Miller, J. J., Orvain, C., Jozi, S., Clarke, R. M., Smith, J. R., Blanchet, A., Gaiddon, C., Warren, J. J., & Storr, T. (2018). Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer. Chemistry (Weinheim an Der Bergstrasse, Germany), 24(67), 17734–17742. https://doi.org/10.1002/chem.201802677
Vidimar, V., Meng, X., Klajner, M., Licona, C., Fetzer, L., Harlepp, S., Hébraud, P., Sidhoum, M., Sirlin, C., Loeffler, J.-P., Mellitzer, G., Sava, G., Pfeffer, M., & Gaiddon, C. (2012). Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochemical Pharmacology, 84(11), 1428–1436. https://doi.org/10.1016/j.bcp.2012.08.022
Ribeiro, N., Thuaud, F., Bernard, Y., Gaiddon, C., Cresteil, T., Hild, A., Hirsch, E. C., Michel, P. P., Nebigil, C. G., & Désaubry, L. (2012). Flavaglines as potent anticancer and cytoprotective agents. Journal of Medicinal Chemistry, 55(22), 10064–10073. https://doi.org/10.1021/jm301201z
Bergamo, A., Gaiddon, C., Schellens, J. H. M., Beijnen, J. H., & Sava, G. (2012). Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates. Journal of Inorganic Biochemistry, 106(1), 90–99. https://doi.org/10.1016/j.jinorgbio.2011.09.030
Benosman, S., Meng, X., Von Grabowiecki, Y., Palamiuc, L., Hritcu, L., Gross, I., Mellitzer, G., Taya, Y., Loeffler, J.-P., & Gaiddon, C. (2011). Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. The Journal of Biological Chemistry, 286(50), 43013–43025. https://doi.org/10.1074/jbc.M111.261271
Fetzer, L., Boff, B., Ali, M., Xiangjun, M., Collin, J.-P., Sirlin, C., Gaiddon, C., & Pfeffer, M. (2011). Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier. Dalton Transactions (Cambridge, England: 2003), 40(35), 8869–8878. https://doi.org/10.1039/c1dt10322a
Thuaud, F., Ribeiro, N., Gaiddon, C., Cresteil, T., & Désaubry, L. (2011). Novel flavaglines displaying improved cytotoxicity. Journal of Medicinal Chemistry, 54(1), 411–415. https://doi.org/10.1021/jm101318b
Klajner, M., Hebraud, P., Sirlin, C., Gaiddon, C., & Harlepp, S. (2010). DNA binding to an anticancer organo-ruthenium complex. The Journal of Physical Chemistry. B, 114(44), 14041–14047. https://doi.org/10.1021/jp1044783
Meng, X., Leyva, M. L., Jenny, M., Gross, I., Benosman, S., Fricker, B., Harlepp, S., Hébraud, P., Boos, A., Wlosik, P., Bischoff, P., Sirlin, C., Pfeffer, M., Loeffler, J.-P., & Gaiddon, C. (2009). A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. Cancer Research, 69(13), 5458–5466. https://doi.org/10.1158/0008-5472.CAN-08-4408
Ohtsubo, C., Shiokawa, D., Kodama, M., Gaiddon, C., Nakagama, H., Jochemsen, A. G., Taya, Y., & Okamoto, K. (2009). Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2. Cancer Science, 100(7), 1291–1299. https://doi.org/10.1111/j.1349-7006.2009.01180.x
Benosman, S., Gross, I., Clarke, N., Jochemsen, A. G., Okamoto, K., Loeffler, J.-P., & Gaiddon, C. (2007). Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death and Differentiation, 14(12), 2047–2057. https://doi.org/10.1038/sj.cdd.4402216
Gross, I., Armant, O., Benosman, S., de Aguilar, J. L. G., Freund, J.-N., Kedinger, M., Licht, J. D., Gaiddon, C., & Loeffler, J.-P. (2007). Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell Death and Differentiation, 14(10), 1802–1812. https://doi.org/10.1038/sj.cdd.4402188
Lokshin, M., Li, Y., Gaiddon, C., & Prives, C. (2007). p53 and p73 display common and distinct requirements for sequence specific binding to DNA. Nucleic Acids Research, 35(1), 340–352. https://doi.org/10.1093/nar/gkl1047
Gross, I., Lhermitte, B., Domon-Dell, C., Duluc, I., Martin, E., Gaiddon, C., Kedinger, M., & Freund, J.-N. (2005). Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene, 24(54), 7955–7963. https://doi.org/10.1038/sj.onc.1208945
Gaiddon, C., Jeannequin, P., Bischoff, P., Pfeffer, M., Sirlin, C., & Loeffler, J. P. (2005). Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms. The Journal of Pharmacology and Experimental Therapeutics, 315(3), 1403–1411. https://doi.org/10.1124/jpet.105.089342
Di Scala, F., Dupuis, L., Gaiddon, C., De Tapia, M., Jokic, N., Gonzalez de Aguilar, J.-L., Raul, J.-S., Ludes, B., & Loeffler, J.-P. (2005). Tissue specificity and regulation of the N-terminal diversity of reticulon 3. The Biochemical Journal, 385(Pt 1), 125–134. https://doi.org/10.1042/BJ20040458
Gaiddon, C., Lokshin, M., Gross, I., Levasseur, D., Taya, Y., Loeffler, J.-P., & Prives, C. (2003). Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. The Journal of Biological Chemistry, 278(30), 27421–27431. https://doi.org/10.1074/jbc.M300251200
Gaiddon, C., Lokshin, M., Ahn, J., Zhang, T., & Prives, C. (2001). A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Molecular and Cellular Biology, 21(5), 1874–1887. https://doi.org/10.1128/MCB.21.5.1874-1887.2001
González de Aguilar, J. L., Gordon, J. W., René, F., de Tapia, M., Lutz-Bucher, B., Gaiddon, C., & Loeffler, J. P. (2000). Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway. Neurobiology of Disease, 7(4), 406–415. https://doi.org/10.1006/nbdi.2000.0295
Gaiddon, C., Moorthy, N. C., & Prives, C. (1999). Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. The EMBO Journal, 18(20), 5609–5621. https://doi.org/10.1093/emboj/18.20.5609
Gaiddon, C., Larmet, Y., Trinh, E., Boutillier, A. L., Sommer, B., & Loeffler, J. P. (1999). Brain-derived neurotrophic factor exerts opposing effects on beta2-adrenergic receptor according to depolarization status of cerebellar neurons. Journal of Neurochemistry, 73(4), 1467–1476.
Gaiddon, C., de Tapia, M., & Loeffler, J. P. (1999). The tissue-specific transcription factor Pit-1/GHF-1 binds to the c-fos serum response element and activates c-fos transcription. Molecular Endocrinology (Baltimore, Md.), 13(5), 742–751. https://doi.org/10.1210/mend.13.5.0275
Sohm, F., Gaiddon, C., Antoine, M., Boutillier, A. L., & Loeffler, J. P. (1999). The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity. Oncogene, 18(17), 2762–2769. https://doi.org/10.1038/sj.onc.1202634
Di Como, C. J., Gaiddon, C., & Prives, C. (1999). p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Molecular and Cellular Biology, 19(2), 1438–1449.
Boutillier, A. L., Gaiddon, C., Lorang, D., Roberts, J. L., & Loeffler, J. P. (1998). Transcriptional activation of the proopiomelanocortin gene by cyclic AMP-responsive element binding protein. Pituitary, 1(1), 33–43.
Cabot, P. J., Carter, L., Gaiddon, C., Zhang, Q., Schäfer, M., Loeffler, J. P., & Stein, C. (1997). Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats. The Journal of Clinical Investigation, 100(1), 142–148. https://doi.org/10.1172/JCI119506
René, F., Monnier, D., Gaiddon, C., Félix, J. M., & Loeffler, J. P. (1996). Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes. Neuroendocrinology, 64(1), 2–13. https://doi.org/10.1159/000127091
Antoine, M., Gaiddon, C., & Loeffler, J. P. (1996). Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line. Molecular and Cellular Endocrinology, 120(1), 1–8.
Gaiddon, C., Loeffler, J. P., & Larmet, Y. (1996). Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. Journal of Neurochemistry, 66(6), 2279–2286.
Gaiddon, C., Tian, J., Loeffler, J. P., & Bancroft, C. (1996). Constitutively active G(S) alpha-subunits stimulate Pit-1 promoter activity via a protein kinase A-mediated pathway acting through deoxyribonucleic acid binding sites both for Pit-1 and for adenosine 3’,5’-monophosphate response element-binding protein. Endocrinology, 137(4), 1286–1291. https://doi.org/10.1210/endo.137.4.8625901
Gaiddon, C., Mercken, L., Bancroft, C., & Loeffler, J. P. (1995). Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3’,5’-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A. Endocrinology, 136(10), 4331–4338. https://doi.org/10.1210/endo.136.10.7664652
Gaiddon, C., Boutillier, A. L., Monnier, D., Mercken, L., & Loeffler, J. P. (1994). Genomic effects of the putative oncogene G alpha s. Chronic transcriptional activation of the c-fos proto-oncogene in endocrine cells. The Journal of Biological Chemistry, 269(36), 22663–22671.