Jean-Noël FREUND

Directeur d’unité ; Responsable Equipe 1

Lien ORCID – CV Science – ResearcherID – ResearchGate

(+33) 03 88 27 53 52

 

 

 

Liste des publications :

 

Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., … Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Rabineau, M., Flick, F., Ehlinger, C., Mathieu, E., Duluc, I., Jung, M., … Vautier, D. (2018). Chromatin de-condensation by switching substrate elasticity. Scientific Reports, 8(1), 12655. https://doi.org/10.1038/s41598-018-31023-2
Balbinot, C., Armant, O., Elarouci, N., Marisa, L., Martin, E., De Clara, E., … Duluc, I. (2018). The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. The Journal of Experimental Medicine, 215(3), 911–926. https://doi.org/10.1084/jem.20170934
Balbinot, C., Vanier, M., Armant, O., Nair, A., Penichon, J., Soret, C., … Freund, J.-N. (2017). Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death and Differentiation, 24(12), 2173–2186. https://doi.org/10.1038/cdd.2017.140
Dillenseger, J.-P., Goetz, C., Sayeh, A., Healy, C., Duluc, I., Freund, J.-N., … Choquet, P. (2017). Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. Journal of Medical Imaging (Bellingham, Wash.), 4(3), 035503. https://doi.org/10.1117/1.JMI.4.3.035503
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., … Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366. https://doi.org/10.18632/oncotarget.16323
Platet, N., Hinkel, I., Richert, L., Murdamoothoo, D., Moufok-Sadoun, A., Vanier, M., … Gross, I. (2017). The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Letters, 386, 57–64. https://doi.org/10.1016/j.canlet.2016.10.040
Reimund, J.-M., & Freund, J.-N. (2017). Inflammatory Bowel Disease-associated Cancer. In M. Schwab (Ed.), Encyclopedia of Cancer (pp. 2256–2263). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_3046
Gillard, L., Billiauws, L., Stan-Iuga, B., Ribeiro-Parenti, L., Jarry, A.-C., Cavin, J.-B., … Le Beyec, J. (2016). Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome. Scientific Reports, 6, 28345. https://doi.org/10.1038/srep28345
Soret, C., Martin, E., Duluc, I., Dantzer, F., Vanier, M., Gross, I., … Domon-Dell, C. (2016). Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Letters, 374(2), 208–215. https://doi.org/10.1016/j.canlet.2016.02.026
Freund, J.-N., Duluc, I., Reimund, J.-M., Gross, I., & Domon-Dell, C. (2015). Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World Journal of Gastroenterology, 21(5), 1436–1443. https://doi.org/10.3748/wjg.v21.i5.1436
Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.-N., Duluc, I., … Léon, C. (2015). Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage. Journal of Thrombosis and Haemostasis: JTH, 13(1), 115–125. https://doi.org/10.1111/jth.12784
Rabineau, M., Flick, F., Mathieu, E., Tu, A., Senger, B., Voegel, J.-C., … Vautier, D. (2015). Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. Biomaterials, 37, 144–155. https://doi.org/10.1016/j.biomaterials.2014.10.023
Modica, S., Cariello, M., Morgano, A., Gross, I., Vegliante, M. C., Murzilli, S., … Moschetta, A. (2014). Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). The Journal of Biological Chemistry, 289(41), 28421–28432. https://doi.org/10.1074/jbc.M114.571513
Martianov, I., Cler, E., Duluc, I., Vicaire, S., Philipps, M., Freund, J.-N., & Davidson, I. (2014). TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PloS One, 9(2), e87365. https://doi.org/10.1371/journal.pone.0087365
Tréton, X., Pedruzzi, E., Guichard, C., Ladeiro, Y., Sedghi, S., Vallée, M., … Ogier-Denis, E. (2014). Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PloS One, 9(7), e101669. https://doi.org/10.1371/journal.pone.0101669
Bellis, J., Duluc, I., Freund, J.-N., & De Mey, J. R. (2013). Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum. Bio-Protocol, 3(20), e942. Retrieved from www.bio-protocol.org/e942
Derbal-Wolfrom, L., Pencreach, E., Saandi, T., Aprahamian, M., Martin, E., Greferath, R., … Freund, J.-N. (2013). Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. Oncogene, 32(36), 4313–4318. https://doi.org/10.1038/onc.2012.445
Saandi, T., Baraille, F., Derbal-Wolfrom, L., Cattin, A.-L., Benahmed, F., Martin, E., … Duluc, I. (2013). Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene, 32(32), 3782–3788. https://doi.org/10.1038/onc.2012.401
Chery, C., Hehn, A., Mrabet, N., Oussalah, A., Jeannesson, E., Besseau, C., … Guéant, J.-L. (2013). Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. Biochimie, 95(5), 995–1001. https://doi.org/10.1016/j.biochi.2013.01.022
Guéant, J.-L., Caillerez-Fofou, M., Battaglia-Hsu, S., Alberto, J.-M., Freund, J.-N., Duluc, I., … Daval, J.-L. (2013). Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie, 95(5), 1033–1040. https://doi.org/10.1016/j.biochi.2013.01.020
De Mey, J. R., & Freund, J.-N. (2013). Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers, 1(2), e24965. https://doi.org/10.4161/tisb.24965
Pereira, B., Sousa, S., Barros, R., Carreto, L., Oliveira, P., Oliveira, C., … Almeida, R. (2013). CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Research, 41(7), 3986–3999. https://doi.org/10.1093/nar/gkt087
Badique, F., Stamov, D. R., Davidson, P. M., Veuillet, M., Reiter, G., Freund, J.-N., … Anselme, K. (2013). Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization. Biomaterials, 34(12), 2991–3001. https://doi.org/10.1016/j.biomaterials.2013.01.018
Rabineau, M., Kocgozlu, L., Dujardin, D., Senger, B., Haikel, Y., Voegel, J.-C., … Vautier, D. (2013). Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division. PloS One, 8(10), e78468. https://doi.org/10.1371/journal.pone.0078468
Freund, J.-N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Annales De Pathologie, 32(5 Suppl), S24-27. https://doi.org/10.1016/j.annpat.2012.08.005
Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in Molecular Medicine, 18(9), 555–563. https://doi.org/10.1016/j.molmed.2012.07.006
Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A., & Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. Journal of Biological Regulators and Homeostatic Agents, 26(3), 515–526.
Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., … De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341. https://doi.org/10.1083/jcb.201204086
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3. https://doi.org/10.1053/j.gastro.2011.12.037
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., … Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469. https://doi.org/10.1093/nar/gkr1242
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., … Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474. https://doi.org/10.1242/dev.070722
Kocgozlu, L., Rabineau, M., Koenig, G., Haikel, Y., Schaaf, P., Freund, J.-N., … Vautier, D. (2012). The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity. Biomaterials, 33(3), 798–809. https://doi.org/10.1016/j.biomaterials.2011.10.024
Reimund, J.-M., Tavernier, M., Viennot, S., Hussein, I. A. H., Dupont, B., Justum, A.-M., … Lechevrel, M. (2012). Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives. https://doi.org/10.5772/25577
van de Ven, C., Bialecka, M., Neijts, R., Young, T., Rowland, J. E., Stringer, E. J., … Deschamps, J. (2011). Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development (Cambridge, England), 138(16), 3451–3462. https://doi.org/10.1242/dev.066118
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298. https://doi.org/10.1136/gut.2010.222323
Laurent, C., Svrcek, M., Flejou, J.-F., Chenard, M.-P., Duclos, B., Freund, J.-N., & Reimund, J.-M. (2011). Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. Inflammatory Bowel Diseases, 17(1), 232–240. https://doi.org/10.1002/ibd.21451
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., … Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., … Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727. https://doi.org/10.1542/peds.2009-3512
Coant, N., Ben Mkaddem, S., Pedruzzi, E., Guichard, C., Tréton, X., Ducroc, R., … Ogier-Denis, E. (2010). NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Molecular and Cellular Biology, 30(11), 2636–2650. https://doi.org/10.1128/MCB.01194-09
Barros, R., Camilo, V., Pereira, B., Freund, J.-N., David, L., & Almeida, R. (2010). Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochemical Society Transactions, 38(2), 358–363. https://doi.org/10.1042/BST0380358
Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., … Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell, 17(4), 516–526. https://doi.org/10.1016/j.devcel.2009.08.010
Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M.-T., Valanzano, R., … Moschetta, A. (2009). Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut, 58(9), 1250–1259. https://doi.org/10.1136/gut.2008.158386
Pons, L., Battaglia-Hsu, S.-F., Orozco-Barrios, C. E., Ortiou, S., Chery, C., Alberto, J.-M., … Gueant, J.-L. (2009). Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. PloS One, 4(7), e6325. https://doi.org/10.1371/journal.pone.0006325
Salehi, S., Eckley, L., Sawyer, G. J., Zhang, X., Dong, X., Freund, J.-N., & Fabre, J. W. (2009). Intestinal lactase as an autologous beta-galactosidase reporter gene for in vivo gene expression studies. Human Gene Therapy, 20(1), 21–30. https://doi.org/10.1089/hum.2008.101
Benahmed, F., Gross, I., Gaunt, S. J., Beck, F., Jehan, F., Domon-Dell, C., … Duluc, I. (2008). Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology, 135(4), 1238–1247, 1247.e1-3. https://doi.org/10.1053/j.gastro.2008.06.045
Barros, R., Pereira, B., Duluc, I., Azevedo, M., Mendes, N., Camilo, V., … Almeida, R. (2008). Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. The Journal of Pathology, 215(4), 411–420. https://doi.org/10.1002/path.2369
Bonhomme, C., Calon, A., Martin, E., Robine, S., Neuville, A., Kedinger, M., … Freund, J.-N. (2008). Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene, 27(32), 4497–4502. https://doi.org/10.1038/onc.2008.78