Jean-Noël FREUND

Directeur d’unité ; Responsable Equipe 1

Lien ORCID – CV Science – ResearcherID – ResearchGate

(+33) 03 88 27 53 52

 

 

 

Liste des publications :

 

Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Nevé, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., de la Fouchardiere, C., & Plateroti, M. (2021). Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy. Cancer Research, 81(10), 2730–2744. https://doi.org/10.1158/0008-5472.CAN-20-2450
Galland, A., Gourain, V., Habbas, K., Güler, Y., Martin, E., Ebel, C., Tavian, M., Vallat, L., Chenard, M.-P., Mauvieux, L., Freund, J.-N., Duluc, I., & Domon-Dell, C. (2021). CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition. Molecular Oncology. https://doi.org/10.1002/1878-0261.12982
Julien, E., Biasch, K., El Omar, R., Freund, J.-N., Gachet, C., Lanza, F., & Tavian, M. (2021). Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells. Stem Cells (Dayton, Ohio), 39(5), 636–649. https://doi.org/10.1002/stem.3339
Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Le Nevé, C., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway. Development (Cambridge, England), 148(8), dev194357. https://doi.org/10.1242/dev.194357
El Omar, R., Julien, E., Biasch, K., Guffroy, B., Lioure, B., Vallat, L., Gross, I., Domon-Dell, C., Lanza, F., Gachet, C., Negroni, M., Freund, J.-N., & Tavian, M. (2021). CDX2 regulates ACE expression in blood development and leukemia cells. Blood Advances, 5(7), 2012–2016. https://doi.org/10.1182/bloodadvances.2020003563
Beck, M., Baranger, M., Moufok-Sadoun, A., Bersuder, E., Hinkel, I., Mellitzer, G., Martin, E., Marisa, L., Duluc, I., de Reynies, A., Gaiddon, C., Freund, J.-N., & Gross, I. (2020). The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Oncogene. https://doi.org/10.1038/s41388-020-01546-y
Tusamda Wakhloo, N., Anders, S., Badique, F., Eichhorn, M., Brigaud, I., Petithory, T., Vassaux, M., Milan, J.-L., Freund, J.-N., Rühe, J., Davidson, P. M., Pieuchot, L., & Anselme, K. (2020). Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography. Biomaterials, 234, 119746. https://doi.org/10.1016/j.biomaterials.2019.119746
Licona, C., Delhorme, J.-B., Riegel, G., Vidimar, V., Cerón-Camacho, R., Boff, B., Venkatasamy, A., Tomasetto, C., da Silva Figueiredo Celestino Gomes, P., Rognan, D., Freund, J.-N., Le Lagadec, R., Pfeffer, M., Gross, I., Mellitzer, G., & Gaiddon, C. (2020). Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms. Inorganic Chemistry Frontiers, 7(3), 678–688. https://doi.org/10.1039/C9QI01148J
Grall, E., Gourain, V., Naïr, A., Martin, E., Birling, M.-C., Freund, J.-N., & Duluc, I. (2019). Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs. Cell Death & Disease, 10(11), 812. https://doi.org/10.1038/s41419-019-2040-0
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Rabineau, M., Flick, F., Ehlinger, C., Mathieu, E., Duluc, I., Jung, M., Senger, B., Kocgozlu, L., Schaaf, P., Lavalle, P., Freund, J.-N., Haikel, Y., & Vautier, D. (2018). Chromatin de-condensation by switching substrate elasticity. Scientific Reports, 8(1), 12655. https://doi.org/10.1038/s41598-018-31023-2
Balbinot, C., Armant, O., Elarouci, N., Marisa, L., Martin, E., De Clara, E., Onea, A., Deschamps, J., Beck, F., Freund, J.-N., & Duluc, I. (2018). The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. The Journal of Experimental Medicine, 215(3), 911–926. https://doi.org/10.1084/jem.20170934
Balbinot, C., Vanier, M., Armant, O., Nair, A., Penichon, J., Soret, C., Martin, E., Saandi, T., Reimund, J.-M., Deschamps, J., Beck, F., Domon-Dell, C., Gross, I., Duluc, I., & Freund, J.-N. (2017). Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death and Differentiation, 24(12), 2173–2186. https://doi.org/10.1038/cdd.2017.140
Dillenseger, J.-P., Goetz, C., Sayeh, A., Healy, C., Duluc, I., Freund, J.-N., Constantinesco, A., Aubertin-Kirch, G., & Choquet, P. (2017). Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. Journal of Medical Imaging (Bellingham, Wash.), 4(3), 035503. https://doi.org/10.1117/1.JMI.4.3.035503
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., Poidevin, L., Bour, C., Freund, J.-N., Duluc, I., Guenot, D., & Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366. https://doi.org/10.18632/oncotarget.16323
Platet, N., Hinkel, I., Richert, L., Murdamoothoo, D., Moufok-Sadoun, A., Vanier, M., Lavalle, P., Gaiddon, C., Vautier, D., Freund, J.-N., & Gross, I. (2017). The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Letters, 386, 57–64. https://doi.org/10.1016/j.canlet.2016.10.040
Reimund, J.-M., & Freund, J.-N. (2017). Inflammatory Bowel Disease-associated Cancer. In M. Schwab (Ed.), Encyclopedia of Cancer (pp. 2256–2263). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_3046
Gillard, L., Billiauws, L., Stan-Iuga, B., Ribeiro-Parenti, L., Jarry, A.-C., Cavin, J.-B., Cluzeaud, F., Mayeur, C., Thomas, M., Freund, J.-N., Lacorte, J.-M., Le Gall, M., Bado, A., Joly, F., & Le Beyec, J. (2016). Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome. Scientific Reports, 6, 28345. https://doi.org/10.1038/srep28345
Soret, C., Martin, E., Duluc, I., Dantzer, F., Vanier, M., Gross, I., Freund, J.-N., & Domon-Dell, C. (2016). Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Letters, 374(2), 208–215. https://doi.org/10.1016/j.canlet.2016.02.026
Freund, J.-N., Duluc, I., Reimund, J.-M., Gross, I., & Domon-Dell, C. (2015). Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World Journal of Gastroenterology, 21(5), 1436–1443. https://doi.org/10.3748/wjg.v21.i5.1436
Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.-N., Duluc, I., Gachet, C., Lanza, F., & Léon, C. (2015). Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage. Journal of Thrombosis and Haemostasis: JTH, 13(1), 115–125. https://doi.org/10.1111/jth.12784
Rabineau, M., Flick, F., Mathieu, E., Tu, A., Senger, B., Voegel, J.-C., Lavalle, P., Schaaf, P., Freund, J.-N., Haikel, Y., & Vautier, D. (2015). Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. Biomaterials, 37, 144–155. https://doi.org/10.1016/j.biomaterials.2014.10.023
Modica, S., Cariello, M., Morgano, A., Gross, I., Vegliante, M. C., Murzilli, S., Salvatore, L., Freund, J.-N., Sabbà, C., & Moschetta, A. (2014). Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). The Journal of Biological Chemistry, 289(41), 28421–28432. https://doi.org/10.1074/jbc.M114.571513
Martianov, I., Cler, E., Duluc, I., Vicaire, S., Philipps, M., Freund, J.-N., & Davidson, I. (2014). TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PloS One, 9(2), e87365. https://doi.org/10.1371/journal.pone.0087365
Tréton, X., Pedruzzi, E., Guichard, C., Ladeiro, Y., Sedghi, S., Vallée, M., Fernandez, N., Bruyère, E., Woerther, P.-L., Ducroc, R., Montcuquet, N., Freund, J.-N., Van Seuningen, I., Barreau, F., Marah, A., Hugot, J.-P., Cazals-Hatem, D., Bouhnik, Y., Daniel, F., & Ogier-Denis, E. (2014). Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PloS One, 9(7), e101669. https://doi.org/10.1371/journal.pone.0101669
Bellis, J., Duluc, I., Freund, J.-N., & De Mey, J. R. (2013). Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum. Bio-Protocol, 3(20), e942. www.bio-protocol.org/e942
Derbal-Wolfrom, L., Pencreach, E., Saandi, T., Aprahamian, M., Martin, E., Greferath, R., Tufa, E., Choquet, P., Lehn, J.-M., Nicolau, C., Duluc, I., & Freund, J.-N. (2013). Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. Oncogene, 32(36), 4313–4318. https://doi.org/10.1038/onc.2012.445
Saandi, T., Baraille, F., Derbal-Wolfrom, L., Cattin, A.-L., Benahmed, F., Martin, E., Cardot, P., Duclos, B., Ribeiro, A., Freund, J.-N., & Duluc, I. (2013). Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene, 32(32), 3782–3788. https://doi.org/10.1038/onc.2012.401
Chery, C., Hehn, A., Mrabet, N., Oussalah, A., Jeannesson, E., Besseau, C., Alberto, J.-M., Gross, I., Josse, T., Gérard, P., Guéant-Rodriguez, R. M., Freund, J.-N., Devignes, J., Bourgaud, F., Peyrin-Biroulet, L., Feillet, F., & Guéant, J.-L. (2013). Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. Biochimie, 95(5), 995–1001. https://doi.org/10.1016/j.biochi.2013.01.022
Guéant, J.-L., Caillerez-Fofou, M., Battaglia-Hsu, S., Alberto, J.-M., Freund, J.-N., Duluc, I., Adjalla, C., Maury, F., Merle, C., Nicolas, J.-P., Namour, F., & Daval, J.-L. (2013). Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie, 95(5), 1033–1040. https://doi.org/10.1016/j.biochi.2013.01.020
De Mey, J. R., & Freund, J.-N. (2013). Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers, 1(2), e24965. https://doi.org/10.4161/tisb.24965
Pereira, B., Sousa, S., Barros, R., Carreto, L., Oliveira, P., Oliveira, C., Chartier, N. T., Plateroti, M., Rouault, J.-P., Freund, J.-N., Billaud, M., & Almeida, R. (2013). CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Research, 41(7), 3986–3999. https://doi.org/10.1093/nar/gkt087
Badique, F., Stamov, D. R., Davidson, P. M., Veuillet, M., Reiter, G., Freund, J.-N., Franz, C. M., & Anselme, K. (2013). Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization. Biomaterials, 34(12), 2991–3001. https://doi.org/10.1016/j.biomaterials.2013.01.018
Rabineau, M., Kocgozlu, L., Dujardin, D., Senger, B., Haikel, Y., Voegel, J.-C., Freund, J.-N., Schaaf, P., Lavalle, P., & Vautier, D. (2013). Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division. PloS One, 8(10), e78468. https://doi.org/10.1371/journal.pone.0078468
Freund, J.-N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Annales De Pathologie, 32(5 Suppl), S24-27. https://doi.org/10.1016/j.annpat.2012.08.005
Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in Molecular Medicine, 18(9), 555–563. https://doi.org/10.1016/j.molmed.2012.07.006
Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A., & Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. Journal of Biological Regulators and Homeostatic Agents, 26(3), 515–526.
Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R. G., Freund, J.-N., & De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341. https://doi.org/10.1083/jcb.201204086
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., Duluc, I., Gross, I., Freund, J.-N., & Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469. https://doi.org/10.1093/nar/gkr1242
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J.-N., Deschamps, J., & Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474. https://doi.org/10.1242/dev.070722
Kocgozlu, L., Rabineau, M., Koenig, G., Haikel, Y., Schaaf, P., Freund, J.-N., Voegel, J.-C., Lavalle, P., & Vautier, D. (2012). The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity. Biomaterials, 33(3), 798–809. https://doi.org/10.1016/j.biomaterials.2011.10.024
Reimund, J.-M., Tavernier, M., Viennot, S., Hussein, I. A. H., Dupont, B., Justum, A.-M., Jurjus, A. R., Freund, J.-N., & Lechevrel, M. (2012). Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives. https://doi.org/10.5772/25577
van de Ven, C., Bialecka, M., Neijts, R., Young, T., Rowland, J. E., Stringer, E. J., Van Rooijen, C., Meijlink, F., Nóvoa, A., Freund, J.-N., Mallo, M., Beck, F., & Deschamps, J. (2011). Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development (Cambridge, England), 138(16), 3451–3462. https://doi.org/10.1242/dev.066118
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298. https://doi.org/10.1136/gut.2010.222323
Laurent, C., Svrcek, M., Flejou, J.-F., Chenard, M.-P., Duclos, B., Freund, J.-N., & Reimund, J.-M. (2011). Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. Inflammatory Bowel Diseases, 17(1), 232–240. https://doi.org/10.1002/ibd.21451
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., Simo-Noumbissie, P., Guérin, E., Gaub, M.-P., Freund, J.-N., Boehm, N., Constantinesco, A., Lutz, P., Guenot, D., & Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., Gross, I., Rowland, J., Kim, S., & Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727. https://doi.org/10.1542/peds.2009-3512