Publications Jean-Noël FREUND avant 2013

Freund, J.-N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Annales De Pathologie, 32(5 Suppl), S24-27.
Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in Molecular Medicine, 18(9), 555–563.
Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A., & Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. Journal of Biological Regulators and Homeostatic Agents, 26(3), 515–526.
Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R. G., Freund, J.-N., & De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341.
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3.
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., Duluc, I., Gross, I., Freund, J.-N., & Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469.
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J.-N., Deschamps, J., & Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474.
Kocgozlu, L., Rabineau, M., Koenig, G., Haikel, Y., Schaaf, P., Freund, J.-N., Voegel, J.-C., Lavalle, P., & Vautier, D. (2012). The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity. Biomaterials, 33(3), 798–809.
Reimund, J.-M., Tavernier, M., Viennot, S., Hussein, I. A. H., Dupont, B., Justum, A.-M., Jurjus, A. R., Freund, J.-N., & Lechevrel, M. (2012). Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives.
van de Ven, C., Bialecka, M., Neijts, R., Young, T., Rowland, J. E., Stringer, E. J., Van Rooijen, C., Meijlink, F., Nóvoa, A., Freund, J.-N., Mallo, M., Beck, F., & Deschamps, J. (2011). Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development (Cambridge, England), 138(16), 3451–3462.
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298.
Laurent, C., Svrcek, M., Flejou, J.-F., Chenard, M.-P., Duclos, B., Freund, J.-N., & Reimund, J.-M. (2011). Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. Inflammatory Bowel Diseases, 17(1), 232–240.
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., Simo-Noumbissie, P., Guérin, E., Gaub, M.-P., Freund, J.-N., Boehm, N., Constantinesco, A., Lutz, P., Guenot, D., & Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., Gross, I., Rowland, J., Kim, S., & Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727.
Coant, N., Ben Mkaddem, S., Pedruzzi, E., Guichard, C., Tréton, X., Ducroc, R., Freund, J.-N., Cazals-Hatem, D., Bouhnik, Y., Woerther, P.-L., Skurnik, D., Grodet, A., Fay, M., Biard, D., Lesuffleur, T., Deffert, C., Moreau, R., Groyer, A., Krause, K.-H., … Ogier-Denis, E. (2010). NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Molecular and Cellular Biology, 30(11), 2636–2650.
Barros, R., Camilo, V., Pereira, B., Freund, J.-N., David, L., & Almeida, R. (2010). Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochemical Society Transactions, 38(2), 358–363.
Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W., Duluc, I., Freund, J.-N., Beck, F., Mallo, M., & Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell, 17(4), 516–526.
Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M.-T., Valanzano, R., Esposito, D. L., Palasciano, G., Duluc, I., Freund, J.-N., Mariani-Costantini, R., & Moschetta, A. (2009). Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut, 58(9), 1250–1259.
Pons, L., Battaglia-Hsu, S.-F., Orozco-Barrios, C. E., Ortiou, S., Chery, C., Alberto, J.-M., Arango-Rodriguez, M. L., Dumas, D., Martinez-Fong, D., Freund, J.-N., & Gueant, J.-L. (2009). Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. PloS One, 4(7), e6325.
Salehi, S., Eckley, L., Sawyer, G. J., Zhang, X., Dong, X., Freund, J.-N., & Fabre, J. W. (2009). Intestinal lactase as an autologous beta-galactosidase reporter gene for in vivo gene expression studies. Human Gene Therapy, 20(1), 21–30.
Benahmed, F., Gross, I., Gaunt, S. J., Beck, F., Jehan, F., Domon-Dell, C., Martin, E., Kedinger, M., Freund, J.-N., & Duluc, I. (2008). Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology, 135(4), 1238–1247, 1247.e1-3.
Barros, R., Pereira, B., Duluc, I., Azevedo, M., Mendes, N., Camilo, V., Jacobs, R. J., Paulo, P., Santos-Silva, F., van Seuningen, I., van den Brink, G. R., David, L., Freund, J.-N., & Almeida, R. (2008). Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. The Journal of Pathology, 215(4), 411–420.
Bonhomme, C., Calon, A., Martin, E., Robine, S., Neuville, A., Kedinger, M., Domon-Dell, C., Duluc, I., & Freund, J.-N. (2008). Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene, 27(32), 4497–4502.
Hajj Hussein, I.-A., Tohme, R., Barada, K., Mostafa, M. H., Freund, J.-N., Jurjus, R. A., Karam, W., & Jurjus, A. (2008). Inflammatory bowel disease in rats: bacterial and chemical interaction. World Journal of Gastroenterology, 14(25), 4028–4039.
Lu, X., Freund, J.-N., Muller, M., Ravey, J., Nicolas, J.-P., Gueant, J.-L., & Namour, F. (2008). Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. Biochimie, 90(5), 697–704.
Gross, I., Duluc, I., Benameur, T., Calon, A., Martin, E., Brabletz, T., Kedinger, M., Domon-Dell, C., & Freund, J.-N. (2008). The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene, 27(1), 107–115.
Reimund, J.-M., & Freund, J.-N. (2008). Inflammatory Bowel Disease-associated Cancer. In M. Schwab (Ed.), Encyclopedia of Cancer (pp. 1525–1528). Springer Berlin Heidelberg.
Calon, A., Gross, I., Lhermitte, B., Martin, E., Beck, F., Duclos, B., Kedinger, M., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2007). Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut, 56(12), 1688–1695.
Choquet, P., Calon, A., Breton, E., Beck, F., Domon-Dell, C., Freund, J.-N., & Constantinesco, A. (2007). Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. Comptes Rendus Biologies, 330(11), 821–827.
Gross, I., Armant, O., Benosman, S., de Aguilar, J. L. G., Freund, J.-N., Kedinger, M., Licht, J. D., Gaiddon, C., & Loeffler, J.-P. (2007). Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell Death and Differentiation, 14(10), 1802–1812.
Jonckheere, N., Vincent, A., Perrais, M., Ducourouble, M.-P., Male, A. K., Aubert, J.-P., Pigny, P., Carraway, K. L., Freund, J.-N., Renes, I. B., & Van Seuningen, I. (2007). The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. The Journal of Biological Chemistry, 282(31), 22638–22650.
Coste, I., Freund, J.-N., Spaderna, S., Brabletz, T., & Renno, T. (2007). Precancerous lesions upon sporadic activation of beta-catenin in mice. Gastroenterology, 132(4), 1299–1308.
Subtil, C., Guérin, E., Schneider, A., Chenard, M.-P., Martin, E., Domon-Dell, C., Duluc, I., Brabletz, T., Kedinger, M., Duclos, B., Gaub, M.-P., & Freund, J.-N. (2007). Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Letters, 247(2), 197–203.
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., Brabletz, T., Kedinger, M., Freund, J.-N., & Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744.
Calon, A., Gross, I., Davidson, I., Kedinger, M., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2007). Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Research, 35(1), 175–185.
Buchet-Poyau, K., Courchet, J., Le Hir, H., Séraphin, B., Scoazec, J.-Y., Duret, L., Domon-Dell, C., Freund, J.-N., & Billaud, M. (2007). Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Research, 35(4), 1289–1300.
Debruyne, P. R., Witek, M., Gong, L., Birbe, R., Chervoneva, I., Jin, T., Domon-Cell, C., Palazzo, J. P., Freund, J.-N., Li, P., Pitari, G. M., Schulz, S., & Waldman, S. A. (2006). Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology, 130(4), 1191–1206.
Kim, H.-S., Lee, J.-S., Freund, J.-N., Min, K.-W., Lee, J.-S., Kim, W., Juhng, S.-W., & Park, C.-S. (2006). CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions. Journal of Gastroenterology and Hepatology, 21(2), 438–442.
Gross, I., Lhermitte, B., Domon-Dell, C., Duluc, I., Martin, E., Gaiddon, C., Kedinger, M., & Freund, J.-N. (2005). Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene, 24(54), 7955–7963.
Turck, N., Gross, I., Gendry, P., Stutzmann, J., Freund, J.-N., Kedinger, M., Simon-Assmann, P., & Launay, J.-F. (2005). Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Experimental Cell Research, 303(2), 494–503.
Kedinger, M., & Freund, J.-N. (2005). Gut Epithelium. In Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (pp. 736–739). Springer Berlin Heidelberg.
Wang, L., Klopot, A., Freund, J.-N., Dowling, L. N., Krasinski, S. D., & Fleet, J. C. (2004). Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. American Journal of Physiology. Gastrointestinal and Liver Physiology, 287(5), G943-953.
Brabletz, T., Spaderna, S., Kolb, J., Hlubek, F., Faller, G., Bruns, C. J., Jung, A., Nentwich, J., Duluc, I., Domon-Dell, C., Kirchner, T., & Freund, J.-N. (2004). Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Research, 64(19), 6973–6977.
Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., Clevers, H., & Jay, P. (2004). SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology, 166(1), 37–47.
Tohyama, O., Imura, A., Iwano, A., Freund, J.-N., Henrissat, B., Fujimori, T., & Nabeshima, Y. (2004). Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. The Journal of Biological Chemistry, 279(11), 9777–9784.
Kim, S.-P., Park, J.-W., Lee, S.-H., Lim, J. H., Jang, B.-C., Lee, S.-H., Jang, I.-H., Freund, J.-N., Suh, S.-I., Mun, K. C., Song, D.-K., Ha, E.-M., Lee, W.-J., & Kwon, T. K. (2004). Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. Biochemical and Biophysical Research Communications, 315(1), 93–99.
Kim, S., Domon-Dell, C., Kang, J., Chung, D. H., Freund, J.-N., & Evers, B. M. (2004). Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. The Journal of Biological Chemistry, 279(6), 4285–4291.
Reimund, Jean-Marie, Laurent, Camille, Chenard, M.-P., Bellocq, Jean-Pierre, Freund, J.-N., Kedinger, Michèle, Duclos, Bernard, & Baumann René. (2003). Cancer colorectal au cours de la rectocolite hémorragique. Hépato-Gastro, 6(10), 415–423.
Bonhomme, C., Duluc, I., Martin, E., Chawengsaksophak, K., Chenard, M.-P., Kedinger, M., Beck, F., Freund, J.-N., & Domon-Dell, C. (2003). The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut, 52(10), 1465–1471.
Gautier-Stein, A., Domon-Dell, C., Calon, A., Bady, I., Freund, J.-N., Mithieux, G., & Rajas, F. (2003). Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2. Nucleic Acids Research, 31(18), 5238–5246.