Jean-Noël FREUND

Directeur d’unité ; Responsable Equipe 1

Lien ORCID – CV Science – ResearcherID – ResearchGate

(+33) 03 88 27 53 52




Liste des publications :


Julien, E., Biasch, K., El Omar, R., Freund, J.-N., Gachet, C., Lanza, F., & Tavian, M. (2021). Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells. Stem Cells (Dayton, Ohio), 39(5), 636–649.
El Omar, R., Julien, E., Biasch, K., Guffroy, B., Lioure, B., Vallat, L., Gross, I., Domon-Dell, C., Lanza, F., Gachet, C., Negroni, M., Freund, J.-N., & Tavian, M. (2021). CDX2 regulates ACE expression in blood development and leukemia cells. Blood Advances, 5(7), 2012–2016.
Frau, C., Jamard, C., Delpouve, G., Guardia, G. D. A., Machon, C., Pilati, C., Neve, C. L., Laurent-Puig, P., Guitton, J., Galante, P. A. F., Penalva, L. O., Freund, J.-N., Fouchardière, C. de la, & Plateroti, M. (2021). Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy. Cancer Research.
Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Nevé, C. L., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway. Development.
Beck, M., Baranger, M., Moufok-Sadoun, A., Bersuder, E., Hinkel, I., Mellitzer, G., Martin, E., Marisa, L., Duluc, I., de Reynies, A., Gaiddon, C., Freund, J.-N., & Gross, I. (2020). The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Oncogene.
Tusamda Wakhloo, N., Anders, S., Badique, F., Eichhorn, M., Brigaud, I., Petithory, T., Vassaux, M., Milan, J.-L., Freund, J.-N., Rühe, J., Davidson, P. M., Pieuchot, L., & Anselme, K. (2020). Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography. Biomaterials, 234, 119746.
Licona, C., Delhorme, J.-B., Riegel, G., Vidimar, V., Cerón-Camacho, R., Boff, B., Venkatasamy, A., Tomasetto, C., da Silva Figueiredo Celestino Gomes, P., Rognan, D., Freund, J.-N., Le Lagadec, R., Pfeffer, M., Gross, I., Mellitzer, G., & Gaiddon, C. (2020). Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms. Inorganic Chemistry Frontiers, 7(3), 678–688.
Grall, E., Gourain, V., Naïr, A., Martin, E., Birling, M.-C., Freund, J.-N., & Duluc, I. (2019). Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs. Cell Death & Disease, 10(11), 812.
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155.
Rabineau, M., Flick, F., Ehlinger, C., Mathieu, E., Duluc, I., Jung, M., Senger, B., Kocgozlu, L., Schaaf, P., Lavalle, P., Freund, J.-N., Haikel, Y., & Vautier, D. (2018). Chromatin de-condensation by switching substrate elasticity. Scientific Reports, 8(1), 12655.
Balbinot, C., Armant, O., Elarouci, N., Marisa, L., Martin, E., De Clara, E., Onea, A., Deschamps, J., Beck, F., Freund, J.-N., & Duluc, I. (2018). The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. The Journal of Experimental Medicine, 215(3), 911–926.
Balbinot, C., Vanier, M., Armant, O., Nair, A., Penichon, J., Soret, C., Martin, E., Saandi, T., Reimund, J.-M., Deschamps, J., Beck, F., Domon-Dell, C., Gross, I., Duluc, I., & Freund, J.-N. (2017). Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death and Differentiation, 24(12), 2173–2186.
Dillenseger, J.-P., Goetz, C., Sayeh, A., Healy, C., Duluc, I., Freund, J.-N., Constantinesco, A., Aubertin-Kirch, G., & Choquet, P. (2017). Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. Journal of Medical Imaging (Bellingham, Wash.), 4(3), 035503.
Romain, B., Benbrika-Nehmar, R., Marisa, L., Legrain, M., Lobstein, V., Oravecz, A., Poidevin, L., Bour, C., Freund, J.-N., Duluc, I., Guenot, D., & Pencreach, E. (2017). Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Oncotarget, 8(24), 38351–38366.
Platet, N., Hinkel, I., Richert, L., Murdamoothoo, D., Moufok-Sadoun, A., Vanier, M., Lavalle, P., Gaiddon, C., Vautier, D., Freund, J.-N., & Gross, I. (2017). The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Letters, 386, 57–64.
Reimund, J.-M., & Freund, J.-N. (2017). Inflammatory Bowel Disease-associated Cancer. In M. Schwab (Ed.), Encyclopedia of Cancer (pp. 2256–2263). Springer Berlin Heidelberg.
Gillard, L., Billiauws, L., Stan-Iuga, B., Ribeiro-Parenti, L., Jarry, A.-C., Cavin, J.-B., Cluzeaud, F., Mayeur, C., Thomas, M., Freund, J.-N., Lacorte, J.-M., Le Gall, M., Bado, A., Joly, F., & Le Beyec, J. (2016). Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome. Scientific Reports, 6, 28345.
Soret, C., Martin, E., Duluc, I., Dantzer, F., Vanier, M., Gross, I., Freund, J.-N., & Domon-Dell, C. (2016). Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Letters, 374(2), 208–215.
Freund, J.-N., Duluc, I., Reimund, J.-M., Gross, I., & Domon-Dell, C. (2015). Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World Journal of Gastroenterology, 21(5), 1436–1443.
Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.-N., Duluc, I., Gachet, C., Lanza, F., & Léon, C. (2015). Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage. Journal of Thrombosis and Haemostasis: JTH, 13(1), 115–125.
Rabineau, M., Flick, F., Mathieu, E., Tu, A., Senger, B., Voegel, J.-C., Lavalle, P., Schaaf, P., Freund, J.-N., Haikel, Y., & Vautier, D. (2015). Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. Biomaterials, 37, 144–155.
Modica, S., Cariello, M., Morgano, A., Gross, I., Vegliante, M. C., Murzilli, S., Salvatore, L., Freund, J.-N., Sabbà, C., & Moschetta, A. (2014). Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). The Journal of Biological Chemistry, 289(41), 28421–28432.
Martianov, I., Cler, E., Duluc, I., Vicaire, S., Philipps, M., Freund, J.-N., & Davidson, I. (2014). TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PloS One, 9(2), e87365.
Tréton, X., Pedruzzi, E., Guichard, C., Ladeiro, Y., Sedghi, S., Vallée, M., Fernandez, N., Bruyère, E., Woerther, P.-L., Ducroc, R., Montcuquet, N., Freund, J.-N., Van Seuningen, I., Barreau, F., Marah, A., Hugot, J.-P., Cazals-Hatem, D., Bouhnik, Y., Daniel, F., & Ogier-Denis, E. (2014). Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PloS One, 9(7), e101669.
Bellis, J., Duluc, I., Freund, J.-N., & De Mey, J. R. (2013). Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum. Bio-Protocol, 3(20), e942.
Derbal-Wolfrom, L., Pencreach, E., Saandi, T., Aprahamian, M., Martin, E., Greferath, R., Tufa, E., Choquet, P., Lehn, J.-M., Nicolau, C., Duluc, I., & Freund, J.-N. (2013). Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. Oncogene, 32(36), 4313–4318.
Saandi, T., Baraille, F., Derbal-Wolfrom, L., Cattin, A.-L., Benahmed, F., Martin, E., Cardot, P., Duclos, B., Ribeiro, A., Freund, J.-N., & Duluc, I. (2013). Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene, 32(32), 3782–3788.
Chery, C., Hehn, A., Mrabet, N., Oussalah, A., Jeannesson, E., Besseau, C., Alberto, J.-M., Gross, I., Josse, T., Gérard, P., Guéant-Rodriguez, R. M., Freund, J.-N., Devignes, J., Bourgaud, F., Peyrin-Biroulet, L., Feillet, F., & Guéant, J.-L. (2013). Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. Biochimie, 95(5), 995–1001.
Guéant, J.-L., Caillerez-Fofou, M., Battaglia-Hsu, S., Alberto, J.-M., Freund, J.-N., Duluc, I., Adjalla, C., Maury, F., Merle, C., Nicolas, J.-P., Namour, F., & Daval, J.-L. (2013). Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie, 95(5), 1033–1040.
De Mey, J. R., & Freund, J.-N. (2013). Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers, 1(2), e24965.
Pereira, B., Sousa, S., Barros, R., Carreto, L., Oliveira, P., Oliveira, C., Chartier, N. T., Plateroti, M., Rouault, J.-P., Freund, J.-N., Billaud, M., & Almeida, R. (2013). CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Research, 41(7), 3986–3999.
Badique, F., Stamov, D. R., Davidson, P. M., Veuillet, M., Reiter, G., Freund, J.-N., Franz, C. M., & Anselme, K. (2013). Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization. Biomaterials, 34(12), 2991–3001.
Rabineau, M., Kocgozlu, L., Dujardin, D., Senger, B., Haikel, Y., Voegel, J.-C., Freund, J.-N., Schaaf, P., Lavalle, P., & Vautier, D. (2013). Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division. PloS One, 8(10), e78468.
Freund, J.-N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Annales De Pathologie, 32(5 Suppl), S24-27.
Barros, R., Freund, J.-N., David, L., & Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in Molecular Medicine, 18(9), 555–563.
Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A., & Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. Journal of Biological Regulators and Homeostatic Agents, 26(3), 515–526.
Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R. G., Freund, J.-N., & De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. The Journal of Cell Biology, 198(3), 331–341.
Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J.-N., & Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology, 142(4), 875-885.e3.
Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., Duluc, I., Gross, I., Freund, J.-N., & Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Research, 40(8), 3456–3469.
Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J.-N., Deschamps, J., & Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England), 139(3), 465–474.
Kocgozlu, L., Rabineau, M., Koenig, G., Haikel, Y., Schaaf, P., Freund, J.-N., Voegel, J.-C., Lavalle, P., & Vautier, D. (2012). The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity. Biomaterials, 33(3), 798–809.
Reimund, J.-M., Tavernier, M., Viennot, S., Hussein, I. A. H., Dupont, B., Justum, A.-M., Jurjus, A. R., Freund, J.-N., & Lechevrel, M. (2012). Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives.
van de Ven, C., Bialecka, M., Neijts, R., Young, T., Rowland, J. E., Stringer, E. J., Van Rooijen, C., Meijlink, F., Nóvoa, A., Freund, J.-N., Mallo, M., Beck, F., & Deschamps, J. (2011). Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development (Cambridge, England), 138(16), 3451–3462.
Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J.-N., David, L., & Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut, 60(3), 290–298.
Laurent, C., Svrcek, M., Flejou, J.-F., Chenard, M.-P., Duclos, B., Freund, J.-N., & Reimund, J.-M. (2011). Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. Inflammatory Bowel Diseases, 17(1), 232–240.
Entz-Werlé, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J.-M., Simo-Noumbissie, P., Guérin, E., Gaub, M.-P., Freund, J.-N., Boehm, N., Constantinesco, A., Lutz, P., Guenot, D., & Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Translational Oncology, 3(6), 344–353.
Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., Gross, I., Rowland, J., Kim, S., & Freund, J.-N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics, 126(3), e723-727.
Coant, N., Ben Mkaddem, S., Pedruzzi, E., Guichard, C., Tréton, X., Ducroc, R., Freund, J.-N., Cazals-Hatem, D., Bouhnik, Y., Woerther, P.-L., Skurnik, D., Grodet, A., Fay, M., Biard, D., Lesuffleur, T., Deffert, C., Moreau, R., Groyer, A., Krause, K.-H., … Ogier-Denis, E. (2010). NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Molecular and Cellular Biology, 30(11), 2636–2650.