Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R. G., Freund, J.-N., & De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341. https://doi.org/10.1083/jcb.201204086
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., Duluc, I., Gross, I., Freund, J.-N., & Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469. https://doi.org/10.1093/nar/gkr1242
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J.-N., Deschamps, J., & Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474. https://doi.org/10.1242/dev.070722
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298. https://doi.org/10.1136/gut.2010.222323
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., Gross, I., Rowland, J., Kim, S., & Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727. https://doi.org/10.1542/peds.2009-3512
Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W., Duluc, I., Freund, J.-N., Beck, F., Mallo, M., & Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell, 17(4), 516–526. https://doi.org/10.1016/j.devcel.2009.08.010
Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M.-T., Valanzano, R., Esposito, D. L., Palasciano, G., Duluc, I., Freund, J.-N., Mariani-Costantini, R., & Moschetta, A. (2009). Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut, 58(9), 1250–1259. https://doi.org/10.1136/gut.2008.158386
Benahmed, F., Gross, I., Gaunt, S. J., Beck, F., Jehan, F., Domon-Dell, C., Martin, E., Kedinger, M., Freund, J.-N., & Duluc, I. (2008). Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology, 135(4), 1238–1247, 1247.e1-3. https://doi.org/10.1053/j.gastro.2008.06.045
Barros, R., Pereira, B., Duluc, I., Azevedo, M., Mendes, N., Camilo, V., Jacobs, R. J., Paulo, P., Santos-Silva, F., van Seuningen, I., van den Brink, G. R., David, L., Freund, J.-N., & Almeida, R. (2008). Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. The Journal of Pathology, 215(4), 411–420. https://doi.org/10.1002/path.2369
Bonhomme, C., Calon, A., Martin, E., Robine, S., Neuville, A., Kedinger, M., Domon-Dell, C., Duluc, I., & Freund, J.-N. (2008). Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene, 27(32), 4497–4502. https://doi.org/10.1038/onc.2008.78
Gross, I., Duluc, I., Benameur, T., Calon, A., Martin, E., Brabletz, T., Kedinger, M., Domon-Dell, C., & Freund, J.-N. (2008). The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene, 27(1), 107–115. https://doi.org/10.1038/sj.onc.1210601
Calon, A., Gross, I., Lhermitte, B., Martin, E., Beck, F., Duclos, B., Kedinger, M., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2007). Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut, 56(12), 1688–1695. https://doi.org/10.1136/gut.2007.125542
Subtil, C., Guérin, E., Schneider, A., Chenard, M.-P., Martin, E., Domon-Dell, C., Duluc, I., Brabletz, T., Kedinger, M., Duclos, B., Gaub, M.-P., & Freund, J.-N. (2007). Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Letters, 247(2), 197–203. https://doi.org/10.1016/j.canlet.2006.04.004
Benahmed, F., Gross, I., Guenot, D., Jehan, F., Martin, E., Domon-Dell, C., Brabletz, T., Kedinger, M., Freund, J.-N., & Duluc, I. (2007). The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. The American Journal of Pathology, 170(2), 733–744. https://doi.org/10.2353/ajpath.2007.060696
Calon, A., Gross, I., Davidson, I., Kedinger, M., Duluc, I., Domon-Dell, C., & Freund, J.-N. (2007). Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Research, 35(1), 175–185. https://doi.org/10.1093/nar/gkl1034
Gross, I., Lhermitte, B., Domon-Dell, C., Duluc, I., Martin, E., Gaiddon, C., Kedinger, M., & Freund, J.-N. (2005). Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene, 24(54), 7955–7963. https://doi.org/10.1038/sj.onc.1208945
Brabletz, T., Spaderna, S., Kolb, J., Hlubek, F., Faller, G., Bruns, C. J., Jung, A., Nentwich, J., Duluc, I., Domon-Dell, C., Kirchner, T., & Freund, J.-N. (2004). Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Research, 64(19), 6973–6977. https://doi.org/10.1158/0008-5472.CAN-04-1132
Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., Clevers, H., & Jay, P. (2004). SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology, 166(1), 37–47. https://doi.org/10.1083/jcb.200311021
Bonhomme, C., Duluc, I., Martin, E., Chawengsaksophak, K., Chenard, M.-P., Kedinger, M., Beck, F., Freund, J.-N., & Domon-Dell, C. (2003). The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut, 52(10), 1465–1471.
Domon-Dell, C., Schneider, A., Moucadel, V., Guerin, E., Guenot, D., Aguillon, S., Duluc, I., Martin, E., Iovanna, J., Launay, J.-F., Duclos, B., Chenard, M.-P., Meyer, C., Oudet, P., Kedinger, M., Gaub, M.-P., & Freund, J.-N. (2003). Cdx1 homeobox gene during human colon cancer progression. Oncogene, 22(39), 7913–7921. https://doi.org/10.1038/sj.onc.1206756
Ratineau, C., Duluc, I., Pourreyron, C., Kedinger, M., Freund, J.-N., & Roche, C. (2003). Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat. Differentiation; Research in Biological Diversity, 71(2), 163–169. https://doi.org/10.1046/j.1432-0436.2003.t01-1-710203.x
Jenny, M., Uhl, C., Roche, C., Duluc, I., Guillermin, V., Guillemot, F., Jensen, J., Kedinger, M., & Gradwohl, G. (2002). Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. The EMBO Journal, 21(23), 6338–6347.
Duluc, I., Hoff, C., Kedinger, M., & Freund, J. N. (2001). Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine. Genesis (New York, N.Y.: 2000), 29(2), 55–59.
Lickert, H., Domon, C., Huls, G., Wehrle, C., Duluc, I., Clevers, H., Meyer, B. I., Freund, J. N., & Kemler, R. (2000). Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development (Cambridge, England), 127(17), 3805–3813.
Domon-Dell, C., Duluc, I., Kedinger, M., & Freund, J. N. (2000). Homeobox genes and intestinal development (T. Andus, G. Rogler, K. Schlottmann, E. Frick, G. Adler, M. Zeitz, W. Schmiegel, & J. Scholmerich, Eds.; Vol. 113). Springer.
Jost, B., Vilotte, J. L., Duluc, I., Rodeau, J. L., & Freund, J. N. (1999). Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland. Nature Biotechnology, 17(2), 160–164. https://doi.org/10.1038/6158
Lorentz, O., Cadoret, A., Duluc, I., Capeau, J., Gespach, C., Cherqui, G., & Freund, J. N. (1999). Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene, 18(1), 87–92. https://doi.org/10.1038/sj.onc.1202280
Kedinger, M., Duluc, I., Fritsch, C., Lorentz, O., Plateroti, M., & Freund, J. N. (1998). Intestinal epithelial-mesenchymal cell interactions. Annals of the New York Academy of Sciences, 859, 1–17.
Jost, B., Duluc, I., Vilotte, J. L., & Freund, J. N. (1998). Lactase is unchanged in suckling mice fed with lactose-free milk. Gastroenterologie Clinique Et Biologique, 22(11), 863–867.
Kedinger, M., Lefebvre, O., Duluc, I., Freund, J. N., & Simon-Assmann, P. (1998). Cellular and molecular partners involved in gut morphogenesis and differentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 353(1370), 847–856. https://doi.org/10.1098/rstb.1998.0249
Plateroti, M., Rubin, D. C., Duluc, I., Singh, R., Foltzer-Jourdainne, C., Freund, J. N., & Kedinger, M. (1998). Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics. The American Journal of Physiology, 274(5 Pt 1), G945-954.
Freund, J. N., Domon-Dell, C., Kedinger, M., & Duluc, I. (1998). The Cdx-1 and Cdx-2 homeobox genes in the intestine. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 76(6), 957–969.
Lorentz, O., Duluc, I., Arcangelis, A. D., Simon-Assmann, P., Kedinger, M., & Freund, J. N. (1997). Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. The Journal of Cell Biology, 139(6), 1553–1565.
Jost, B., Duluc, I., Richardson, M., Lathe, R., & Freund, J. N. (1997). Functional diversity and interactions between the repeat domains of rat intestinal lactase. The Biochemical Journal, 327 ( Pt 1), 95–103.
Duluc, I., Lorentz, O., Fritsch, C., Leberquier, C., Kedinger, M., & Freund, J. N. (1997). Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells. Journal of Cell Science, 110 ( Pt 11), 1317–1324.
Freund, J. N., Jost, B., Lorentz, O., & Duluc, I. (1997). Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs). The Biochemical Journal, 322 ( Pt 2), 491–498.
Kedinger, M., Plateroti, M., Orian-Rousseau, V., Lorentz, O., Fritsch, C., De Arcangelis, A., Evans, G., Duluc, I., Freund, J. N., & Simon-Assmann, P. (1997). Cellular and molecular mechanisms regulating intestinal development (F. Halter, D. Winton, & N. A. Wright, Eds.; Vol. 94). Springer.
Boukamel, R., Neuville, P., Duluc, I., & Freund, J. N. (1995). Activity of the rat lactase gene promoter in transfected human colon cancer cells. Comptes Rendus de l’Academie Des Sciences. Serie III, Sciences de La Vie, 318(11), 1133–1140.
Freund, J. N., Jost, B., Duluc, I., & Morel, G. (1995). Ultrastructural study of intestinal lactase gene expression. Biology of the Cell, 83(2–3), 211–217.
Duluc, I., Freund, J. N., Leberquier, C., & Kedinger, M. (1994). Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development. The Journal of Cell Biology, 126(1), 211–221.
Nsi-Emvo, E., Foltzer-Jourdainne, C., Raul, F., Gosse, F., Duluc, I., Koch, B., & Freund, J. N. (1994). Precocious and reversible expression of sucrase-isomaltase unrelated to intestinal cell turnover. The American Journal of Physiology, 266(4 Pt 1), G568-575.
Duluc, I., Jost, B., & Freund, J. N. (1993). Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase. The Journal of Cell Biology, 123(6 Pt 1), 1577–1586.
Freund, J., Boukamel, R., & Duluc, I. (1993). Levels and Factors of Control of Small-Intestinal Lactase Expression in the Laboratory Rat (S. Auricchio & G. Semenza, Eds.; Vol. 3). Karger.
Duluc, I., Galluser, M., Raul, F., & Freund, J. N. (1992). Dietary control of the lactase mRNA distribution along the rat small intestine. The American Journal of Physiology, 262(6 Pt 1), G954-961.
Duluc, I., Boukamel, R., Mantei, N., Semenza, G., Raul, F., & Freund, J. N. (1991). Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat. Gene, 103(2), 275–276.
Freund, J. N., Duluc, I., & Raul, F. (1991). Lactase expression is controlled differently in the jejunum and ileum during development in rats. Gastroenterology, 100(2), 388–394.
Galluser, M., Belkhou, R., Freund, J. N., Duluc, I., Torp, N., Danielsen, M., & Raul, F. (1991). Adaptation of intestinal hydrolases to starvation in rats: effect of thyroid function. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, 161(4), 357–361.
Freund, J. N., Foltzer-Jourdainne, C., Duluc, I., Galluser, M., Gosse, F., & Raul, F. (1991). Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status. Cellular and Molecular Biology, 37(4), 463–466.
Freund, J. N., Duluc, I., Foltzer-Jourdainne, C., Gosse, F., & Raul, F. (1990). Specific expression of lactase in the jejunum and colon during postnatal development and hormone treatments in the rat. The Biochemical Journal, 268(1), 99–103.