., & Roche, C. (2003). Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat. Differentiation; Research in Biological Diversity, 71(2), 163–169. https://doi.org/10.1046/j.1432-0436.2003.t01-1-710203.x
Jenny, M., Uhl, C., Roche, C., Duluc, I., Guillermin, V., Guillemot, F., … Gradwohl, G. (2002). Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. The EMBO Journal, 21(23), 6338–6347.
Duluc, I., Hoff, C., Kedinger, M., & Freund, J. N. (2001). Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine. Genesis (New York, N.Y.: 2000), 29(2), 55–59.
Lickert, H., Domon, C., Huls, G., Wehrle, C., Duluc, I., Clevers, H., … Kemler, R. (2000). Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development (Cambridge, England), 127(17), 3805–3813.
Domon-Dell, C., Duluc, I., Kedinger, M., & Freund, J. N. (2000). Homeobox genes and intestinal development. (T. Andus, G. Rogler, K. Schlottmann, E. Frick, G. Adler, M. Zeitz, … J. Scholmerich, Eds.) (Vol. 113). Dordrecht: Springer.
Jost, B., Vilotte, J. L., Duluc, I., Rodeau, J. L., & Freund, J. N. (1999). Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland. Nature Biotechnology, 17(2), 160–164. https://doi.org/10.1038/6158
Lorentz, O., Cadoret, A., Duluc, I., Capeau, J., Gespach, C., Cherqui, G., & Freund, J. N. (1999). Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene, 18(1), 87–92. https://doi.org/10.1038/sj.onc.1202280
Kedinger, M., Duluc, I., Fritsch, C., Lorentz, O., Plateroti, M., & Freund, J. N. (1998). Intestinal epithelial-mesenchymal cell interactions. Annals of the New York Academy of Sciences, 859, 1–17.
Jost, B., Duluc, I., Vilotte, J. L., & Freund, J. N. (1998). Lactase is unchanged in suckling mice fed with lactose-free milk. Gastroenterologie Clinique Et Biologique, 22(11), 863–867.
Kedinger, M., Lefebvre, O., Duluc, I., Freund, J. N., & Simon-Assmann, P. (1998). Cellular and molecular partners involved in gut morphogenesis and differentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 353(1370), 847–856. https://doi.org/10.1098/rstb.1998.0249
Plateroti, M., Rubin, D. C., Duluc, I., Singh, R., Foltzer-Jourdainne, C., Freund, J. N., & Kedinger, M. (1998). Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics. The American Journal of Physiology, 274(5 Pt 1), G945-954.
Freund, J. N., Domon-Dell, C., Kedinger, M., & Duluc, I. (1998). The Cdx-1 and Cdx-2 homeobox genes in the intestine. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 76(6), 957–969.
Lorentz, O., Duluc, I., Arcangelis, A. D., Simon-Assmann, P., Kedinger, M., & Freund, J. N. (1997). Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. The Journal of Cell Biology, 139(6), 1553–1565.
Jost, B., Duluc, I., Richardson, M., Lathe, R., & Freund, J. N. (1997). Functional diversity and interactions between the repeat domains of rat intestinal lactase. The Biochemical Journal, 327 ( Pt 1), 95–103.
Duluc, I., Lorentz, O., Fritsch, C., Leberquier, C., Kedinger, M., & Freund, J. N. (1997). Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells. Journal of Cell Science, 110 ( Pt 11), 1317–1324.